Predicting neuroleptic response from a combination of multilevel variables in acute schizophrenic patients

Bartkó, György; Frecska, Ede; Horvath, Szabolcs; Zádor, György; Arató, M.

doi:10.1111/j.1600-0447.1990.tb03070.x

Cited by 38 publications

(7 citation statements)

References 27 publications

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“…The decrease in mean SANS ratings at 12 months was 20.6%. These results agree with previous reports that patients with more severe psychopathology respond better to treatment (MSller et al, 1985;Bartk6 et al, 1990).…”

Section: Psychopathologysupporting

confidence: 93%

Multiple-outcome criteria in schizophrenia: an overview of outcome with clozapine

1995

Eur. psychiatr.

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The outcome of treatment in schizophrenia is best considered as a multidimensional construct. This report lists thirteen categories of outcome measures that have been studied in schizophrenia research, among the most important of which are psychopathology, cognitive function, interpersonal social function, quality of life, extrapyramidal function, the suicide tendeccy and the need for hospitalisation. Clozapine is effective in achieving improved outcome in all these measures in a high percentage of neuroleptic-resistant patients. Ninety-two of 180 (51.1%) clozapine-treated neuroleptic-resistant patients achieved a decrease of 20% in Brief Psychiatric Rating Scale total scores at six weeks using the 0-6 scaling system. Cognitive function contributes importantly to overall function for schizophrenia. Clozapine has been shown to improve some types of cognition in schizophrenia, especially semantic memory and some tests of executive function. Clozapine has also been shown to decrease the incidence of suicide and hospitalisation. The task of deciding which therapies to use in schizophrenia should encompass the spectrum of benefits of each therapy, their risks and costs, in relation to all alternatives.

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Section: Psychopathologysupporting

confidence: 93%

Multiple-outcome criteria in schizophrenia: an overview of outcome with clozapine

1995

Eur. psychiatr.

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“…The significance of this is not clear, but it does not imply that clozapine is an ineffective treatment for less psychotic and less treatment-refractory patients. More severe positive symptoms at baseline have also been correlated with a more favorable outcome to treatment with typical antipsychotics in acute psychosis (Bartko, Frecska, Horvath, Zador, & Arato, 1990). Other studies show that less severely ill patients may also respond better to clozapine than to typical antipsychotics (Claghorn et al, 1987; Pickar et al, 1994).…”

Section: Schizophreniamentioning

confidence: 99%

The expanding indications for clozapine.

Young¹,

Longhurst²,

Bowers³

et al. 1997

Experimental and Clinical Psychopharmacology

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Clozapine is increasingly being used for clinical indications in addition to treatment-resistant schizophrenia; this article reviews the relevant literature. The first section reassesses the risks associated with clozapine treatment, particularly agranulocytosis. The next section discusses its use for schizophrenia in patients who are treatment resistant, not treatment resistant, and intolerant of traditional drug treatments. Subsequent sections address its use in mood disorders, neurologic conditions, comorbid substance abuse, aggressive behavior, and childhood schizophrenia. Each includes the initial rationale for the use of clozapine in the disorder, a critical evaluation of the relevant literature, and theories as to why clozapine's unique pharmacodynamic profile may be efficacious for the specific condition. This body of literature suggests clozapine may be an effective treatment for a wide range of disorders.

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“…Treatment response to APD therapy has also been shown to be associated with baseline symptom severity (Bartkó et al, 1990; McEvoy et al, 1991; Cuesta et al, 1994; Crespo-Facorro et al, 2007), duration of psychotic illness (McEvoy et al, 1991; Keck et al, 1995), age (Keck et al, 1995), and gender (Ghafari et al, 2013; Seeman, 1997). Interestingly, lower severity of general psychopathology before exposure to medication is associated with poorer treatment response (Crespo-Facorro et al, 2007), a finding that is likely related to a floor effect.…”

Section: Introductionmentioning

confidence: 99%

Basal ganglia volume in unmedicated patients with schizophrenia is associated with treatment response to antipsychotic medication

Hutcheson

Clark

Bolding

et al. 2014

Psychiatry Research: Neuroimaging

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We investigated the relationship between basal ganglia volume and treatment response to the atypical antipsychotic medication risperidone in unmedicated patients with schizophrenia. Basal ganglia volumes included the bilateral caudate, putamen, and pallidum and were measured using the Freesurfer automated segmentation pipeline in 23 subjects. Also, baseline symptom severity, duration of illness, age, gender, time off medication, and exposure to previous antipsychotic were measured. Treatment response was significantly correlated with all three regions of the bilateral basal ganglia (caudate, putamen, and pallidum), baseline symptom severity, duration of illness, and age but not gender, time off antipsychotic medication, or exposure to previous antipsychotic medication. The caudate volume was the basal ganglia region that demonstrated the strongest correlation with treatment response and was significantly negatively correlated with patient age. Caudate volume was not significantly correlated with any other measure. We demonstrated a novel finding that the caudate volume explains a significant amount of the variance in treatment response over the course of six-weeks of risperidone pharmacotherapy even when controlling for baseline symptom severity and duration of illness.

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Predicting neuroleptic response from a combination of multilevel variables in acute schizophrenic patients

Cited by 38 publications

References 27 publications

Multiple-outcome criteria in schizophrenia: an overview of outcome with clozapine

Multiple-outcome criteria in schizophrenia: an overview of outcome with clozapine

The expanding indications for clozapine.

Basal ganglia volume in unmedicated patients with schizophrenia is associated with treatment response to antipsychotic medication

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