“…Increased subchondral bone and hyaline cartilage regeneration compared to the control sample (over 12 weeks) (Hong et al, 2008), collagen or gelatin (Dorsey et al, 2015;Sim et al, 2015), heparin (Alexander et al, 2013), hyaluronic acid (Wang et al, 2010), poly (ethylene glycol) (PEG) (Ossipov et al, 2008), chondroitin sulfate (Lin et al, 2015), and polyvinyl alcohol (PVA) (Jin et al, 2010a). Depending on the production method, injectable hydrogels can be classified into several categories: Photocrosslinked hydrogels (Tan and Marra, 2010), enzyme-linked hydrogels (Li et al, 2012), Michael addition-mediated hydrogels (Shinde et al, 2013), Schiff-based crosslinked hydrogels (Chiu et al, 2009), click chemistry-mediated hydrogels, Gong et al (2009), pH-sensitive hydrogels (Choi et al, 2011), ion-sensitive hydrogels, Yeon et al (2013) temperature-sensitive hydrogels (Sideris et al, 2016;Mealy et al, 2018), and hydrogel microparticles (HMPs) or HMP microgels (Sivashanmugam et al, 2015) with the following unique properties; Their small size (can be administered through catheters and small needles), significant porosity, and modular nature make them suitable for biomedical applications (Table 1) (Sivashanmugam et al, 2015).…”