Predicting the quality of life in Hong Kong Chinese adults with epilepsy

Au, Alma; Li, Patrick; Chan, John; Lui, Colin H.T.; Ng, Philip K.K.; Kwok, Amy; Leung, P. C.

doi:10.1016/s1525-5050(02)00034-3

Cited by 32 publications

(20 citation statements)

References 21 publications

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“…a to have a negative association in all studies, with HRQoL in 21 of these 26 studies. This finding was not supported by another five studies, although these were mainly small and lacked statistical power (Suurmeijer et al, 2001;Au et al, 2002;Boylan et al, 2004;Meldolesi et al, 2006;Pais-Ribeiro et al, 2007). A number of studies showed that an improvement of HRQoL was monotonic across a seizure reduction and not limited to a state of complete seizure freedom (e.g., Buck et al, 1999;Liou et al, 2005;McLaughlin et al, 2010).…”

Section: (B) Condition Statusmentioning

confidence: 96%

Predictors of health-related quality of life and costs in adults with epilepsy: A systematic review

et al. 2011

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SUMMARYPurpose: Given the high burden of epilepsy on both health-related quality of life (HRQoL) and costs, identification of factors that are predictive of either reduced HRQoL or increased expenditure is central to the better future targeting and optimization of existing and emerging interventions and management strategies for epilepsy. Methods: Searches of Medline, Embase, and Cochrane Library (up to July 2010) to identify studies examining the association between demographic, psychosocial, and condition-related factors and HRQoL, resource utilization or costs in adults with epilepsy. For each study, predictor factor associations were summarized on the basis of statistical significance and direction; the results were then combined across studies. Key Findings: Ninety-three HRQoL and 16 resource utilization/cost studies were included. Increases in seizure frequency, seizure severity, level of depression, and level of anxiety and presence of comorbidity were strongly associated with reduced HRQoL. The majority of studies were cross-sectional in design and had an overall methodologic quality that was judged to be ''moderate'' for HRQoL studies and ''poor'' for health care resource or costs studies. In the 53 multivariate studies, age, gender, marital status, type of seizure, age at diagnosis, and duration of epilepsy did not appear to be associated with HRQoL, whereas the predictive influence of educational and employment status, number of antiepileptic drugs (AEDs) and AED side effects was unclear. The association between predictive factors and HRQoL appeared to be consistent across individuals whether refractory or seizures controlled or managed by AEDs. There were insufficient multivariate studies (five) to reliably comment on the predictors of resource utilization or cost in epilepsy. Significance: In addition to seizure control, effective epilepsy management requires the early detection of those most at risk of psychological dysfunction and comorbidity, and the targeting of appropriate interventions. There is need for more rigorous studies with appropriate multivariate statistical methods that prospectively investigate the predictors of HRQoL, resource utilization, and costs in epilepsy.

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Section: (B) Condition Statusmentioning

confidence: 96%

Predictors of health-related quality of life and costs in adults with epilepsy: A systematic review

et al. 2011

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“…The scale consists of three independent subscales: the "internal health locus of control," "chanceexternal locus of control" or "powerful others-external locus of control" subscales. The scale was translated into Chinese with acceptable internal consistency [22]. The Chinese Ways of Coping Questionnaire (CWCQ) [23] was used to assess coping style.…”

Section: Association Factorsmentioning

confidence: 99%

Risk factors for chronic post-traumatic stress disorder (PTSD) in SARS survivors

Mak

Chu

Pan

et al. 2010

General Hospital Psychiatry

234

205

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The study of PTSD at 30 months post-SARS showed that the predictive value of acute medical variables may fade out. Our findings do not support some prior hypotheses that the use of high dose corticosteroids is protective against the development of PTSD. On the contrary, the adversity both before and after the SARS outbreak may be more important in hindering recovery from PTSD. The risk factor analysis can not only improve the detection of hidden psychiatric complications but also provide insight for the possible model of care delivery for the SARS survivors. With the complex interaction of the biopsychosocial challenges of SARS, an integrated multidisciplinary clinic setting may be a superior approach in the long-term management of complicated PTSD cases.

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“…Threatening elements in epilepsy, such as the ambiguous nature of the disease, recurrence of seizures, and the fear of social exclusion, may cause patients to experience a number of psychosocial problems [7,8]. Recurrent seizures may produce barriers to education, business life, marriage, and social relations [9].…”

Section: Introductionmentioning

confidence: 99%