Predicting the clinical outcome of ICSI by sperm head vacuole examination

Pocate-Cheriet, Khaled; Heilikman, I.; Porcher, Raphaël; Barraud-Lange, Virginie; Sermondade, Nathalie; Herbemont, C.; Wolf, Jean Philippe; Sifer, C.

doi:10.1080/19396368.2016.1261203

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…Our results are also in agreement with other reports that could not find a direct correlation between seminal parameters and ICSI outcomes (Nagy et al ., ; Gao et al ., ; Pocate‐Cheriet et al ., ), which reinforces the assertion that MSOME must be incorporated on regular seminal analysis for a better prediction of semen normality and ICSI outcomes. Gao et al .…”

Section: Discussionsupporting

confidence: 77%

“…In an opposite way, Pocate‐Cheriet et al . () could not find any correlations of MSOME with seminal parameters and ICSI outcomes. This result may be related to the analyzed population of exclusively severe male infertility factors, which had a 10 times higher percentage of MSOME Grade III in comparison with our sample, and may also be a consequence of the lack of adjustment for confounder variables that may introduce a bias, that is, ejaculatory abstinence, male and female age, and cycle outcomes.…”

Section: Discussionmentioning

confidence: 72%

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Sperm morphological normality under high magnification is correlated to male infertility and predicts embryo development

et al. 2018

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Human sperm morphology has been described as an essential parameter for the diagnosis of male infertility and a prognostic indicator of natural or assisted pregnancies. Nevertheless, standard morphological assessment remains a subjective analysis and its impact on intracytoplasmic sperm injection (ICSI) is also of limited value. The objective of this prospective cohort study was to investigate whether motile sperm organelle morphology examination (MSOME) can improve semen analysis by better defining male infertility and providing a better prognosis for ICSI up to a year later. Data were obtained from 483 patients undergoing conventional semen analysis from June 2015 to June 2017 in a private university-affiliated in vitro fertilization (IVF) center. The correlation of MSOME with seminal parameters was evaluated. One hundred and thirty patients underwent ICSI up to a year later, and the correlation between MSOME and ICSI outcomes was established. Except for volume, all seminal parameters were positively correlated with MSOME I+II. MSOME was also distinct between World Health Organization (WHO) classification groups, with normozoospermic and oligoasthenoteratozoospermic presenting the higher and the lower proportion of MSOME I+II, respectively. MSOME I+II was prognostic for fertilization rate, high-quality cleavage-stage embryos rate, and blastocyst rate. The normality cutoff value based on blastocyst rate was MSOME I+II≥ 5.5%. MSOME could be a useful tool for the diagnosis of infertility severity as it is correlated with sperm morphology, motility, and concentration. Men who had higher MSOME I+II had better ICSI outcomes. The future use of MSOME as a routine method for semen analysis may be a reliable form of assessing male infertility.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 72%

Sperm morphological normality under high magnification is correlated to male infertility and predicts embryo development

et al. 2018

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“…Nevertheless, standard semen parameters provide a crude prediction of the male factor fertility potential and its implications on reproductive outcomes (10)(11)(12), since nearly 15% of infertile men have semen parameters within normal reference ranges (5). It has been suggested that there must exist subcellular or nuclear factors that are not identified in conventional semen analysis, which may contribute to male factor infertility (5).…”

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confidence: 99%

Sperm DNA fragmentation is correlated with poor embryo development, lower implantation rate, and higher miscarriage rate in reproductive cycles of non–male factor infertility

Borges

Zanetti

Setti

et al. 2019

Fertility and Sterility

113

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Objective: To study the implications of sperm DNA fragmentation (SDF) in intracytoplasmic sperm injection cycles for non-male factor infertility. Design: Prospective cohort study. Setting: Private university-affiliated IVF center. Patient(s): Data from 475 cycles performed from June 2016 to June 2017. Intervention(s): Cycles were divided according to SDF rate into two groups: <30% SDF (n ¼ 433) and R30% SDF (n ¼ 42). Laboratory and clinical outcomes were compared between groups by generalized linear models adjusted for potential confounders. Main Outcome Measure(s): Embryo quality and miscarriage rates. Result(s): Fertilization rate was similar between groups (R30% SDF, 85.28% AE 1.06% vs. <30% SDF, 90.68% AE 3.61%). Significantly lower rates of normal cleavage speed (R30% SDF, 61.12% AE 4.21% vs. <30% SDF, 72.53% AE 1.24%), high-quality embryos at day 3 (R30% SDF, 23.07% AE 5.56% vs. <30% SDF, 36.41% AE 1.53%), blastocyst formation (R30% SDF, 39.09% AE 2.73% vs. <30% SDF, 58.83% AE 7.59%), blastocyst quality (R30% SDF, 11.97% AE 1.22% vs. <30% SDF, 30.09% AE 2.39%), and implantation (33.24% AE 1.66% vs. <30% SDF, 46.40% AE 4.61%) were observed in cycles with higher SDF, despite similar pregnancy rates (R30% SDF, 30.40% vs. <30% SDF, 32.40%). A 2.5-fold miscarriage rate was observed in cycles with an SDF above the established cutoff (R30% SDF, 42.8% vs. <30% SDF, 16.8%). Conclusion(s):Higher SDF is correlated with poor embryo development, lower implantation rate, and higher miscarriage rate in nonmale factor infertility intracytoplasmic sperm injection cycles. Since defects in sperm may be hidden, the SDF test can bring additional information to the sperm quality evaluation of men with unknown infertility history. (Fertil Steril Ò 2019;112:483-90. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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“…Previous studies were contradictory and failed to identify a positive predictive value for routine semen parameters in ICSI outcomes, with no consensus on cutoff values predicting success [12,19]. This may be explained by differences among these studies in terms of the retrospective study design, etiology of infertility in the investigated infertile couples, or the edition of the WHO guidelines that was used.…”

Section: Discussionmentioning

confidence: 99%

Semen parameters on the intracytoplasmic sperm injection day: Predictive values and cutoff thresholds of success

Moubasher

Taha

El-Nashar

et al. 2021

Clin Exp Reprod Med

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Objective: This study was conducted to investigate the relationship of semen parameters in samples used for intracytoplasmic sperm injection (ICSI) with fertilization and pregnancy rates in infertile couples.Methods: In this prospective study of Infertile couples with male factor infertility that had undergone ICSI, fractions of the same semen samples obtained for microinjection (to ensure the best predictability) were evaluated to determine the semen parameters and sperm DNA fragmentation index (DFI) on the day of oocyte recovery.Results: In total, 120 couples completed the study and were subdivided into fertilized (n=87) and non-fertilized couples (n=33). The fertilized couples were further classified into pregnant (n=48) and non-pregnant (n=39) couples. Compared to non-fertilized and non-pregnant couples, fertilized and pregnant couples showed statistically significantly higher sperm viability and percentage of normal sperm morphology, as well as significantly lower sperm DFI values. A receiver operating characteristic curve analysis of data from the 120 ICSI cycles showed that sperm viability, normal sperm morphology percentages, and sperm DFI were significant prognostic indicators of fertilization at cutoff values of 40%, 7%, and 46%, respectively. A sperm DFI of 46% showed sensitivity and specificity of 95% and 90%, respectively, for predicting fertilization, and no clinical pregnancies occurred in couples with a sperm DFI above 46%.Conclusion: Semen parameters from the ICSI day sample, especially sperm viability, normal morphology, and DFI, had an impact on fertilization and pregnancy outcomes in ICSI cycles.

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Predicting the clinical outcome of ICSI by sperm head vacuole examination

Cited by 9 publications

References 29 publications

Sperm morphological normality under high magnification is correlated to male infertility and predicts embryo development

Sperm morphological normality under high magnification is correlated to male infertility and predicts embryo development

Sperm DNA fragmentation is correlated with poor embryo development, lower implantation rate, and higher miscarriage rate in reproductive cycles of non–male factor infertility

Semen parameters on the intracytoplasmic sperm injection day: Predictive values and cutoff thresholds of success

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