Predicting personalized multiple birth risks after in vitro fertilization–double embryo transfer

Lannon, B.M.; Choi, ByoungSeon; Hacker, Michele R.; Dodge, Laura E.; Malizia, B.A.; Barrett, C.B.; Wong, Wing Hung; Yao, Mylene; Penzias, Alan S.

doi:10.1016/j.fertnstert.2012.04.011

Cited by 20 publications

(23 citation statements)

References 29 publications

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“…Moreover, there is accumulating evidence that both pregnancy rates [1,27,[30][31][32] and obstetric and neonatal outcomes [11,19] may be improved in cryopreserved cycles, specifically due to uncoupling the processes of COH and embryo transfer. Thus, as routine cryopreservation may emerge as a method to optimize the safety and efficacy of assisted reproduction, the development of prediction models specific to eSET in cryopreserved cycles will become increasingly important, as recently published for fresh embryo transfers [14,36].…”

Section: Discussionmentioning

confidence: 99%

Predictors of twin live birth following cryopreserved double embryo transfer on day 3

Kaser

Missmer

Correia

et al. 2013

J Assist Reprod Genet

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Purpose To determine embryo and cycle-specific parameters associated with twin live birth in day 3 cryopreserved double embryo transfer (DET) cycles, and to propose a new prediction model for external validation. Methods All cycles with autologous or donor cryopreserved DET of day 3 embryos from 2002 to 2011 at a single academic institution with a singleton or twin live birth were included (n=207). Patient characteristics, post-thaw embryo morphology and freeze-thaw parameters were compared between patients with a single and twin live birth. Results Demographic characteristics were similar, except that patients delivering twins were younger at age of cryopreserved embryo transfer (CET), fewer were parous and more were anovulatory. Duration of embryo storage, time in culture post-thaw, endometrial thickness and use of assisted hatching were comparable. Six predictors of twin delivery were identified: patient age <35 year at CET, intact survival of the lead embryo, resumption of mitosis, 7-8 viable cells in the non-lead embryo, transfer of a lead embryo with ≥7 cells and a sum of ≥14 viable cells in the two transferred embryos. Regression modeling predicted a step-wise increase in the probability of twins with addition of each predictor; with all six present, the risk of twins was predicted to be 53 % and with none present, the risk decreased to 6 %. Conclusions The six identified variables associated with twin live birth following day 3 cryopreserved DET have been applied to derive a prediction model for estimating the risk of twin delivery. External validation of the model is required prior to clinical application.

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Section: Discussionmentioning

confidence: 99%

Predictors of twin live birth following cryopreserved double embryo transfer on day 3

Kaser

Missmer

Correia

et al. 2013

J Assist Reprod Genet

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show abstract

“…The performance of each model was tested as described elsewhere (2,5,17). Briefly, for each model, we computed the log-likelihood based on the combination of two separate sets of models.…”

Section: Discussionmentioning

confidence: 99%

“…The outcome of an IVF cycle was defined as ''live birth'' if [1] the fresh ET directly resulted in a live birth; or [2] the fresh ET did not result in a live birth, but the transfer of cryopreserved-thawed embryos that were produced by that fresh IVF cycle resulted in a live birth. Linking the outcomes of fresh and cryopreserved ETs this way provided information on the total reproductive potential of the embryos produced by a fresh cycle (2,5,17).…”

Section: Patients Ivf Treatments and Definition Of Live Birthmentioning

confidence: 99%

Antimüllerian hormone levels and antral follicle count as prognostic indicators in a personalized prediction model of live birth

Nelson

Fleming

Gaudoin

et al. 2015

Fertility and Sterility

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“…The “best viable” embryo selection and also the optimal implantation regulation, both are going to be solved by new diagnostics and treatment methods based on personalized omics profiling [3]. Molecules of embryo-endometrial cross talk that are engaged in regulation of the embryo implantation and selected components of follicular fluid as well as embryo media will play a role on a developmental potential of the embryo and treatment efficiency.…”

Section: Suggested Technologic Approachesmentioning

confidence: 99%

Personalized treatment of infertility – way to increase treatment efficiency

Králíčková

2014

EPMA Journal

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Predicting personalized multiple birth risks after in vitro fertilization–double embryo transfer

Cited by 20 publications

References 29 publications

Predictors of twin live birth following cryopreserved double embryo transfer on day 3

Predictors of twin live birth following cryopreserved double embryo transfer on day 3

Antimüllerian hormone levels and antral follicle count as prognostic indicators in a personalized prediction model of live birth

Personalized treatment of infertility – way to increase treatment efficiency

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