Predicting significance of COX-2 expression of peripheral blood monocyte in patients with coronary artery disease

Huang, Qinghua; Fei, Xianming; Li, Shengbing; Cao, Xiaoyang; Tu, Chunping; Jiang, Lei; Wo, Mingyi

doi:10.21037/atm.2019.08.75

Cited by 5 publications

(7 citation statements)

References 23 publications

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“…The nuclear factor kappa-beta (NFKB) is a transcription factor comprising homo- and/or heterodimers formed from distinct proteins, including REL (cRel), Rel A (p65), RELB, NFKB1 (p50 and its precursor p105), and NFKB 2 (p52 and its precursor p100) . Notably, NFKB is also the endpoint of a series of signal transduction events and is involved in many biological processes such as inflammation and immunity.…”

Section: Discussionmentioning

confidence: 99%

“…41 The nuclear factor kappa-beta (NFKB) is a transcription factor comprising homo-and/or heterodimers formed from distinct proteins, including REL (cRel), Rel A (p65), RELB, NFKB1 (p50 and its precursor p105), and NFKB 2 (p52 and its precursor p100). 42 Notably, NFKB is also the endpoint of a series of signal transduction events and is involved in many biological processes such as inflammation and immunity. Adequate research studies have described the connection of NFKB-related receptor and CVD 43,44 because it regulated many of the proinflammatory genes related to atherosclerosis by inhibiting its role in vascular inflammation, proliferation of vascular smooth muscle cells, or foam cell formation.…”

Section: Discussionmentioning

confidence: 99%

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Study on the Active Constituents and Molecular Mechanism of Zhishi Xiebai Guizhi Decoction in the Treatment of CHD Based on UPLC-UESI-Q Exactive Focus, Gene Expression Profiling, Network Pharmacology, and Experimental Validation

Liu

et al. 2022

ACS Omega

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As one of the most common clinical cardiovascular diseases (CVDs), coronary heart disease (CHD) is the most common cause of death in the world. It has been confirmed that Zhishi Xiebai Guizhi decoction (ZXGD), a classical prescription of the traditional Chinese medicine (TCM), has achieved certain effects in the treatment of CHD; however, the mechanism still remains controversial. In this paper, an integrated approach, including UPLC-UESI-Q Exactive Focus, gene expression profiling, network pharmacology, and experimental validation, was introduced to systematically investigate the mechanism of ZXGD in the treatment of CHD. First, UPLC-UESI-Q Exactive Focus was applied to identify the chemical compounds of ZXGD. Then, the targets of the components for ZXGD were predicted by MedChem Studio software embed in the integrative pharmacology-based research platform of TCM, and the differentially expressed genes (DEGs) of CHD were obtained by gene expression profiling in gene expression omnibus database. The common genes of the above two genes were obtained by Venn analysis as the targets of GXGD in treatment with CHD. Third, the core targets were screened out by protein–protein interaction network analysis, and the kyoto encyclopedia of genes and genomes pathway enrichment analysis was performed by the database for annotation, visualization, and integrated discovery bioinformatics resources. After that, the formula–herb–compound–target–pathway network was constructed to explore the mechanism of ZXGD in the treatment of CHD. Finally, molecular docking and the vitro experiment were carried out to validate some key targets. As a result, a total of 39 compounds, 12 core targets, and 4 pathways contributed to ZXGD for the treatment of CHD. This study preliminarily provided a foundation for the study on the mechanism against CHD for ZXGD and may be a reference for the compatibility mechanism and the extended application of TCM compound prescription.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Study on the Active Constituents and Molecular Mechanism of Zhishi Xiebai Guizhi Decoction in the Treatment of CHD Based on UPLC-UESI-Q Exactive Focus, Gene Expression Profiling, Network Pharmacology, and Experimental Validation

Liu

et al. 2022

ACS Omega

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“…COX-2, mPGES-1, EP-3, and EP-4 mRNA expression and PGE2 levels are increased in PBMC of patients with coronary artery disease than healthy volunteers, suggesting that circulating monocytes are activated [ 272 ]. Thus, COX-2-mediated PGE 2 overproduction by stimulated monocytes might provide a new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors [ 273 ].…”

Section: Lipid Metabolitesmentioning

confidence: 99%

Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases

Strassheim

Sullivan

Irwin

et al. 2021

Cells

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G protein-coupled receptors (GPCRs) have originally been described as a family of receptors activated by hormones, neurotransmitters, and other mediators. However, in recent years GPCRs have shown to bind endogenous metabolites, which serve functions other than as signaling mediators. These receptors respond to fatty acids, mono- and disaccharides, amino acids, or various intermediates and products of metabolism, including ketone bodies, lactate, succinate, or bile acids. Given that many of these metabolic processes are dysregulated under pathological conditions, including diabetes, dyslipidemia, and obesity, receptors of endogenous metabolites have also been recognized as potential drug targets to prevent and/or treat metabolic and cardiovascular diseases. This review describes G protein-coupled receptors activated by endogenous metabolites and summarizes their physiological, pathophysiological, and potential pharmacological roles.

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“…Such data would indicate a gut dysbiosis relevant modulation of these crucial cells in cancers and SARS-CoV-2 infection. Butyrate also inhibits cells involved in the ‘cytokine storm’, including macrophages and neutrophils [ 104 ], with its inhibition of COX2-driven attachment of monocytes to endothelial cells [ 105 ], indicating an impact of butyrate on embolism formation and atherosclerosis [ 106 ]. In the lung, butyrate suppresses HMGB1 induction to infection, suggesting that it will act to prevent the HMGB1 inhibition of RvD1 and the RvD1 resolution of activated neutrophils [ 76 ].…”

Section: Ahr and Wider Covid-19 Pathophysiologymentioning

confidence: 99%

Aryl Hydrocarbon Receptor Role in Co-Ordinating SARS-CoV-2 Entry and Symptomatology: Linking Cytotoxicity Changes in COVID-19 and Cancers; Modulation by Racial Discrimination Stress

Anderson¹,

Carbone

Mazzoccoli

2020

Biology

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There is an under-recognized role of the aryl hydrocarbon receptor (AhR) in co-ordinating the entry and pathophysiology of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) that underpins the COVID-19 pandemic. The rise in pro-inflammatory cytokines during the ‘cytokine storm’ induce indoleamine 2,3-dioxygenase (IDO), leading to an increase in kynurenine that activates the AhR, thereby heightening the initial pro-inflammatory cytokine phase and suppressing the endogenous anti-viral response. Such AhR-driven changes underpin the heightened severity and fatality associated with pre-existent high-risk medical conditions, such as type II diabetes, as well as to how racial discrimination stress contributes to the raised severity/fatality in people from the Black Asian and Minority Ethnic (BAME) communities. The AhR is pivotal in modulating mitochondrial metabolism and co-ordinating specialized, pro-resolving mediators (SPMs), the melatonergic pathways, acetyl-coenzyme A, and the cyclooxygenase (COX) 2-prostaglandin (PG) E2 pathway that underpin ‘exhaustion’ in the endogenous anti-viral cells, paralleling similar metabolic suppression in cytolytic immune cells that is evident across all cancers. The pro-inflammatory cytokine induced gut permeability/dysbiosis and suppression of pineal melatonin are aspects of the wider pathophysiological underpinnings regulated by the AhR. This has a number of prophylactic and treatment implications for SARS-CoV-2 infection and cancers and future research directions that better investigate the biological underpinnings of social processes and how these may drive health disparities.

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Predicting significance of COX-2 expression of peripheral blood monocyte in patients with coronary artery disease

Cited by 5 publications

References 23 publications

Study on the Active Constituents and Molecular Mechanism of Zhishi Xiebai Guizhi Decoction in the Treatment of CHD Based on UPLC-UESI-Q Exactive Focus, Gene Expression Profiling, Network Pharmacology, and Experimental Validation

Study on the Active Constituents and Molecular Mechanism of Zhishi Xiebai Guizhi Decoction in the Treatment of CHD Based on UPLC-UESI-Q Exactive Focus, Gene Expression Profiling, Network Pharmacology, and Experimental Validation

Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases

Aryl Hydrocarbon Receptor Role in Co-Ordinating SARS-CoV-2 Entry and Symptomatology: Linking Cytotoxicity Changes in COVID-19 and Cancers; Modulation by Racial Discrimination Stress

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