Coronavirus disease 2019 (COVID-19) is a highly infectious viral disease caused by the novel SARS-CoV-2 virus. Different prediction techniques have been developed to predict the coronavirus disease’s existence in patients. However, the accurate prediction was not improved and time consumption was not minimized. In order to address these existing problems, a novel technique called Biserial Targeted Feature Projection-based Radial Kernel Regressive Deep Belief Neural Learning (BTFP-RKRDBNL) is introduced to perform accurate disease prediction with lesser time consumption. The BTFP-RKRDBNL techniques perform disease prediction with the help of different layers such as two visible layers namely input and layer and two hidden layers. Initially, the features and data are collected from the dataset and transmitted to the input layer. The Point Biserial Correlative Target feature projection is used to select relevant features and other irrelevant features are removed with minimizing the disease prediction time. Then the relevant features are sent to the hidden layer 2. Next, Radial Kernel Regression is applied to analyze the training features and testing disease features to identify the disease with higher accuracy and a lesser false positive rate. Experimental analysis is planned to measure the prediction accuracy, sensitivity, and specificity, and prediction time for different numbers of patients. The result illustrates that the method increases the prediction accuracy, sensitivity, and specificity by 10, 6, and 21% and reduces the prediction time by 10% as compared to state-of-the-art works.