Prediction and validation of nonalcoholic fatty liver disease by fatty liver index in a Japanese population

Takahashi, Satoko; Tanaka, Marenao; Higashiura, Yukimura; Mori, Kazuma; Hanawa, Nagisa; Ohnishi, Hirofumi; Furuhashi, Masato

doi:10.1507/endocrj.ej21-0563

Cited by 25 publications

(26 citation statements)

References 58 publications

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“…Third, since the recruited participants were all Japanese, the results obtained in the present study might not be applicable to other races. In this study, FLI ≥35 for men and FLI ≥16 for women were used for detection of fatty liver, as previously reported using 14,471 Japanese individuals (men/women 9,240/5,231; mean age 48 -9 years) 6 . Optimal cut-off values of FLI would be required according to sex and races.…”

Section: Discussionmentioning

confidence: 99%

“…Detection of hepatic steatosis has been recommended to be carried out either by blood biomarkers/scores, imaging techniques or liver histology 4 . In the present study, hepatic steatosis was determined by FLI as a recommended biomarker 4 , and FLI ≥35 for men (area under the curve 0.82; sensitivity 76.7%; specificity 71.3%) and FLI ≥16 for women (area under the curve 0.91; sensitivity 85.2%; specificity 81.4%) were used for detection of fatty liver as previously reported using 14,471 Japanese individuals (men/women 9,240/5,231; mean age 48 ± 9 years) 6 .…”

Section: Methodsmentioning

confidence: 99%

“…FLI was originally reported in Italy as an index for the prediction of fatty liver detected by abdominal ultrasonography, and the cut‐off value was reported to be FLI ≥60 5 . The ability of FLI to predict fatty liver has been verified, and its usefulness has been reported in several countries 5,6 . However, sex and racial differences in FLI level were not taken into consideration in most of the studies.…”

Section: Introductionmentioning

confidence: 99%

“…However, sex and racial differences in FLI level were not taken into consideration in most of the studies. We recently showed that simple and useful cut-off values for prediction of NAFLD in Japanese men and women were FLI ≥35 and FLI ≥16, respectively 6 .…”

Section: Introductionmentioning

confidence: 99%

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Circulating level of fatty acid‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals

Tanaka

Takahashi

Higashiura

et al. 2022

J of Diabetes Invest

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Aims/Introduction Metabolic dysfunction‐associated fatty liver disease (MAFLD), defined as hepatosteatosis with type 2 diabetes mellitus, overweight/obesity or metabolic dysregulation, has been proposed as a new feature of chronic liver disease. Fatty acid‐binding protein 4 (FABP4) is expressed in adipose tissue, and secreted FABP4 is associated with the development of insulin resistance and atherosclerosis. However, the relationship between MAFLD and FABP4 has not been fully addressed. Materials and Methods Associations of MAFLD with metabolic markers, including FABP4, fibroblast growth factor 21 and adiponectin, were investigated in 627 individuals (men/women 292/335) in the Tanno‐Sobetsu Study, a population‐based cohort. Results The mean age was 65 years (range 19–98 years, median [interquartile range] 68 [56–76] years). Hepatosteatosis was determined by the fatty liver index (FLI), and FLI ≥35 for men and FLI ≥16 for women were used for detection of fatty liver, as previously reported using 14,471 Japanese individuals. FLI was positively correlated with systolic blood pressure and levels of FABP4 (r = 0.331, P < 0.001), fibroblast growth factor 21, homeostasis model assessment of insulin resistance as an insulin resistance index and uric acid, and was negatively correlated with levels of high‐density lipoprotein cholesterol and adiponectin. FABP4 concentration was independently associated with FLI after adjustment of age, sex, systolic blood pressure and levels of uric acid, high‐density lipoprotein cholesterol, homeostasis model assessment of insulin resistance, adiponectin and fibroblast growth factor 21 in multivariable regression analysis. Logistic regression analysis showed that FABP4 was an independent predictor of MAFLD after adjustment of age, sex, presence of diabetes mellitus, hypertension and dyslipidemia, and levels of uric acid, homeostasis model assessment of insulin resistance, adiponectin and fibroblast growth factor 21. Conclusions FABP4 concentration is independently associated with FLI and is an independent predictor of MAFLD in middle‐aged and elderly individuals.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circulating level of fatty acid‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals

Tanaka

Takahashi

Higashiura

et al. 2022

J of Diabetes Invest

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“…Fatty liver index (FLI) was calculated, as follows, by using BMI, waist circumference (WC), and levels of γ-glutamyl transpeptidase (GGT) and triglycerides [ 37 ]: FLI = [e (0.953 × ln (triglycerides) + 0.139 × BMI + 0.718 × ln (GGT) + 0.053 × WC − 15.745) ]/[1 + e (0.953 × ln (triglycerides) + 0.139 × BMI + 0.718 × ln (GGT) + 0.053 × WC − 15.745) ] × 100. It has been reported that FLI has high concordance with the histological criteria for NAFLD [ 37 , 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Plasma Tsukushi Concentration Is Associated with High Levels of Insulin and FGF21 and Low Level of Total Cholesterol in a General Population without Medication

et al. 2022

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Tsukushi (TSK) is a member of the small leucine-rich proteoglycan family that controls developmental processes and organogenesis. TSK was also identified as a new hepatokine, which is mainly expressed in the liver, and is secreted by hepatocytes, to regulate energy and glycolipid metabolism in response to nonalcoholic fatty liver disease. However, the role of plasma TSK, especially its role in the general population, has not been fully addressed. We investigated the associations between plasma TSK concentration and several metabolic markers, including fibroblast growth factor 21 (FGF21), a hepatokine, and adiponectin, an adipokine, in 253 subjects (men/women: 114/139) with no medication in the Tanno–Sobetsu Study, which employed a population-based cohort. There was no significant sex difference in plasma TSK concentration, and the level was positively correlated with the fatty liver index (FLI) (r = 0.131, p = 0.038), levels of insulin (r = 0.295, p < 0.001) and levels of FGF21 (r = 0.290, p < 0.001), and was negatively correlated with the total cholesterol level (r = −0.124, p = 0.049). There was no significant correlation between the TSK level and body mass index, waist circumference, adiponectin, high-density lipoprotein cholesterol or total bile acids. The multivariable regression analysis showed that high levels of insulin and FGF21 and a low level of total cholesterol were independent determinants of plasma TSK concentration, after adjustment for age, sex and FLI. In conclusion, plasma TSK concentration is independently associated with high levels of insulin and FGF21, a hepatokine, and a low level of total cholesterol, but not with adiposity and adiponectin, in a general population of subjects who have not taken any medications.

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Fatty liver index (FLI): more than a marker of hepatic steatosis

Kaneva,

Bojko

2023

J Physiol Biochem

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Prediction and validation of nonalcoholic fatty liver disease by fatty liver index in a Japanese population

Cited by 25 publications

References 58 publications

Circulating level of fatty acid‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals

Circulating level of fatty acid‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals

Plasma Tsukushi Concentration Is Associated with High Levels of Insulin and FGF21 and Low Level of Total Cholesterol in a General Population without Medication

Fatty liver index (FLI): more than a marker of hepatic steatosis

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