Predicting SARS-CoV-2 infection among hemodialysis patients using multimodal data

Abstract

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has created more devastation among dialysis patients than among the general population. Patient-level prediction models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are crucial for the early identification of patients to prevent and mitigate outbreaks within dialysis clinics. As the COVID-19 pandemic evolves, it is unclear whether or not previously built prediction models are still sufficiently effective.MethodsWe developed a machine learning (XGBoost) model to predict during the incubation period a SARS-CoV-2 infection that is subsequently diagnosed after 3 or more days. We used data from multiple sources, including demographic, clinical, treatment, laboratory, and vaccination information from a national network of hemodialysis clinics, socioeconomic information from the Census Bureau, and county-level COVID-19 infection and mortality information from state and local health agencies. We created prediction models and evaluated their performances on a rolling basis to investigate the evolution of prediction power and risk factors.ResultFrom April 2020 to August 2020, our machine learning model achieved an area under the receiver operating characteristic curve (AUROC) of 0.75, an improvement of over 0.07 from a previously developed machine learning model published by Kidney360 in 2021. As the pandemic evolved, the prediction performance deteriorated and fluctuated more, with the lowest AUROC of 0.6 in December 2021 and January 2022. Over the whole study period, that is, from April 2020 to February 2022, fixing the false-positive rate at 20%, our model was able to detect 40% of the positive patients. We found that features derived from local infection information reported by the Centers for Disease Control and Prevention (CDC) were the most important predictors, and vaccination status was a useful predictor as well. Whether or not a patient lives in a nursing home was an effective predictor before vaccination, but became less predictive after vaccination.ConclusionAs found in our study, the dynamics of the prediction model are frequently changing as the pandemic evolves. County-level infection information and vaccination information are crucial for the success of early COVID-19 prediction models. Our results show that the proposed model can effectively identify SARS-CoV-2 infections during the incubation period. Prospective studies are warranted to explore the application of such prediction models in daily clinical practice.

sTREM-1 as a Predictive Biomarker for Disease Severity and Prognosis in COVID-19 Patients

“…Early research has highlighted the influence of various biomarkers, including C-reactive protein (CRP), procalcitonin (PCT), D-dimer, ferritin, erythrocyte sedimentation rate (ESR), serum ferritin, IL-1, IL-6, IL-8, and IL-18, on the severity of the disease. [14][15][16][17][18][19][20] Triggering receptor expressed on myeloid cells 1 (TREM-1) is a member of the immunoglobulin superfamily, primarily expressed in bone marrow and epithelial cells. 21,22 It is considered an amplifier of inflammation and, when activated, can induce the secretion of cytokines such as TNF-α, IL-6, and IL-1β in monocytes, macrophages, and dendritic cells.…”