Background: Self-management skills (SMS) are vital for all managers to increase managerial performance and Well-Being (WB), yet few studies have been conducted in Nepal regarding this topic. Purpose: The main aim of this paper is to explore the relationship between Self- Management Skills (SMS) and Demographic Factors (DF) among managers in Kathmandu- based organizations. Methods: The study utilized a convenience sampling approach and a cross-sectional method with respondents (n=429)- managers, employing online questionnaires due to COVID-19. The study was tested for reliability and validity. SMS questions with five-point scales were used, resulting in 50 Self-Management Skills Scores (SMSS). A score of > 25 indicated a high score, while <25 indicated below-average scores. Descriptive and regression analyses were used to analyze the data. Findings: The results revealed that 63.1% of the managers had Self-Management Skills Scores (SMSS) below the average level. Demographic factors such as age, gender, and SMS training were correlated with SMS. Research limitations/Practical Implications: There are limitations with self-reported data, single data collection, and unknown total population. According to the study, managers’ SMS competence is influenced by their SMS training, age, and gender. Organizations should invest in training and development to improve managerial skills, especially in the healthcare sector. Diversity, Equity, and Inclusiveness (DEI)-related initiatives and improved hiring practices should be given primary priority. Originality/Value: This research explores a deserved need to learn how SMS can help create a person’s nurturing personality.