2000
DOI: 10.1016/s0090-4295(00)00672-5
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Predicting the outcome of prostate biopsy in screen-positive men by a multilayer perceptron network

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Cited by 134 publications
(80 citation statements)
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“…33 A further improvement for better discrimination between PCa and BPH are the so-called artificial neural networks, which usually use both parameters, %fPSA and prostate volume (PSAD), in conjunction with age, tPSA, and other factors, like DRE status. 37,44,45 Those studies consistently demonstrated a significant improvement compared with %fPSA. In the current study, we did not separate nonsuspicious and suspicious DRE results and analyzed ROC curves separately because of the large individual variability of the DRE results and the differences between investigators.…”
Section: Discussionmentioning
confidence: 80%
“…33 A further improvement for better discrimination between PCa and BPH are the so-called artificial neural networks, which usually use both parameters, %fPSA and prostate volume (PSAD), in conjunction with age, tPSA, and other factors, like DRE status. 37,44,45 Those studies consistently demonstrated a significant improvement compared with %fPSA. In the current study, we did not separate nonsuspicious and suspicious DRE results and analyzed ROC curves separately because of the large individual variability of the DRE results and the differences between investigators.…”
Section: Discussionmentioning
confidence: 80%
“…Another possible detection bias results from the fact that multiple studies, including the current, found that obese men have larger prostates (23,24,27). Prostatic enlargement would make detection of an existent cancer less likely, given an equal-sized tumor and an equal number of biopsy cores were obtained (32,33). Combining lower PSA concentrations and prostatic enlargement would represent an inherent bias against detecting cancers among obese men.…”
Section: Discussionmentioning
confidence: 89%
“…The artificial neural network used was a multilayer perceptron with Bayesian regularization (BR-MLP). 15 Preprocessed values of total PSA, the proportion of free PSA, prostate volume, DRE and age were used as input variables. Various models with 2-5 neurons in one hidden layer and one output neuron, were evaluated.…”
Section: Methodsmentioning
confidence: 99%
“…Combined use of several variables has been shown to reduce the number of false-positive PSA results more efficiently than single use of the proportion of free PSA. [12][13][14][15][16][17][18][19] However, LR or neural network algorithms for prostate cancer detection have not been studied prospectively; i.e., use of algorithm outcomes for making real-life biopsy decisions has not been reported. We simulated a prospective setting by using earlier subjects as training data and later ones for testing of the algorithms.…”
Section: Abstract: Prostate Cancer; Screening; Logistic Regression; mentioning
confidence: 99%
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