Due to its many engineering applications, low manufacturing costs, and environmental friendliness, 3D printing is considered one of the most promising manufacturing technologies. The quality of printed parts will inevitably be affected by the controllable variables used in the 3D printing process. The present study aims to investigate how different printing process parameters affect the bending strength of PLA prints. The ASTM D790 standard was used to fabricate the samples in this work, while the Taguchi principle was used to design the experiments. The following values were chosen: shell width (0.8, 1.2, 1.6, and 2 mm), layer thickness (0.15, 0.2, 0.25, and 0.3 mm), and infill density (40%, 60%, 80%, and 100%). The results showed that fill density is the most effective variable for improving bending strength. Measurements of infill density (100%), layer thickness (0.15 mm), and shell width (2 mm) gave the best results, which were calculated to be 83.1479 MPa in bending test. The mathematical model in this study was developed using linear regression analysis, and the residuals confirmed that the model fit the data well, with a maximum error of 6.1%.