2020
DOI: 10.1002/slct.202001780
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Predicting the Cardiac Troponin I (cTnl) Aptamer/Methylene Blue Configuration Using Computational Modeling Studies: A Screening Search Method for Constructing Aptasensors

Abstract: Acute Myocardial Infarction (AMI) is the most common cause of mortality, and cardiac troponin I (cTnI) is the gold standard for AMI diagnosis. Some aptamers have been reported to detect cTnI, but there is rarely any structural information on their binding with cTnI. There are many studies involving electrochemical aptasensors with methylene blue (MB) as a redox indicator that does not provide any significant new information. Our study, however, involves the computational modeling of the complexes of a document… Show more

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Cited by 4 publications
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“…6 Currently, the main methods for cTnI detection include enzyme-linked immunosorbent assay (ELISA), solid-phase immunoassay, radioimmunoassay, chemiluminescence analysis, and others. [7][8][9] However, these methods have several limitations during application, for instance a cumbersome procedure, long detection time, and sensitivity limitation. 10 Therefore, it is of significant importance to develop highly sensitive, specific, and rapid methods for cTnI detection, to promote the early diagnosis of AMI.…”
Section: Introductionmentioning
confidence: 99%
“…6 Currently, the main methods for cTnI detection include enzyme-linked immunosorbent assay (ELISA), solid-phase immunoassay, radioimmunoassay, chemiluminescence analysis, and others. [7][8][9] However, these methods have several limitations during application, for instance a cumbersome procedure, long detection time, and sensitivity limitation. 10 Therefore, it is of significant importance to develop highly sensitive, specific, and rapid methods for cTnI detection, to promote the early diagnosis of AMI.…”
Section: Introductionmentioning
confidence: 99%