When analyzing the thermal stress and deformation of satellites in orbit, the traditional numerical methods, such as the finite difference and the finite element, are expensive and time-consuming. To improve computational efficiency, we propose a deep-learning based surrogate to immediately predict the thermal stress and deformation of a satellite with a given temperature field, where the U-Net is employed to learn the end-to-end mapping from the temperature field to the thermal stress and deformation. A data set with less smooth temperature fields is generated to augment the training data, by which the accuracy and generalization performance of the model is significantly improved. Combined with a rapid temperature prediction method, the model predicts the thermal stress and deformation of a satellite motherboard given several heat sources, verifying the feasibility and effectiveness of the proposed method.