This study examined how amor fati, a positive psychological construct, was associated with suicidal ideation in a sample of 215 young adults. Specifically, components of existential meaning in life (viz., comprehension, purpose, and mattering) and regret were evaluated as potential mediators of the association between amor fati and suicidal ideation. Results of conducting bootstrapped mediation testing with multiple mediators indicated that amor fati was indirectly associated with suicidal ideation through comprehension and mattering. Purpose and regret were not found to mediate the association between amor fati and suicidal ideation. In support of partial mediation, however, the negative association between amor fati and suicidal ideation remained significant even after including components of existential meaning in life and regret in the model. The present findings indicate that amor fati is an important protective factor that should be considered in studies of suicidality in young adults.