Predicting Subtypes of Thymic Epithelial Tumors Using CT: New Perspective based on a Comprehensive Analysis of 216 Patients

Hu, Yu-Chuan; Wu, Lang; Yan, Lin‐Feng; Wang, Wen; Wang, Shumei; Chen, Baoying; Li, Gangfeng; Zhang, Bei; Cui, Guangbin

doi:10.1038/srep06984

Cited by 39 publications

(53 citation statements)

References 25 publications

(43 reference statements)

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“…The qualitative data, presented as a number (%), were also analyzed using a χ 2 test. The quantitative data, expressed as the mean ± SD, were determined using a Kolmogorov-Smirnov test with one-way ANOVA (Hu et al, 2014). P < 0.05 was considered to be statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

Nie

Wang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Polymorphisms in the CD226 gene have been reported to be associated with autoimmune diseases. The aim of our study was to investigate the association between two single nucleotide polymorphisms (SNPs) (rs763361 and rs727088) in the CD226 gene and the risk for developing type 1 diabetes (T1D) in Chinese Han children. This case-control study included a total of 152 Chinese children with T1D and 304 matchedpair, healthy controls based on age and gender. The genetic variants of the rs763361 and rs727088 SNPs in the CD226 gene were determined using the polymerase chain reaction and restriction fragment length polymorphism method. The CD226 rs763361 polymorphism increased the risk of T1D in the genotype [P < 0.001, odds ratio (OR) = 3.9, 95% confidence interval (CI) = 2.24-6.76], dominant (P < 0.001, OR = 2.1, 95%CI = 1.40-3.14), and recessive (P < 0.001, OR = 0.5, 95%CI = 0.30-0.84) models. Additionally, the carriers of the T allele were more susceptible to T1D (P < 0.001, OR = 2.1, 95%CI = 1.58-2.79). Carriers of the T allele who were younger than 10 years of age at disease onset had an increased risk of T1D than those who were older at the disease onset. However, there was no association between the CD226 rs727088 SNP and risk for developing T1D. These findings revealed that CD226 rs763361 polymorphism was significantly associated with susceptibility to T1D and that the presence of the T allele might be a genetic factor for susceptibility to T1D.

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Section: Discussionmentioning

confidence: 99%

Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

Nie

Wang

et al. 2015

Genet. Mol. Res.

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“…To identify other prognostic factors for thymoma, the associations between the CT findings of thymomas and their histological stages according to the WHO classification have been examined by several investigators (6,(9)(10)(11)(12)(13). One of the latter studies reported that smooth contours and a round shape were most suggestive of type A thymoma, whereas calcifications were indicative of type B thymoma.…”

Section: Contrast Enhancement Patternmentioning

confidence: 99%

“…In some of the latter reports, the investigators classified thymomas into low-risk and high-risk lesions, which are equivalent to type A-B1 and B2 or B3 lesions, respectively (11,12). However, only a few studies about CT characteristics of low-and high-risk thymomas have been reported so far (11)(12)(13). So, the purpose of this study was to evaluate the associations between CT findings of thymomas and their classification according to the Masaoka staging system and the WHO classification, i.e.…”

Section: Introductionmentioning

confidence: 99%

Associations between computed tomography features of thymomas and their pathological classification

et al. 2016

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Background Thymoma exhibits a range of histological and biological features and their imaging findings varies. Purpose To evaluate the associations between CT findings of thymomas and their classification according to the Masaoka staging system and World Health Organization (WHO) classification. Material and Methods Eighty-four patients with thymoma were evaluated. Comparisons between the CT findings of Masaoka stage I/II and III/IV lesions, and the WHO type A-B1 (low risk) and B2/B3 (high risk) lesions were performed. Results Stage III/IV thymomas (mean size, 60 mm) were significantly larger than stage I/II (45 mm) lesions and had more irregular shape and contour. Necrosis and calcification were observed in 16 (59%) and nine (33%) stage III/IV thymomas, and 16 (28%) and seven (12%) stage I/II lesions, respectively. Regarding the WHO classification, the high-risk thymomas displayed irregular shape and contour more often than low-risk lesions. There were significant differences between the patterns of mediastinal invasion seen in high- and low-risk groups; 21 (68%) vs. six (12%) lesions demonstrated mediastinal fat invasion, seven (23%) vs. two (4%) lesions exhibited great vessel invasion, five (16%) vs. 0 (0%) lesions displayed pericardial invasion, and 18 (58%) vs. 10 (20%) lesions invaded the lungs, respectively. Conclusion Masaoka stage III/IV thymomas were larger in size, had more irregular shape and contour, and exhibited necrosis and calcification more often than the stage I/II lesions. In the WHO classification, high-risk thymomas demonstrated more irregular shape and contour than low-risk thymomas.

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“…DECT perfusion imaging can provide perfusion and spectral parameters from tumours simultaneously through a one-stop CT perfusion scan in GSI mode. In the recent literature, there is no study concerning the differences in perfusion or/and spectral parameters among the six WHO pathological subtypes, whereas a large number of studies www.nature.com/scientificreports www.nature.com/scientificreports/ comparing LRT (Types A, AB and B1), HRT (Types B2, B3) and TC have been conducted [16][17][18][19][20][21][22][23] . In our study, quantitative analyses of the majority of perfusion and spectral parameter values revealed differences between the different WHO pathological subtypes, especially between Type A or AB and Type B (B1, B2, B3) or TC.…”

Section: Discussionmentioning

confidence: 99%

“…www.nature.com/scientificreports www.nature.com/scientificreports/ The six different TET subtypes have different biological characteristics and invasiveness and were divided into three subgroups according to increasing grade of malignancy-low-risk thymoma (LRT; Types A, AB and B1), high-risk thymoma (HRT; Types B2 and B3), and TC-in 2004 20 . Only one study 21 has reported the comparison between low-risk (Types A and AB) and high-risk (Types B1, B2, B3 and TC) TETs using conventional enhancement CT. However, a large number of studies have compared LRT (Types A, AB, and B1), HRT (Type B2, B3), and TC [22][23][24] .…”

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confidence: 99%

Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors

Zhang

et al. 2020

Sci Rep

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To evaluate the role of conventional contrast-enhanced CT (CECT) imaging and dual-energy spectral CT (DECT) perfusion imaging in differentiating the WHO histological subtypes of thymic epithelial tumours (TETs). Eighty-eight patients with TETs who underwent DECT perfusion scans (n = 51) and conventional CT enhancement scans (n = 37) using a GE Discovery CT750 HD scanner were enrolled in this study. The mean maximal contrast-enhanced range (mean CEmax) and the perfusion and spectral parameters of the lesions were analysed. Among the six WHO subtypes (Type A, AB, B1, B2, and B3 thymoma and thymic carcinoma), the mean CEmax values and most of the perfusion and spectral parameter values of Type A and Type AB were significantly higher than those of the other subtypes (all P < 0.05), and there was no difference among Type B1, B2 and B3 (all P > 0.05). The mean CEmax value was not different between Type B (including Type B1, B2, and B3) and thymic carcinoma (P = 1.000). The PS, IC, NIC and λ HU values in the optimal venous phase of thymic carcinoma were higher than those of Type B (all p < 0.05). The parameters of conventional CECT imaging and DECT perfusion imaging can help identify the subtype of TETs, especially those of DECT perfusion imaging in type B thymomas and thymic carcinomas.

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Predicting Subtypes of Thymic Epithelial Tumors Using CT: New Perspective based on a Comprehensive Analysis of 216 Patients

Cited by 39 publications

References 25 publications

Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children

Associations between computed tomography features of thymomas and their pathological classification

Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors

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