Predicting the likelihood of live birth for elective oocyte cryopreservation: a counseling tool for physicians and patients

Goldman, Randi H.; Racowsky, Catherine; Farland, Leslie V.; Munné, S.; Fox, Janis H.

doi:10.1016/j.fertnstert.2016.07.095

Cited by 16 publications

(27 citation statements)

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“…Around one‐third (n = 29; 35%) of respondents were unsure. Following calculation of each individual probability of achieving at least 1 live birth, using the counseling tool described by Goldman et al, which incorporates the number of oocytes stored and the age at the time of treatment, 12% (n = 10) correctly estimated their chances of achieving a live birth. However, 8% (n = 10) overestimated their chances and 42% (n = 34) underestimated their chances of achieving a live birth.…”

Section: Resultsmentioning

confidence: 99%

Perceptions, outcomes, and regret following social egg freezing in the UK; a cross‐sectional survey

Jones

Kasaven

L’Heveder

et al. 2019

Acta Obstet Gynecol Scand

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Introduction Social egg freezing enhances reproductive autonomy by empowering women with the capacity to delay their childbearing years, while preserving the opportunity to maintain biological relation with subsequent offspring. However, age‐related obstetric complications, economic implications and the risk of unsuccessful future treatment make it a controversial option. Despite the upward trend in women electively cryopreserving their eggs, there is limited data about the women’s perceptions, having undergone the process. The aim of this study was to investigate the motivations of women who have undergone social egg freezing, identify their perceptions following treatment, and assess potential feelings of regret. Material and methods This cross‐sectional survey, based at a fertility clinic in the UK, used an electronic questionnaire to assess the motivations and perceptions of women who underwent social egg freezing between 1 January 2008 and 31 December 2018. Results One hundred questionnaires were distributed, and 85 women responded (85% response rate). The most frequent reason for freezing oocytes was not having a partner with 56 (70%) women saying it “definitely” influenced their decision. The majority of women (83%; n = 68) knew there was a chance of treatment failure in the future and that a live birth could not be guaranteed. More than half (n = 39; 51%) disagreed or strongly disagreed that the 10‐year UK storage limit is fair. One‐third of respondents (n = 17; 33%) felt the storage time should be indefinite and 29% (n = 15) believed it should be up to the age of 50. Twenty percent (n = 15) of the women who underwent social egg freezing have successfully had a baby or are currently pregnant, half (n = 8; 53%) of whom conceived spontaneously and a quarter (n = 4; 26%) used their stored oocytes. In all, 91% (n = 73) had no regrets over their decision to undergo social egg freezing. Conclusions We demonstrate herein important and novel insights into the motivations and perceptions of women from a UK population who have undergone social egg freezing. Despite potential physical, psychological, and financial burdens, only a small minority of women experience regret after social egg freezing. We also highlight clear discontent with the Human Fertilisation & Embryology Authority storage limit among social egg freezers in the UK.

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Section: Resultsmentioning

confidence: 99%

Perceptions, outcomes, and regret following social egg freezing in the UK; a cross‐sectional survey

Jones

Kasaven

L’Heveder

et al. 2019

Acta Obstet Gynecol Scand

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“…Recently, a mathematical model has been developed to predict the probability of live birth based on the number of cryopreserved oocytes taking into consideration female age . According to this model, women at 34, 37 or 42 years would need to cryopreserve 10, 20 and 61 oocytes, respectively, to obtain a 75% likelihood of having at least one live birth .…”

Section: Efficacy Of Social Egg Freezingmentioning

confidence: 99%

Elective egg freezing without medical indications

Alteri

Pisaturo²,

Nogueira

et al. 2019

Acta Obstet Gynecol Scand

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The aim of this review is to provide current knowledge on fertility preservation for non‐medical reasons in women willing to postpone childbearing. The topic is highly debatable, starting from disagreement about its terminology, the number of eggs necessary to predict chances of success, and the safety and socio/ethical point of view. Cost analysis and discrepancies among countries’ recommendations and regulations are described to confirm the controversies and unsolved issues around this very interesting topic. Finally, an overview on the returning rate of women among “egg bankers” and reasons behind their decisions are illustrated.

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“…16 The majority of participants (68%) were aged 40-44 years at the time of breast cancer diagnosis and therefore practitioners may have been less likely to discuss fertility preservation due to lower success rates with oocyte cryopreservation in older women. 58 Selection bias in this volunteer cohort is possible; however, a low prevalence of receipt of fertility counseling among a relatively well-educated and high-resourced sample is in addition concerning for what this prevalence may be among women with fewer resources. The population in the current study was largely non-Hispanic white and estimates were adjusted for age only, leaving the potential for residual confounding or incomplete assessment of the experience of minority women.…”

Section: Discussionmentioning

confidence: 96%

“…The findings of the current study may be limited by recall, whereby some women who discussed fertility do not recall this discussion due to the overwhelming gravity, complexity, or sheer volume of medical information shared with patients around the time of a cancer diagnosis . The majority of participants (68%) were aged 40‐44 years at the time of breast cancer diagnosis and therefore practitioners may have been less likely to discuss fertility preservation due to lower success rates with oocyte cryopreservation in older women . Selection bias in this volunteer cohort is possible; however, a low prevalence of receipt of fertility counseling among a relatively well‐educated and high‐resourced sample is in addition concerning for what this prevalence may be among women with fewer resources.…”

Section: Discussionmentioning

confidence: 99%

Fertility‐related experiences after breast cancer diagnosis in the Sister and Two Sister Studies

Bressler

Mersereau

Anderson

et al. 2019

Cancer

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Background Commonly used chemotherapies can be toxic to the ovaries. To the authors’ knowledge, the majority of studies evaluating receipt of fertility counseling for women in their reproductive years have been performed in specific settings, thereby limiting generalizability. Methods A nationwide sample of US women diagnosed with breast cancer before age 45 years completed a survey assessing the prevalence of fertility counseling. Age‐adjusted log‐binomial regression was used to estimate prevalence ratios (PRs) and 95% CIs for fertility counseling. Results Among 432 survivors diagnosed between 2004 and 2011, 288 (67%) had not discussed the effects of treatment on fertility with a health care provider before or during treatment. Fertility discussion was associated with younger age (PR, 3.49 [95% CI, 2.66‐4.58] for aged <35 years vs ≥40 years) and lower parity (PR, 1.81 [95% CI, 1.29‐2.53] for parity 1 vs 2). Approximately 20% of respondents reported that they were interested in future fertility (87 of 432 respondents) at the time of their diagnosis, but not all of these individuals (66 of 87 respondents) received counseling regarding the impact of treatment on their fertility, and few (8 of 87 respondents) used fertility preservation strategies. Among 68 women with a fertility interest who provided reasons for not taking steps to preserve fertility, reasons cited included concern for an adverse impact on cancer treatment (56%), lack of knowledge (26%), decision to not have a child (24%), and cost (18%). Conclusions Across multiple treatment settings, the majority of women of reproductive age who are diagnosed with breast cancer did not discuss fertility with a health care provider or use fertility preservation strategies. Discussing the potential impact of cancer treatment on future fertility is an important aspect of patient education.

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Predicting the likelihood of live birth for elective oocyte cryopreservation: a counseling tool for physicians and patients

Cited by 16 publications

References 0 publications

Perceptions, outcomes, and regret following social egg freezing in the UK; a cross‐sectional survey

Perceptions, outcomes, and regret following social egg freezing in the UK; a cross‐sectional survey

Elective egg freezing without medical indications

Fertility‐related experiences after breast cancer diagnosis in the Sister and Two Sister Studies

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