Prediction Equations Underestimate Resting Energy Expenditure in Patients With End‐Stage Cystic Fibrosis

Hollander, F.M.; Kok, Annemieke; Roos, N.M. de; Meerkerk, Gerdien Belle-van; Graaf, E.A. van de

doi:10.1177/0884533616645819

Cited by 12 publications

(3 citation statements)

References 30 publications

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“…67,68 Predictive equations often underestimate energy needs in both the peri-operative transplant periods with needs ranging from 110% to 200% compared to individuals without CF. 69,70 Energy needs gradually decline after lung transplant due to decreased energy expenditure from reduced pulmonary demands and improved appetite. 67,71 Nutritional status typically improves after transplant, with the most significant weight gains seen in those previously malnourished.…”

Section: Extra-pulmonary Cf Considerationsmentioning

confidence: 99%

“…74,75 Given fluctuating energy needs, ongoing consultation by a CF dietitian is recommended to avoid malnutrition and obesity. 69,[76][77][78] The development of hypervitaminosis A and E has been observed in CF and non-CFLTRs; thus, the routine continuation of CF-specific combination vitamins after transplant is not recommended. [79][80][81] Instead, monitoring fat soluble vitamin levels starting at 3 months after transplant and repleting individual deficiencies as needed is recommended.…”

Section: Extra-pulmonary Cf Considerationsmentioning

confidence: 99%

See 1 more Smart Citation

Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients

Shah¹,

Lowery²,

Chaparro³

et al. 2021

The Journal of Heart and Lung Transplantation

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Section: Extra-pulmonary Cf Considerationsmentioning

confidence: 99%

Section: Extra-pulmonary Cf Considerationsmentioning

confidence: 99%

Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients

Shah¹,

Lowery²,

Chaparro³

et al. 2021

The Journal of Heart and Lung Transplantation

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“…In previous clinical studies and current practice, REE is commonly estimated by using prediction equations and is underestimated in CF patients especially before LTx. 33,[49][50][51] However, this has not been studied after LTx. In our unique longitudinal study, we investigated the change in REE in CF patients before and after LTx with a follow-up of 2 years.…”

Section: Clinical Evidence and Future Prospects In Nutritional Therapy In Cystic Fibrosismentioning

confidence: 99%

Nutritional challenges in adult patients with cystic fibrosis pre and post lung transplantation

Hollander-Kraaijeveld¹

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Cystic fibrosis (CF) is one of the most common fatal hereditary disorders worldwide. 1 It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This gene codes for the CFTR protein, which functions as a channel for chloride ions and water across the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes. A mutation in this CFTR gene impairs the function of these channels, which leads to thicker and sticky mucus. Because the CFTR protein is present in all mucus producing organs in the body, CF is a multi-system genetic disorder affecting the lungs, pancreas, liver, intestine and other organs. 2,3 Symptoms of CF can differ due to the many different mutations in the CFTR gene, ranging from complete absence or mild dysfunction of CFTR. Depending on the impaired function of CFTR, patients may experience fat malabsorption and chronic pulmonary infections leading to bronchiectasis and progressive lung damage. 4 Therapy is directed to maintain and optimize pulmonary function and nutritional status, since these are key factors in survival. 5 Recent decades have shown a great improvement in survival of individuals with CF. 6 Registries in Europe, the USA, and Canada now demonstrate that median survival for CF is around 40-50 years. 7 This is much higher than the median age at death worldwide, which is only around 30 years 6,7 due to health inequalities and a dramatic variation in survival of CF individuals across Europe. 6,8 The increased survival in some Western countries can be explained by newborn screening programs, 9,10 centralized care 9 using evidence-based clinical and nutrition guidelines, 11 access to CF specific medications, and the introduction of drugs that modulate CFTR. 12,13 As the majority of children with CF now live into adulthood, the number of adults with CF is growing. This also means that more CF patients have different stages of pulmonary disease, with complex co-morbidity. Therefore, health care professionals need to be able to adapt the nutritional treatment of a CF patient across the life span. NUTRITIONAL CARENutritional status has a positive association with pulmonary function and survival in CF. 14 However, many patients suffer from an impaired nutritional status, due to a combination of increased nutrient demands, increased losses, and impaired nutritional intake. Insufficient nutritional intake is common in the CF population. There are many different reasons for this.First, CF patients often experience severe fatigue 15 which can contribute to a reduced food General introduction 20.

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New equation to estimate resting energy expenditure in non-critically ill patients

Barcellos

Borges

Torres

2020

Clinical Nutrition ESPEN

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Prediction Equations Underestimate Resting Energy Expenditure in Patients With End‐Stage Cystic Fibrosis

Abstract: Prediction equations underestimate REE in patients with end-stage CF. REE per kg of FFM is lower post-LTx than pre-LTx in patients with CF. Measurement of REE is recommended for patients with CF, especially pre-LTx, to optimize energy requirements for improving nutrition status.

Cited by 12 publications

References 30 publications

Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients

Cystic fibrosis foundation consensus statements for the care of cystic fibrosis lung transplant recipients

Nutritional challenges in adult patients with cystic fibrosis pre and post lung transplantation

New equation to estimate resting energy expenditure in non-critically ill patients

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