Predicting Nodal Status Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Patients With Locally Advanced Breast Cancer Undergoing Neoadjuvant Chemotherapy With and Without Sequential Trastuzumab

Hsiang, David; Yamamoto, Maki; Mehta, Rita S.; Su, Min‐Ying; Baick, Choong; Lane, Karen; Butler, John

doi:10.1001/archsurg.142.9.855

Cited by 30 publications

(14 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings contribute to a range of recently elucidated quantitative markers that together define imaging phenotypes that have shown promise in the identification of additional cancer subtypes, lesion invasiveness, grade, and lymph node status, with associated treatment and prognostic implications. [5][6][7][8][9][10][11][18][19][20] Classification of breast cancer by molecular subtype furthermore has clinical value, as current treatment guidelines are determined by tumor subtype. 16 HER2 expression by cancers in particular needs to be determined, as anti-HER2 therapy has well documented efficacy.…”

Section: Discussionmentioning

confidence: 99%

MRI phenotype of breast cancer: Kinetic assessment for molecular subtypes

Blaschke

Abé

2015

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

MRI phenotype of breast cancer: Kinetic assessment for molecular subtypes

Blaschke

Abé

2015

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…DCE-MRI has the potential to be a powerful tool for predicting therapeutic responsiveness (Sorensen, 2006) because it is in common use and is readily available (Chen et al , 2006; Ah-See et al , 2008). In previous clinical studies DCE-MRI measurements have been shown to correlate with change in tumour volume (Martincich et al , 2004; Hsiang et al , 2007) and with responsiveness to neoadjuvant chemotherapy (Padhani et al , 2006; Loo et al , 2008). Specifically, the transvascular transport parameter ( K trans ) has been shown to correlate with therapeutic responsiveness (Hayes et al , 2002; Ah-See et al , 2008).…”

mentioning

confidence: 91%

Mechanistic modelling of dynamic MRI data predicts that tumour heterogeneity decreases therapeutic response

et al. 2010

View full text Add to dashboard Cite

Background:Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) contains crucial information about tumour heterogeneity and the transport limitations that reduce drug efficacy. Mathematical modelling of drug delivery and cellular responsiveness based on underutilised DCE-MRI data has the unique potential to predict therapeutic responsiveness for individual patients.Methods:To interpret DCE-MRI data, we created a modelling framework that operates over multiple time and length scales and incorporates intracellular metabolism, nutrient and drug diffusion, trans-vascular permeability, and angiogenesis. The computational methodology was used to analyse DCE-MR images collected from eight breast cancer patients at Baystate Medical Center in Springfield, MA.Results:Computer simulations showed that trans-vascular transport was correlated with tumour aggressiveness because increased vessel growth and permeability provided more nutrients for cell proliferation. Model simulations also indicate that vessel density minimally affects tissue growth and drug response, and nutrient availability promotes growth. Finally, the simulations indicate that increased transport heterogeneity is coupled with increased tumour growth and poor drug response.Conclusion:Mathematical modelling based on DCE-MRI has the potential to aid treatment decisions and improve overall cancer care. This model is the critical first step in the creation of a comprehensive and predictive computational method.

show abstract

“…Sagittal images or 3D MR images may be useful in detecting the intraMRI; however, unfortunately we did not use the technique at that time. Dynamic contrast-enhanced MRI has recently been shown to be helpful in determining tumor and axillary nodal status [11]; however, the usefulness of MRI to detect intraMLN has not been described. Jansen et al [12] reported that, with the use of SLN biopsy, intraMLNs may be detected more frequently on scintigraphy.…”

Section: Discussionmentioning

confidence: 99%

Isolated retromammary lymph node metastasis of breast cancer without axillary lymph node involvement: a case report with a false-negative sentinel lymph node biopsy

et al. 2009

View full text Add to dashboard Cite

A 54-year-old woman visited our hospital with a palpable tumor in her left breast, which was diagnosed as invasive ductal carcinoma. Breast-conserving surgery was performed, in association with a sentinel lymph node (SLN) biopsy and back-up dissection of the axillary lymph nodes. One dyed axillary lymph node with high radioactivity was defined as an SLN, and intraoperative frozen-section analysis of the SLN was negative for metastasis. The final pathological diagnosis of the tumor was invasive ductal carcinoma, and one small lymph node, located in the retromammary space, just under the tumor, was positive for metastasis. The backup axillary lymph nodes were not metastatic. This patient was diagnosed false-negative by SLN biopsy, despite being positive for retroMLN metastasis. It should be recognized that retroMLNs are difficult to detect preoperatively, or intra-operatively, using dye or radiocolloid, if they are located in the post-tumoral retro-mammary space. RetroMLNs may be a pitfall in SLN biopsies.

show abstract

Predicting Nodal Status Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Patients With Locally Advanced Breast Cancer Undergoing Neoadjuvant Chemotherapy With and Without Sequential Trastuzumab

Cited by 30 publications

References 25 publications

MRI phenotype of breast cancer: Kinetic assessment for molecular subtypes

MRI phenotype of breast cancer: Kinetic assessment for molecular subtypes

Mechanistic modelling of dynamic MRI data predicts that tumour heterogeneity decreases therapeutic response

Isolated retromammary lymph node metastasis of breast cancer without axillary lymph node involvement: a case report with a false-negative sentinel lymph node biopsy

Contact Info

Product

Resources

About