Predicting the phytotoxic mechanism of action of LiCoO₂ nanomaterials using a novel multiplexed algal cytological imaging (MACI) assay and machine learning

Abstract

Currently, there is a lack of knowledge of how complex metal oxide nanomaterials, like LiCoO2 (LCO) nanosheets, interact with eukaryotic green algae. Previously, LCO was reported to cause a number...

Features of the microalga Raphidocelis subcapitata: physiology and applications

“…As example of toxics whose MoA has been clarified using the microalga R. subcapitata , the following can be mentioned: (1) the antibiotics azithromycin (Almeida et al 2021 ), clarithromycin (Peng et al 2021 ), and erythromycin (Mo et al 2023 ); (2) the herbicides MET (Machado and Soares 2021b ) and diflufenican (Gómez-Martínez et al 2023 ); (3) the heavy metals Cd, Cr, Cu, and Zn (Machado et al 2015 ; Reis et al 2021 ); (4) the antibacterial triclosan (Machado and Soares 2021a ; Mo et al 2022 ) and disinfection by-products (derived of haloacetic acids and halophenols) (Ciccia et al 2023 ; Li et al 2023 ); and (5) nanomaterials, such as metal(loid) oxide nanoparticles Al 2 O 3 , CuO, Mn 3 O 4 , NiO, SiO 2 , and SnO 2 (Sousa et al 2018 , 2019 ), lithiated cobalt oxide nanosheets (Ostovich et al 2023 , 2024 ), micro/nano-plastics (polystyrene) (Reynolds et al 2021 ), and carbon dots (McKeel et al 2024 ).…”