Predicting the Risk of Bowel-Related Quality-of-Life Impairment After Restorative Resection for Rectal Cancer

Battersby, Nick; Juul, Therese; Christensen, Peter; Janjua, A. Z.; Branagan, Graham; Emmertsen, Katrine Jøssing; Norton, Christine; Hughes, Robert J.; Laurberg, Søren; Moran, Brendan

doi:10.1097/dcr.0000000000000552

Cited by 163 publications

(120 citation statements)

References 39 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Our results suggest that mesorectal excision is an important factor in the development of LARS. Whilst some studies have suggested that the level of the anastomosis does not influence functional outcome after resection for rectal cancer [14], there is evidence to suggest [15][16][17][18] that impaired function after rectal resection is related to reduced neorectal compliance that occurs in association with lower anastomoses.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with low anterior resection syndrome after surgical treatment of rectal cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Factors associated with low anterior resection syndrome after surgical treatment of rectal cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In addition, there are clearly differences based on gender [2, 4]. Specifically, RC survivors with anastomosis experience variable degrees of bowel function (BF) changes after their cancer treatment(s) [5, 6]. Loss of bowel control is universal for people with ostomies, although some are able to attain a certain measure of control utilizing irrigation techniques [7], and ostomy pouching systems can help manage this loss of bowel control.…”

Section: Introductionmentioning

confidence: 99%

Physical activity, bowel function, and quality of life among rectal cancer survivors

et al. 2017

View full text Add to dashboard Cite

Purpose Physical activity (PA) is positively associated with numerous health benefits among cancer survivors. This study examined insufficiently-investigated relationships among PA, health-related quality of life (HRQOL), and bowel function (BF) in rectal cancer survivors. Methods RC survivors (n=1,063) ≥five years from diagnosis in two Kaiser Permanente Regions were mailed a multidimensional survey to assess HRQOL and BF. PA was assessed by a modified Godin-Leisure Time Exercise Questionnaire. PA minutes were categorized into weighted categories based on guidelines: 1) not active (zero PA minutes); 2) insufficiently active (1–149 PA minutes); 3) meeting guidelines (150–299 PA minutes); and 4) above guidelines (≥ 300 PA minutes). Relationships of PA with HRQOL and BF were evaluated using multiple linear regression, stratified by sex and ostomy status for BF. Types of PA identified as helpful for BF and symptoms addressed were summarized. Results Response rate was 60.5%. Of 557 participants, 40% met or exceeded PA guidelines, 34% were Not Active, and 26% were Insufficiently Active. Aerobic activities, specifically walking and cycling, were most commonly reported to help BF. Higher PA was associated with better psychological wellbeing and multiple SF12 scales, worse BF scores in men with ostomies, and better BF scores in women. Conclusions Meeting or exceeding PA guidelines was associated with higher HRQOL. Although the BF findings are exploratory, they suggest women may benefit from increased PA, whereas men with ostomies may face challenges that require more study. Identifying PA strategies that will lead to improved patient compliance and benefit are needed.

show abstract

“…In addition to socioeconomic considerations, we need to determine if there is still an advantage in the use of preoperative radio(chemo)therapy (PRT/PCRT) or if further improvement in survival outcomes can be obtained, since the greatest benefit of PRT/PCRT is local recurrence control based on results of well‐known random control trials (RCTs; SRCT, TME, FFCD9201, EORTC22912 and TROG 01.04 trials) irrespective of the patterns or combinations of radiotherapy and chemotherapy. In addition, potentially adverse postoperative effects and quality of life outcomes should be taken into consideration when comprehensively evaluating the role of PRT/PCRT …”

mentioning

confidence: 99%

“…In addition, potentially adverse postoperative effects and quality of life outcomes should be taken into consideration when comprehensively evaluating the role of PRT/ PCRT. [11][12][13][14][15] Therefore, in this systematic review and meta-analysis we have summarized and re-evaluated the role of PRT/PCRT and also examined current neoadjuvant regimens for effectiveness in treating localized rectal cancer patients. Our goal was to determine what benefits PRT/PCRT has brought to localized rectal cancer patients in terms of perioperative and long-term outcomes.…”

mentioning

confidence: 99%

What has preoperative radio(chemo)therapy brought to localized rectal cancer patients in terms of perioperative and long‐term outcomes over the past decades? A systematic review and meta‐analysis based on 41,121 patients

Gao

Wang

et al. 2017

Intl Journal of Cancer

106

View full text Add to dashboard Cite

We asked what preoperative radiotherapy/chemoradiotherapy (PRT/PCRT) has brought to patients in terms of perioperative and long-term outcomes over the past decades. A systematic review and meta-analysis was conducted using PubMed, Embase and Web of Science databases. All original comparative studies published in English that were related to PRT/PCRT and surgical resection and which analyzed survival, postoperative and quality of life outcomes were included. Data synthesis and statistical analysis were carried out using Stata software. Data from 106 comparative studies based on 80 different trials enrolling 41,121 patients were included in our study. Based on our overall analyses, PRT/PCRT significantly improved patients' local recurrence-free survival (LRFS), but neither overall survival (OS) nor metastasis-free survival (MFS) showed improvement. In addition, PRT significantly increased the postoperative morbidity and mortality but PCRT did not have a significant effect. Furthermore, PRT/PCRT significantly increased the risk of postoperative wound complications but not anastomotic leakage and bowel obstruction. Our comprehensive subgroup analyses further supported the aforementioned results. Meanwhile, long-term anorectal symptoms (impaired squeeze pressures, use of pads, incontinence and urgency) and erectile dysfunction were also significantly increased in patients after PRT/PCRT. The benefits of PRT/PCRT as applied over the last several decades have not been sufficient to improve OS. Metastases of primary tumor and postoperative adverse effects were the two primary obstacles for an improved OS. In fact, the greatest advantage of PRT/PCRT is still local tumor control and a significantly improved LRFS.

show abstract

Predicting the Risk of Bowel-Related Quality-of-Life Impairment After Restorative Resection for Rectal Cancer

Cited by 163 publications

References 39 publications

Factors associated with low anterior resection syndrome after surgical treatment of rectal cancer

Factors associated with low anterior resection syndrome after surgical treatment of rectal cancer

Physical activity, bowel function, and quality of life among rectal cancer survivors

What has preoperative radio(chemo)therapy brought to localized rectal cancer patients in terms of perioperative and long‐term outcomes over the past decades? A systematic review and meta‐analysis based on 41,121 patients

Contact Info

Product

Resources

About