2018
DOI: 10.1097/spc.0000000000000339
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Predicting mucositis risk associated with cytotoxic cancer treatment regimens: rationale, complexity, and challenges

Abstract: The identification of specific factors (both genomic and otherwise) which contribute to CRRMI risk represents an important opportunity to apply principles of precision medicine to the management of regimen-related toxicities.

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Cited by 22 publications
(12 citation statements)
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“…The ERK signaling pathway acts in conjunction with extra- and intracellular signaling events, while the inflammatory response pathway is likely linked to the activation of the innate immune response. It is interesting to note how these pathways are shared with diseases with similar clinical presentation (such as IBS), therefore lending strength to the hypothesis that risk for development of a certain clinical phenotype (i.e., diarrhea) is related to a patient specific and individual genomic profile [37].…”
Section: Risk Factorsmentioning
confidence: 99%
“…The ERK signaling pathway acts in conjunction with extra- and intracellular signaling events, while the inflammatory response pathway is likely linked to the activation of the innate immune response. It is interesting to note how these pathways are shared with diseases with similar clinical presentation (such as IBS), therefore lending strength to the hypothesis that risk for development of a certain clinical phenotype (i.e., diarrhea) is related to a patient specific and individual genomic profile [37].…”
Section: Risk Factorsmentioning
confidence: 99%
“…Identification of important targetable biomarkers related to the pathogenesis of chemotherapy-induced mucositis would be of great importance. Such biomarkers could potentially serve as a basis for improved clinical management of cancer patients in the future 10 , 11 .…”
Section: Introductionmentioning
confidence: 99%
“…Loss of intestinal epithelial barrier function is an aggravating factor for mucositis patients, as it may lead to increased epithelial permeability, and thus to translocation of intestinal bacteria to the systemic circulation [29]. Therefore, stimulation of expression of epithelial wall factors is another way in which dairy origin probiotics interact with the host cells, providing defensive mechanisms against harmful invasive bacteria, which can worsen the prognostic of mucositis.…”
Section: Mechanism Of Interaction Between Dairy Origin Probiotics Andmentioning
confidence: 99%
“…Moreover, L. rhamnosus GG supernatant limits 5-FU induced apoptosis in IEC-6 rat intestinal epithelial cells, by reducing the expression of caspase 3 and 7 [37]. As the epithelial barrier is disrupted by the primary effects of mucositis, such as apoptosis, some studies suggest that translocated bacterial products could serve as sensitizing antigens to create secondary adaptive immune responses against the commensal microbiota colonizing the mucosa [29]. In this context, some dairy origin lactobacilli have also been described to stimulate the production of anti-inflammatory cytokines, like IL-10, involved in immunological tolerance to intestinal microbes antigens [12,25].…”
Section: Mechanism Of Interaction Between Dairy Origin Probiotics Andmentioning
confidence: 99%