Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

Vermeulen, Joëlle; Preter, Katleen De; Naranjo, Arlene; Vercruysse, Liesbeth; Roy, Nadine Van; Hellemans, Jan; Swerts, Katrien; Bravo, S Araneda; Scaruffi, Paola; Tonini, Gian Paolo; Bernardi, Bruno; Noguera, Rosa; Piqueras, Marta; Cañete, Adela; Castel, Victoria; Janoueix‐Lerosey, Isabelle; Delattre, Olivier; Schleiermacher, Gudrun; Michon, Jean; Combaret, Valreie; Fischer, Matthias; Oberthuer, André; Ambros, Peter F.; Beiske, Klaus; Bénard, Jean; Marques, Bárbara; Rubie, H; Kohler, Janice A.; Pötschger, Ulrike; Ladenstein, Ruth; Hogarty, Michael D.; McGrady, Patrick; London, Wendy B.; Laureys, Geneviève; Speleman, Franki; Vandesompele, Jo

doi:10.1016/s1470-2045(09)70154-8

Cited by 172 publications

(175 citation statements)

References 29 publications

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“…According to Vermeulen`s survey a new and successful system for outcome prediction of NB in children was developed, in which a set of 59 genes is evaluated by PCR technique (Vermeulen et al, 2009). In Bernstein`s study of Canadian patients the overall 10-year survival rate for the 295 cases of neuroblastoma was 55% which is comparable with our finding illustrates the overall survival of 46.7±6%.…”

Section: Discussionsupporting

confidence: 81%

Neuroblastoma in Iran: An Experience of 32 Years at a Referral Childrens Hospital

Bahoush

Arab²,

Rafsanjani³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: This survey aim was to evaluate the epidemiology and outcomes of neuroblastoma patients in one the most important children referral hospitals in Iran as a model from developing countries. Materials and Methods: This retrospective, non-randomized analytic study was conducted on 219 newly diagnosed neuroblastoma cases. Results: The age of patients ranged from 1-156 months with the average of 40.5±2.44, with a male/female ratio of 1.9/1. Of the total, 172 (78.5%) were children and 47 (21.5%) were infants The adrenals were the most common primary site (60%). Stage 4 at diagnosis accounted for about 54% of all enrolled patients. Infants had significantly better cumulative survival (85±8%) than children (33±7%) during the follow up period and the survival rate improved from 33±7% in 1974-1994 to 58±9% in 1995-2005. Conclusions: This study indicates that our patient population with neuroblastomas tends to have more advanced disease, perhaps with poor biologic markers, but our analysis shows that the outcomes have improved over 32 years although the overall survival of Iranian neuroblastoma patients is still lower than developed countries. Late diagnosis, inability to determine risk group during the years of study and using single protocol for all enrolled patients can be the reasons of lower survival rate.

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Section: Discussionsupporting

confidence: 81%

Neuroblastoma in Iran: An Experience of 32 Years at a Referral Childrens Hospital

Bahoush

Arab²,

Rafsanjani³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…An additional cohort of 366 neuroblastoma tumours, originally described by Vermeulen et al (2009), were also included. All samples were obtained at diagnosis.…”

Section: Patient Samplesmentioning

confidence: 99%

“…Expression data were normalized using the mean expression value per sample (Mestdagh et al, 2009). For the independent validation cohort of 366 tumours, RT-qPCR data were normalized using qbasePLUS v1.2 as described previously (Vermeulen et al, 2009). T-UCR RT-qPCR data are available in rdml format (Lefever et al, 2009) …”

Section: Rt-qpcrmentioning

confidence: 99%

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

et al. 2010

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Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis

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“…[8][9][10][11][12][13] Abnormal gene expression profiles were also found associated with disease aggressiveness and tumor progression. [14][15][16][17][18][19] The foregoing indicates that tumor aggressiveness of metastatic NB depends on patients' age, genomic alterations and transcriptome deregulation. However, a clear evidence of the relationship between patients' age and tumor genomic features is still lacking.…”

mentioning

confidence: 99%

Age‐dependent accumulation of genomic aberrations and deregulation of cell cycle and telomerase genes in metastatic neuroblastoma

Coco

Theißen

Scaruffi

et al. 2012

Intl Journal of Cancer

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About 50% of children with neuroblastoma (NB) show a metastatic disease and have a poor prognosis. However, disease progression is greatly variable and depends on patients' age and MYCN oncogene amplification. To investigate the role of patients' age in tumor aggressiveness, we performed array-CGH and gene expression profiles of three groups (G) of metastatic NBs: G1, stage 4S patients and MYCN single copy (MYCN-) tumors; G2, stage 4 patients, ≤18 months of age, MYCN- tumors and favorable outcome and G3, Stage 4 patients, a19 months with unfavorable outcome. G1 was characterized by numerical aberrations prevalently; on the contrary, all G3 tumors had structural rearrangements, whereas G2 showed an intermediate pattern. The average of numerical alterations decreased significantly from G1 to G2 to G3 (p < 0.01). Contrarily, the number of structural aberrations increased from G1 to G2 to G3 (p< 2.35 E-05). Noteworthy, G3/MYCN- NBs were characterized by several complex intrachromosome rearrangements. Expression analysis of the three groups showed significant differences in genes of Rho and Ras signaling pathways, development and adhesion, cell cycle regulation and telomerase activity. Accumulation of structural alterations increased with patients' age and was associated with a more aggressive disease. Abnormal expression of genes involved in cell cycle and telomerase in G3 may be responsible for the genomic instability in this cohort of patients. The higher DNA instability observed in G3/MYCN- NBs than in MYCN-amplified G3 may also explain why patients a19 months have a poor outcome independently by MYCN status. Copyright © 2012 UICC

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Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

Cited by 172 publications

References 29 publications

Neuroblastoma in Iran: An Experience of 32 Years at a Referral Childrens Hospital

Neuroblastoma in Iran: An Experience of 32 Years at a Referral Childrens Hospital

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Age‐dependent accumulation of genomic aberrations and deregulation of cell cycle and telomerase genes in metastatic neuroblastoma

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