Predicting severity of cochlear hair cell damage in adult chickens using DPOAE input–output functions

Lichtenhan, Jeffery T.; Chertoff, Mark E.; Smittkamp, Susan E.; Durham, Dianne; Girod, Douglas A.

doi:10.1016/j.heares.2004.09.001

Cited by 11 publications

(10 citation statements)

References 47 publications

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“…While one publication found that this intensity difference between the DP and the primary tones was less than what we found (∼50 dB) (ref. 54), a large body of previously published DPOAE data from chickens demonstrate that this difference is similar to what we found, ranging from 60–75 dB (refs 55, 56, 57, 58, 59). Furthermore, it has been well-established that chickens generate DPOAEs that are substantially lower in magnitude than those commonly measured in many laboratory animals, even though the phase characteristics of the DPOAEs among the different species are similar55.…”

Section: Resultssupporting

confidence: 91%

Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla

et al. 2016

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Frequency tuning within the auditory papilla of most non-mammalian species is electrical, deriving from ion-channel resonance within their sensory hair cells. In contrast, tuning within the mammalian cochlea is mechanical, stemming from active mechanisms within outer hair cells that amplify the basilar membrane travelling wave. Interestingly, hair cells in the avian basilar papilla demonstrate both electrical resonance and force-generation, making it unclear which mechanism creates sharp frequency tuning. Here, we measured sound-induced vibrations within the apical half of the chicken basilar papilla in vivo and found broadly-tuned travelling waves that were not amplified. However, distortion products were found in live but not dead chickens. These findings support the idea that avian hair cells do produce force, but that their effects on vibration are small and do not sharpen tuning. Therefore, frequency tuning within the apical avian basilar papilla is not mechanical, and likely derives from hair cell electrical resonance.

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Section: Resultssupporting

confidence: 91%

Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla

et al. 2016

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“…For humans, both the DPOAEs and SFOAEs magnitudes and phase-gradient delays are similar to those described in the literature (Knight and Kemp 2000;Schairer et al 2006). Distortion product magnitudes at 2f 1 − f 2 in the chicken ear (Kettembeil et al 1995;Ipakchi et al 2005;Lichtenhan et al 2005) show some differences across studies (approximately ±7 dB difference in magnitudes). One key difference across chicken studies is the type of anesthesia used, as addressed in the next section.…”

Section: Methodological and Other Issuessupporting

confidence: 78%

Otoacoustic emissions in humans, birds, lizards, and frogs: evidence for multiple generation mechanisms

et al. 2008

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Many non-mammalian ears lack physiological features considered integral to the generation of otoacoustic emissions in mammals, including basilar-membrane traveling waves and hair-cell somatic motility. To help elucidate the mechanisms of emission generation, this study systematically measured and compared evoked emissions in all four classes of tetrapod vertebrates using identical stimulus paradigms. Overall emission levels are largest in the lizard and frog species studied and smallest in the chicken. Emission levels in humans, the only examined species with somatic hair cell motility, were intermediate. Both geckos and frogs exhibit substantially higher levels of high-order intermodulation distortion. Stimulus frequency emission phase-gradient delays are longest in humans but are at least 1 ms in all species. Comparisons between stimulus-frequency emission and distortion-product emission phase gradients for low stimulus levels indicate that representatives from all classes except frog show evidence for two distinct generation mechanisms analogous to the reflection- and distortion-source (i.e., place- and wave-fixed) mechanisms evident in mammals. Despite morphological differences, the results suggest the role of a scaling-symmetric traveling wave in chicken emission generation, similar to that in mammals, and perhaps some analog in the gecko.

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“…The slope value decreases at higher stimulus intensities, especially in the range from 50 dB to 80 dB SPL, where cochlear compression is observed [5]. Although cochlear compression decreases with the increased severity of cochlear lesions, the observed variability makes the DPOAE slope determination a method with high specificity and low sensitivity [6,7]. Gehr et al [8] investigated DPOAE I/O functions in relationship to middle and inner ear alterations in an animal model.…”

Section: Introductionmentioning

confidence: 99%

Alteration of distortion product otoacoustic emission input/output functions in subjects with a previous history of middle ear dysfunction

et al. 2012

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SummaryBackgroundThe aim of this study was to investigate the effects of sub-clinical alterations on the amplitudes and slopes of the DPOAE input-output responses from subjects with previous history of middle ear dysfunction.Material/MethodsThe study included 15 subjects with and 15 subjects without a history of otitis media in the last 10 years. All participants were assessed with acoustic immittance, pure-tone audiometry, and DPOAEs. For the later, I/O functions and I/O slopes were estimated at 1501, 2002, 3174, 4004 and 6384Hz.ResultsNo statistically significant differences were found between the 2 groups in terms of behavioral thresholds. The group with a previous history of middle ear dysfunction presented significantly lower mean DPOAE amplitudes at 2002, 3174 and 4004 Hz. In terms of DPOAE slopes, no statistically significant differences were observed at the tested frequencies, except at 3174 Hz.ConclusionsMiddle ear pathologies can produce subclinical alterations that are undetectable with traditional pure-tone audiometry. The data from the present study show that reduced amplitude DPOAEs are associated with a previous history of middle ear complications. The corresponding DPOAE slopes were affected at only 1 tested frequency, suggesting that the cochlear non-linearity is preserved. Considering these results, it remains to be elucidated to what degree the DPOAE amplitude attenuation interferes with higher-order auditory tasks.

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Predicting severity of cochlear hair cell damage in adult chickens using DPOAE input–output functions

Cited by 11 publications

References 47 publications

Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla

Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla

Otoacoustic emissions in humans, birds, lizards, and frogs: evidence for multiple generation mechanisms

Alteration of distortion product otoacoustic emission input/output functions in subjects with a previous history of middle ear dysfunction

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