Prediction and characterization of drug release in a multi-drug release system

Im, Ji Sun; Lee, Sung Kyu; Bai, Byong Chol; Lee, Young-Seak

doi:10.1016/j.jiec.2011.11.101

Cited by 17 publications

(6 citation statements)

References 35 publications

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“…Im et al used alginate and chitosan to coat the lactobacillus-incorporated polyvinyl alcohol-based electrospun fibers. This formulation was designed to release lactobacillus in the large intestine after chitosan and alginate were dissolved in the acidic and then neutral environments of the GIT [104].…”

Section: Methods Of Incorporating Drugsmentioning

confidence: 99%

Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery

et al. 2018

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The electrospinning process has gained popularity due to its ease of use, simplicity and diverse applications. The properties of electrospun fibers can be controlled by modifying either process variables (e.g., applied voltage, solution flow rate, and distance between charged capillary and collector) or polymeric solution properties (e.g., concentration, molecular weight, viscosity, surface tension, solvent volatility, conductivity, and surface charge density). However, many variables affecting electrospinning are interdependent. An optimized electrospinning process is one in which these parameters remain constant and continuously produce nanofibers consistent in physicochemical properties. In addition, nozzle configurations, such as single nozzle, coaxial, multi-jet electrospinning, have an impact on the fiber characteristics. The polymeric solution could be aqueous, a polymeric melt or an emulsion, which in turn leads to different types of nanofiber formation. Nanofiber properties can also be modified by polarity inversion and by varying the collector design. The active moiety is incorporated into polymeric fibers by blending, surface modification or emulsion formation. The nanofibers can be further modified to deliver multiple drugs, and multilayer polymer coating allows sustained release of the incorporated active moiety. Electrospun nanofibers prepared from polymers are used to deliver antibiotic and anticancer agents, DNA, RNA, proteins and growth factors. This review provides a compilation of studies involving the use of electrospun fibers in biomedical applications with emphasis on nanoparticle-impregnated nanofibers.

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Section: Methods Of Incorporating Drugsmentioning

confidence: 99%

Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery

et al. 2018

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“…Figure 2 shows the suggested mechanism of drug release of the prepared multilayer-coated nanofibers. 84 In addition to these investigated modifications of nanofiber processing, modulations in the electrospinning setup were also tested by researchers. Two-stream electrospinning was employed to make composite nanofibrous meshes from different polymers/drugs.…”

Section: Other Approaches In Electrospinningmentioning

confidence: 99%

“…Figure 6 shows a schematic illustration of the inhibitory action of CAP nanofibers containing the antiviral drugs. 120 Besides the commonly known implantable nanofibrous drug-delivery systems, few studies 84,123 have been published on the application of drug-loaded nanofibers as oral drug-delivery systems, which is the preferred route of drug administration from the aspects of convenience, patient compliance, and cost-effectiveness. Eudragit L 100-55 nanofibers containing diclofenac sodium, a nonsteroidal anti-inflammatory drug, were fabricated for oral drug-delivery purposes.…”

Section: Most Innovative Applicationsmentioning

confidence: 99%

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

204

104

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Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.

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“…The transdermal drug delivery system delivers the drugs locally or systemically via the skin. This is suitable for drugs that cannot be taken by the oral route [4]. Taepaiboon et al have loaded vitamin E and vitamin A in cellulose acetate polymer-based electrospun fibers [5].…”

Section: Vitaminsmentioning

confidence: 99%