Prediction and treatment of asthma in preschool children at risk: study design and baseline data of a prospective cohort study in general practice (ARCADE)

Wonderen, Karina E. van; Mark, Lonneke B van der; Mohrs, Jacob; Geskus, Ronald B.; Wal, Willem M. van der; Aalderen, W. M. C. van; Bindels, Patrick J E; Riet, Gerben ter

doi:10.1186/1471-2466-9-13

Cited by 13 publications

(22 citation statements)

References 53 publications

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“…Prevalence estimates and prediction models' performances using different definitions To assess the variation in prevalence and prediction model performance we used data from the ARCADE (Airway Complaints and Asthma Development) study, an ongoing prospective cohort study [10]. One of the aims of ARCADE is to construct a primary care-based asthma prediction model for pre-school children at risk of developing asthma.…”

Section: Definitions and Operationalisations Of Asthmamentioning

confidence: 99%

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Different definitions in childhood asthma: how dependable is the dependent variable?

Wonderen¹,

Mark²,

Mohrs³

et al. 2009

Eur Respir J

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There is abundant literature on how to select and statistically deal with predictors in prediction models. Less attention has been paid to the choice of the outcome. We assessed the impact of different asthma definitions on prevalence estimates and on the prediction model's performances.We searched PubMed and extracted data of definitions used to diagnose childhood asthma (between 6 and 18 yrs) in cohort studies. Next, using data from an ongoing cohort study (n5186), we constructed and compared four prediction models which all predict asthma at age 6 yrs, using a fixed set of predictors and four different definitions in turn. We defined an area of clinical indecision (posterior probability between 25% and 60%) and calculated the number of children who remained inside this area.122 papers yielded 60 different definitions. Prevalence estimates varied between 15.1% and 51.1% depending on the asthma definition used. The percentage of children whose posterior asthma probability was in the area of clinical indecision varied from 14.9% to 65.3%.Variation in definitions and its effect on the performance of prediction models may be another source of otherwise inexplicable variation in daily clinical decision making. More uniformity of operational asthma definitions seems needed.

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Section: Definitions and Operationalisations Of Asthmamentioning

confidence: 99%

“…Predictors were: 1) wheezing (during the previous year, but apart from colds); 2) eczema (during the previous year); and 3) specific immunoglobulin (Ig)E directed against house dust mite, cat or dog dander [12,15]. Information on the predictors was collected at time of enrolment (in the ARCADE study) [10].…”

Section: Development Of Different Prediction Modelsmentioning

confidence: 99%

Different definitions in childhood asthma: how dependable is the dependent variable?

Wonderen¹,

Mark²,

Mohrs³

et al. 2009

Eur Respir J

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“…ARCADE participants were recruited from 14 general practices in 2004, in The Netherlands. Admission criteria and baseline characteristics have been published elsewhere [4]. Briefly, children were between 1 and 5 years old had a high risk of developing asthma.…”

Section: Methodsmentioning

confidence: 99%

“…Every 12 months (T0 and T12) they received a questionnaire containing 130 multiple-choice questions about quality of life and airway problems [4]. In between (T6 and T18) they received a shorter questionnaire, containing 38 multiple-choice questions about the child’s health-related quality of life only.…”

Section: Methodsmentioning

confidence: 99%

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The effect of two lottery-style incentives on response rates to postal questionnaires in a prospective cohort study in preschool children at high risk of asthma: a randomized trial

Mark

Wonderen

Mohrs

et al. 2012

BMC Med Res Methodol

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BackgroundIn research with long-term follow-up and repeated measurements, quick and complete response to questionnaires helps ensure a study’s validity, precision and efficiency. Evidence on the effect of non-monetary incentives on response rates in observational longitudinal research is scarce.ObjectivesTo study the impact of two strategies to enhance completeness and efficiency in observational cohort studies with follow-up durations of around 2 years.Method and interventionIn a factorial design, 771 children between 2 and 5 years old and their parents participating in a prospective cohort study were randomized to three intervention groups and a control group. Three types of lotteries were run: (i) daytrip tickets for the whole family to a popular amusement park if they returned all postal questionnaires, (ii) €12.50-worth gift vouchers for sending back the questionnaire on time after each questionnaire round and (iii) a combination of (i) and (ii).Main outcome measuresPrimary outcome was the proportion of participants who returned all questionnaires without any reminder. Secondary outcomes were ‘100% returned with or without reminder’, ‘probability of 100% non-response’, ‘probability of withdrawal’, ‘proportion of returned questionnaires’ and ‘overall number of reminders sent’.Statistical analysisAfter testing for interaction between the two lottery interventions, the two trials were analysed separately. We calculated risk differences (RD) and numbers needed to “treat” and their 95% confidence intervals.ResultsDaytrip nor voucher intervention had an effect on the proportion of participants who returned all questionnaires (RD −0.01; 95% CI-0.07 – 0.06) and (RD 0.02; 95% CI-0.50 – 0.08), respectively. No effects were found on the secondary outcomes.ConclusionOur findings do not support the idea that lottery-style incentives lead to more complete response to postal questionnaires in observational cohort studies with repeated data collection and follow-up durations of around 2 years.

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Astma bij kinderen voorspellen met de CAPS

2015

Prakt. Huisartsgen.

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Prediction and treatment of asthma in preschool children at risk: study design and baseline data of a prospective cohort study in general practice (ARCADE)

Cited by 13 publications

References 53 publications

Different definitions in childhood asthma: how dependable is the dependent variable?

Different definitions in childhood asthma: how dependable is the dependent variable?

The effect of two lottery-style incentives on response rates to postal questionnaires in a prospective cohort study in preschool children at high risk of asthma: a randomized trial

Astma bij kinderen voorspellen met de CAPS

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