Predicting the long-term impact of acquired severe injuries on functional health status: the role of optimism, emotional distress and pain

Vassend, Olav; Aj, Quale; Røise, Olav; Ak, Schanke

doi:10.1038/sc.2011.70

Cited by 24 publications

(16 citation statements)

References 19 publications

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“…52,74,86 Unfortunately, many pharmacological and non-pharmacological treatments are tried with only limited success. 7,11,55,77,80 To improve the management of these refractory pain types, a better understanding of the mechanisms responsible for the development and maintenance of neuropathic pain is needed.…”

Section: Discussionmentioning

confidence: 99%

Somatosensory phenotype is associated with thalamic metabolites and pain intensity after spinal cord injury

Widerström-Noga

Cruz-Almeida

Felix

et al. 2015

Pain

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Neuropathic pain is one of the most difficult consequences of spinal cord injury (SCI). The clinical correlates of the underlying mechanisms responsible for neuropathic pain are not well understood, although methods such as quantitative somatosensory testing (QST) or brain imaging have been used to further a mechanism-based understanding of pain. Our previous SCI study demonstrated a significantly lower glutamate-glutamine/myo-inositol ratio (Glx/Ins) in the anterior cingulate cortex in persons with severe neuropathic pain compared with those with less severe neuropathic pain or pain-free, able-bodied controls, suggesting that a combination of decreased glutamatergic metabolism and glial activation may contribute to the development of severe neuropathic pain after SCI. The present study aimed to determine the relationships between somatosensory function below the level of injury and low thalamic Glx/Ins in persons with intense neuropathic pain after SCI. Participants underwent QST and a 3 Tesla proton magnetic resonance spectroscopy. A cluster analysis including SCI participants resulted in 1 group (n = 19) with significantly (P < 0.001) greater pain intensity (6.43 ± 1.63; high neuropathic pain [HNP], and lower Glx/Ins [1.22 ± 0.16]) and another group (n = 35) with lower pain intensity ratings (1.59 ± 1.52, low neuropathic pain [LNP], and higher Glx/Ins [1.47 ± 0.26]). After correcting for age, QST indicated significantly greater somatosensory function in the HNP group compared with the LNP group. Our results are consistent with research suggesting that damage to, but not abolition of, the spinothalamic tract contributes to development of neuropathic pain after SCI and that secondary inflammatory processes may amplify residual spinothalamic tract signals by facilitation, disinhibition, or sensitization.

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Section: Discussionmentioning

confidence: 99%

Somatosensory phenotype is associated with thalamic metabolites and pain intensity after spinal cord injury

Widerström-Noga

Cruz-Almeida

Felix

et al. 2015

Pain

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“…A number of authors have linked pain to emotional distress (depression and anxiety), 4,8,11,16,17 where it is known from other research that pain tends to be the cause, rather than the effect, in such coupling. The presence of pain also may have a variety of impacts on the rehabilitation process itself.…”

Section: ª 2013 By the American Congress Of Rehabilitation Medicinementioning

confidence: 97%

Pain and Its Impact on Inpatient Rehabilitation for Acute Traumatic Spinal Cord Injury: Analysis of Observational Data Collected in the SCIRehab Study

Zanca¹,

Dijkers²,

Horn³

2013

Archives of Physical Medicine and Rehabilitation

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“…Chronic pain has been proposed as a crucial risk factor in that it prevents long-term adaptation [8] and potentially worsens the disability associated with SCI [9]. Chronic pain has been reported in up to 94% of individuals after SCI, and the majority of SCI individuals reported more than one pain issue [10,11].…”

Section: Introductionmentioning

confidence: 99%

The moderation of resilience on the negative effect of pain on depression and post-traumatic growth in individuals with spinal cord injury

Min

Lee

Hwang

et al. 2013

Disability and Rehabilitation

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Predicting the long-term impact of acquired severe injuries on functional health status: the role of optimism, emotional distress and pain

Cited by 24 publications

References 19 publications

Somatosensory phenotype is associated with thalamic metabolites and pain intensity after spinal cord injury

Somatosensory phenotype is associated with thalamic metabolites and pain intensity after spinal cord injury

Pain and Its Impact on Inpatient Rehabilitation for Acute Traumatic Spinal Cord Injury: Analysis of Observational Data Collected in the SCIRehab Study

The moderation of resilience on the negative effect of pain on depression and post-traumatic growth in individuals with spinal cord injury

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