2015
DOI: 10.1016/j.ebiom.2015.07.006
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Predicting Risk at the End of the End: Telomere G-tail as a Biomarker

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Cited by 5 publications
(9 citation statements)
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References 10 publications
(11 reference statements)
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“…For example, Wan et al reported the association of telomere length measured by using circulating serum DNA with the risk of hepatocellular carcinoma in hepatitis B virus patients [157]. Meanwhile, it has been also reported that length of the telomeric G-tail (3′-overhang) instead of telomere length, is a better biomarker for predictions of disease risk [158,159]. TERRA also might become a useful biomarker because it is included in exosomes as above mentioned.…”
Section: Conclusion and Future Perspectivesmentioning
confidence: 99%
“…For example, Wan et al reported the association of telomere length measured by using circulating serum DNA with the risk of hepatocellular carcinoma in hepatitis B virus patients [157]. Meanwhile, it has been also reported that length of the telomeric G-tail (3′-overhang) instead of telomere length, is a better biomarker for predictions of disease risk [158,159]. TERRA also might become a useful biomarker because it is included in exosomes as above mentioned.…”
Section: Conclusion and Future Perspectivesmentioning
confidence: 99%
“…Additional protein-protein interactions mediate the communication of telomeres with structural components of the cell nucleus (16). Because of its crucial role in chromosome protection, it has been recently suggested that shorter G-tail length is more directly associated with age and higher disease risk factors than total telomere length (TL) (17), suggesting G-tail as a new potential biomarker, alternative to TL per se (18). Besides shelterin, G-quadruplexes are other higher-order structures, protecting the 3' overhang of telomeres from being accessed by the enzyme telomerase (19).…”
Section: Telomere-binding Proteinsmentioning
confidence: 99%
“…Short telomeres are associated with increased risk of early death and measurement of TL has been mentioned as a possible biomarker of aging and many age-related diseases, also because of (i) its tight correlation with oxidative stress and cellular senescence, two important regulators of human aging (9), (ii) its relation to basic biological mechanisms, (iii) record of past cell divisions, (iv) its high correlation across tissues and (v) association with lifestyle factors (126). A lot of effort has been done to evaluate whether clinical practice could benefit from TL measurement; © 1996-2018 Recent discoveries showed that DNA can be damaged also with normal TL, if G-tail structure is disrupted, suggesting, that G-tail length contributes more to pathologies than TL itself (18). It has been associated with age and vascular risk factors (17) and methods for the examination of G-tail length with a high-throughput platform using genomic DNA or cell lysate are faster than classical methods for TL determination, giving G-tail priority as a biomarker choice in the future studies (127).…”
Section: Telomeres As a Biomarkermentioning
confidence: 99%
“…First brought to light in 1993, a simple answer to the phenomenon still eludes us [ 44 ]. Thus, evading common perception—the recurrent theme of telomere behaviour—the overhang might actually render the telomeres the ability to be capped and protected [ 45 , 46 ].…”
Section: Telomere-associated Protein Complexes and Other Accessorymentioning
confidence: 99%