Predicting quality of life impairment in chronic schizophrenia from cognitive variables

Ritsner, Michael S.

doi:10.1007/s11136-007-9195-3

Cited by 60 publications

(47 citation statements)

References 36 publications

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“…The tests were performed one-tailed, and power calculations showed that the power for the t-test to detect a mean difference between controls and patients amounting to a medium effect size (Cohen's d 00.5) was b 00. 48 with an a error of 5% (one-tailed), and for a large effect size (Cohen's d 00.8) the power was b00.82. We also used bootstrap techniques to create 1000 Spearman's rank correlation samples to investigate the relation between TEA and BADS performance scores and symptom ratings (BPRS), medication (percent of maximum dose) and length of illness.…”

Section: Discussionmentioning

confidence: 99%

Attention and executive function in people with schizophrenia: Relationship with social skills and quality of life

Tyson

Laws

Flowers

et al. 2008

International Journal of Psychiatry in Clinical Practice

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Executive function and attention are highly complex cognitive constructs that typically reveal evidence of impairment in people with schizophrenia. Studies in this area have traditionally utilised abstract tests of cognitive function and the importance of using more ecologically valid tests has not been extensively recognised. In addition, there has been little previous examination of the relationship between these key cognitive abilities and social functioning and quality of life in this population. Thirty-six schizophrenic patients and 15 controls were assessed on the Behavioural Assessment of the Dysexecutive Syndrome (BADS) test, three subtests from the Test of Everyday Attention (TEA), a measure of social functioning and a quality of life measure. Analysis of subtest scores revealed that patients were impaired on all attentional measures, but only one BADS subtest score in addition to the BADS profile score. However, 23 patients demonstrated no impairment in their BADS profile scores whilst being impaired on at least one attentional measure. Only the BADS profile score predicted social functioning and quality of life in schizophrenic patients. We conclude that ecologically valid tests of attention and executive function can play an important role in defining the cognitive deficits in schizophrenia and how such deficits relate to social function and quality of life.

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Section: Discussionmentioning

confidence: 99%

Attention and executive function in people with schizophrenia: Relationship with social skills and quality of life

Tyson

Laws

Flowers

et al. 2008

International Journal of Psychiatry in Clinical Practice

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“…Some previous research groups have investigated the relation between QOL and cognitive function in people with schizophrenia, and reported the significant correlations between QOL and some domains of cognitive function such as verbal memory, vocabulary, fluency performance, attention, social knowledge, and executive function (12,28,(29)(30)(31)(32).…”

Section: Relation Between Cognitive Func-tion and Quality Of Lifementioning

confidence: 99%

Quality of life and its predictors in people with schizophrenia

Tomotake

2011

J. Med. Invest.

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“…Neurocognitive impairment has been found to limit creativity, work performance, quality of life, selfesteem, and psychosocial functioning substantially in patients with other severe mental illnesses, especially schizophrenia (16)(17)(18)(19)(20)(21). In BPD, there has been increasing recognition of more functional impairment than had been realized formerly, particularly with regard to independent living, personal relationships, and vocational success (22).…”

mentioning

confidence: 99%

“…However, in a recent review of 15 studies, Bauer and colleagues (26) found that, except for ongoing depressive symptoms, few of these factors were consistently associated with poor functional outcomes across studies. Neurocognitive functioning, remarkably, was not examined in most of the preceding studies of BPD patients, despite having been explored extensively in relation to functional disability in patients with schizophrenia and other neuropsychiatric conditions (17)(18)(19)(20)(21)27).…”

mentioning

confidence: 99%

Neurocognitive impairment in bipolar disorder patients: functional implications

2009

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Growing evidence suggests that bipolar disorder (BPD) patients experience prominent neurocognitive impairment not only during acute mood episodes (1-3) but also during euthymia (1,(4)(5)(6)(7)(8)(9)(10)(11)(12). A recent meta-analytic review of 39 studies comparing neurocognitive functioning in 948 euthymic BPD patients and 1,128 normal controls, matched for age, sex, education, and estimated premorbid IQ, found medium-to-large effect sizes (ES, as group differences ⁄ variance) for impaired attention and processing speed (ES = 0.60-0.79), episodic memory (ES = 0.43-0.81), and executive functioning (ES = 0.47-0.71) in the BPD patients (11). Another meta-analytic review of 20 studies, also comparing neurocognitive performance in euthymic BPD patients to matched normal controls, found deficits of similar magnitude in measures of executive functions, verbal learning, immediate Background: Functional recovery among treated bipolar disorder (BPD) patients is far less likely than syndromal and even symptomatic recovery. We hypothesized that increasingly well-documented aspects of cognitive impairment may contribute to poor functional outcomes in BPD patients, and reviewed the available research on the topic.Methods: Computerized literature searching identified 12 studies with 13 comparisons that simultaneously evaluated cognitive and functional status in euthymic (n = 8) or non-euthymic (n = 5 comparisons) adult BPD patients versus otherwise similar healthy controls.Results: In 6 ⁄ 8 studies of euthymic BPD patients and 5 ⁄ 5 studies of non-euthymic BPD patients, neurocognitive impairment was significantly associated with impaired psychosocial functioning, even after adjusting for residual mood symptoms and relevant demographic and clinical variables. Cognitive status was consistently assessed with standardized, performance-based neuropsychological tests, but functional status usually was based on subjective self-appraisals. Approximately 55% of BPD patients were unemployed.Conclusions: Available studies are limited by subjective assessments of functional status rather than objective, performance-based measures. Nevertheless, they support the hypothesis that enduring aspects of cognitive impairment found even in euthymic BPD patients are associated with inferior functioning. These findings encourage further studies with better assessment methods and greater rehabilitative efforts in BPD patients.

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Predicting quality of life impairment in chronic schizophrenia from cognitive variables

Cited by 60 publications

References 36 publications

Attention and executive function in people with schizophrenia: Relationship with social skills and quality of life

Attention and executive function in people with schizophrenia: Relationship with social skills and quality of life

Quality of life and its predictors in people with schizophrenia

Neurocognitive impairment in bipolar disorder patients: functional implications

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