The COVID-19 epidemic, which turned into a pandemic, has led to the introduction of lockdown in many countries as a measure to prevent the spread of the virus. Significant changes have occurred in the lives of Russian students. The research objective is to study students’ strategies of adaptation to the self-isolation caused by the need to prevent the spread of COVID-19. To achieve this purpose, an online survey of students was conducted, followed by a correlation analysis of the data. The survey involved 269 students aged 17-21. In self-isolating conditions, students prefer to use strategies aimed at self-change. Two groups of strategies are distinguished in the structure of students’ adaptive behavior, between which there are positive correlations of average strength. The first group includes students’ preferable behavior strategies (accommodating, self-change, and self-immersion). The second group consists of strategies that are not popular among students (environment changing, waiting, avoidance, and passive self-representation). Male students are more active in solving problems than female students. The research results expand the existing understanding of students’ reactions to changes related to self-isolation. They can be useful to teachers, psychologists involved in assessing the social consequences of the COVID-19 pandemic on students.