Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years

Grabenhenrich, Linus; Keil, Thomas; Reich, Andreas; Gough, Hannah; Beschorner, John; Hoffmann, Ute; Bauer, Carl‐Peter; Förster, Johannes; Schuster, Antje; Schramm, Dirk; Nitsche, Oliver; Zepp, Fred; Lee, Youngae; Bergmann, Renate L.; Bergmann, K. C.; Wahn, Ulrich; Lau, Susanne

doi:10.1016/j.jaci.2015.03.040

Cited by 61 publications

(65 citation statements)

References 36 publications

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“…Analogous to previous studies, lower IgE levels were found among participants with more siblings [2,19]. While a hereditary component was clearly confirmed in our cohort [20,21,22], allergies of fathers, but not mothers, seemed to be the major confounding factor for IgE development in their offspring. Previous studies suggested that predominately maternal conditions play an important role in IgE production and asthma development in the offspring [23,24].…”

Section: Discussionsupporting

confidence: 88%

Influence of Intrinsic and Lifestyle Factors on the Development of IgE Sensitization

Stemeseder¹,

Klinglmayr²,

Moser³

et al. 2017

Int Arch Allergy Immunol

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Background: IgE sensitization is a prerequisite for the development of allergic symptoms. The investigation of factors influencing the development of IgE is therefore crucial for understanding the onset of allergic diseases. Methods: This epidemiological study investigated personal, intrinsic, and lifestyle factors in a nonselected cohort of 501 Austrian adolescents (aged 12-21 years). IgE levels to 112 allergen molecules were analyzed in the serum of participants using the ImmunoCAP ISAC®. Allergic sensitization, IgE levels to single allergens, and ISAC score sums were correlated with results obtained from a questionnaire. Results: In this adolescent cohort, male participants showed a higher sensitization frequency (56.8%) compared to females (50.9%) and significantly increased IgE levels to profilins. Underweight subjects demonstrated a stronger IgE sensitization. Family size inversely correlated with IgE levels to PR-10 allergens, and predominately paternal allergies were a predictive factor for IgE sensitization in the children. Vaccination, breastfeeding, and delivery mode showed no influence, while a highly protective effect was observed for growing up on a farm. Of all of the investigated lifestyle factors, only smoking significantly influenced the risk for IgE development. Participants with moderate frequencies of colds showed increased sensitization levels. Conclusion: A hereditary predisposition and lifestyle factors such as a farming environment, smoking, family size, body weight, or frequency of colds significantly influenced the development of allergen-specific IgE in this cohort of adolescents.

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Section: Discussionsupporting

confidence: 88%

Influence of Intrinsic and Lifestyle Factors on the Development of IgE Sensitization

Stemeseder¹,

Klinglmayr²,

Moser³

et al. 2017

Int Arch Allergy Immunol

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“…Our finding that males with early life FA had an increased risk of FA at 16 years, compared to females extends the findings from other birth cohorts with follow-up through school-age [26], and parallels findings in which other allergic diseases were considered [34, 35]. Yet, females from adolescence onward are much more likely to experience severe reactions, including anaphylaxis, compared to similar-aged men, an observation which has been attributed to estrogen playing a role in the susceptibility to anaphylaxis [36].…”

Section: Discussionsupporting

confidence: 87%

Food-Related Symptoms and Food Allergy in Swedish Children from Early Life to Adolescence

et al. 2016

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BackgroundRisk factors for persistence of food-related symptoms (FRS) and food allergy (FA) from early life to adolescence are incompletely understood. The aim of this study was to identify risk factors for FRS and FA in adolescence amongst children with FRS or FA in the first four years of life (early life).MethodsIn children enrolled in a Swedish birth cohort and followed to 16 years (n = 2572), we defined children with early life FRS in the absence of FA, and FA. Corresponding phenotypes were defined at 16 years. Associations between potential risk factors at 4 years and FRS and FA at 16 years were investigated using logistic regression.ResultsEarly life FRS and FA prevalences were 12.2% and 6.8%, respectively. Amongst children with early life FRS, 35.7% had FRS or FA at 16 years, whereas 74.3% of the children with early life FA had FA at 16 years. For each of the early life phenotypes, parental allergy, early life allergic multimorbidity, early life reactions to peanuts/tree nuts and IgE reactivity at 4 years were statistically significantly associated with FRS or FA at 16 years. In contrast, male sex was associated with an increased risk of FA at 16 years among children with early life FA only.ConclusionsIn early life, food-related symptoms are twice as common as food allergy. Unlike food allergy, food-related symptoms often remit by adolescence. Yet, these phenotypes have many common risk factors for persistence to adolescence.

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“…Data from large prospective birth cohorts also show that the highest prevalences of allergic asthma, atopic dermatitis, and food allergy have already been reached by this age, and that an additional increase is seen only for allergic rhinitis in the second decade of life [10, 11]. …”

Section: Discussionmentioning

confidence: 99%

Allergy and school: nothing to be sneezed at!

et al. 2016

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Background:Allergic diseases account for the largest proportion of chronic diseases in childhood and adolescence and place a significant burden on everyday family, social, and in particular school life. Without appropriate education, affected individuals often have little of the knowledge required to understand and deal safely with their allergic disease, and their social environment (school) generally offers insufficient information. An interdisciplinary project involving the Bielefeld Community Foundation (“Bielefelder Bürgerstiftung”), the Children’s Center Bethel, and the local school authority investigated the current knowledge, possibilities for increasing that knowledge, as well as pupils’ and teachers’ perception of the problems experienced by fellow pupils, while at the same time collecting current prevalence figures on allergic diseases among primary school children.Methods:All Bielefeld primary schools were invited to participate in the 3 years between 2008 and 2010. A teaching session on allergic diseases held by specialists from the pediatric hospital formed the core of the project. A standardized survey of children – which also addressed non-affected children for the first time in Germany – on the effects of, their knowledge of, and their attitudes toward allergic diseases, as well as an assessment of their quality of life (cross-sectional study), was conducted prior to and following each session. Parents were also surveyed.Results:In all, 24 schools per year, each with around 60 classes and 1,250 pupils aged 9 years, took part between 2008 and 2010. Approximately 30 % reported suffering from an allergic disease themselves, of which – with regard to single entries – 16 % were “allergies,” 4 % “asthma,” and 5 % atopic dermatitis. Figures collected from parents were only slightly lower than those from their children. Clear deficits that existed in terms of factual knowledge and/or correct conduct in allergic disease – among affected children as well as in their social environment – prior to the education program were noticeably improved by the teaching session.Discussion:The prevalence data gathered here confirm the high numbers recently found in the KiGGS study. Thus, allergic diseases represent a considerable disease risk and potential burden in school children. Providing affected children and their social environment (teachers, fellow pupils) with specialist education can bring about considerable improvements in everyday school life.

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Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years

Cited by 61 publications

References 36 publications

Influence of Intrinsic and Lifestyle Factors on the Development of IgE Sensitization

Influence of Intrinsic and Lifestyle Factors on the Development of IgE Sensitization

Food-Related Symptoms and Food Allergy in Swedish Children from Early Life to Adolescence

Allergy and school: nothing to be sneezed at!

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