Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer

Wermker, Kai; Belok, Friederike; Schipmann, Stephanie; Klein, Martin; Schulze, Hans‐Joachim; Hallermann, Christian

doi:10.1016/j.jcms.2015.02.002

Cited by 41 publications

(21 citation statements)

References 46 publications

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“…LSCC is a common malignant tumor of the head and neck that accounts for about 30% of oral cancers . The rate of cervical metastasis from SCC of the lip reportedly ranges from 4% to 15% . However, there is insufficient information for predicting the OS and CSS in patients with LSCC .…”

Section: Discussionmentioning

confidence: 99%

“…2 The rate of cervical metastasis from SCC of the lip reportedly ranges from 4% to 15%. [16][17][18] However, there is insufficient information for predicting the OS and CSS in patients with LSCC. 19 Although the AJCC staging system has significant predictive power for the prognosis of LSCC patients, it does not include some important risk factors such as sex, 20 The proposed nomograms are easy-to-use clinical tools that will facilitate the promotion of patient counseling and personalized treatments.…”

Section: Discussionmentioning

confidence: 99%

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Nomograms for predicting long‐term overall survival and cancer‐specific survival in lip squamous cell carcinoma: A population‐based study

Pan

Yang

et al. 2019

Cancer Medicine

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Background The goal of this study was to establish and validate two nomograms for predicting the long‐term overall survival (OS) and cancer‐specific survival (CSS) in lip squamous cell carcinoma (LSCC). Methods This study selected 4175 patients who were diagnosed with LSCC between 2004 and 2015 in the SEER (Surveillance, Epidemiology, and End Results) database. The patients were allocated randomly to a training cohort and validation cohort. Variables were selected using a backward stepwise method in a Cox regression model. Based on the predictive model with the identified prognostic factors, nomograms were established to predict the 3‐, 5‐, and 8‐year survival OS and CSS rates of LSCC patients. The accuracy of the nomograms was evaluated based on the consistency index (C‐index), while their prediction accuracy was evaluated using calibration plots. Decision curve analyses (DCAs) were used to evaluate the performance of our survival model. Results The multivariate analyses demonstrated that age at diagnosis, marital status, sex, race, American Joint Committee on Cancer stage, surgery status, and radiotherapy status were risk factors for both OS and CSS. The C‐index, area under the time‐dependent receiver operating characteristic curve, and calibration plots demonstrated the good performance of the nomograms. DCAs of both nomograms further showed that they exhibited good 3‐, 5‐, and 8‐year net benefits. Conclusions We have developed and validated LSCC prognosis nomograms for OS and CSS for the first time. These nomograms can be valuable tools for clinical practice when clinicians are helping patients to understand their survival risk for the next 3, 5, and 8 years.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nomograms for predicting long‐term overall survival and cancer‐specific survival in lip squamous cell carcinoma: A population‐based study

Pan

Yang

et al. 2019

Cancer Medicine

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“…For radiotherapy, electron beam therapy and brachytherapy are used because the radiation field is limited and located superficially . In 326 lip SCC patients, lymph node metastasis was found in 26 (8%), suggesting that the frequency of cervical lymph node involvement is relatively low. However, when surgical specimens were examined, cervical lymph node metastasis was observed in 18.4% of patients who received neck dissection; the rate was 11.2% in those with N0 .…”

Section: Current Treatment Of Oral Cancermentioning

confidence: 99%

Current treatment, particle radiotherapy, and boron neutron capture therapy for advanced oral cancer in patients

Yura

Tada

Fujita

et al. 2019

Oral Science International

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Malignant tumors such as squamous cell carcinoma (SCC), malignant salivary gland tumor, mucosal melanoma, sarcoma, and lymphoma occur in the oral cavity. Among them, oral SCC accounts for 90%. The frequency of lymph node metastasis of oral SCC varies depending on the site of occurrence, which affects the prognosis. Surgery is the primary treatment for oral cancer, but when the tumor extends, postoperative radiation with or without chemotherapy is required. Photons including X-rays and γ-rays are the most widely used types of ionizing radiation in cancer radiotherapy. Particle radiotherapy using protons and carbon ions shows a highly focused dose distribution to tumor tissues. Carbon ion therapy is effective for salivary gland tumors, malignant melanomas, and sarcomas which are less susceptible to photons. Furthermore, boron neutron capture therapy with tumor selectivity is expected to further reduce damage to surrounding normal cells. The introduction of novel radiotherapy to current treatment might improve the prognosis of patients and organ preservation. K E Y W O R D S chemotherapy, oral cancer, particle radiotherapy, radiotherapy, surgery How to cite this article: Yura Y, Tada S, Fujita Y, Hamada M. Current treatment, particle radiotherapy, and boron neutron capture therapy for advanced oral cancer in patients. Oral Sci Int. 2019;16:49-68. https://doi.

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“…Regression analysis revealed tumor extent, tumor infiltration depth, and grading as the most important factors in the correct classification of Lymph Node Metastasis (LNM) in 94.2% of patients. [ 39 ]…”

Section: Recent Studies On Infiltration Depth As Prognostic Factormentioning

confidence: 99%

Tumor infiltration depth as a prognostic parameter for nodal metastasis in oral squamous cell carcinoma

Hegde

Roy

Shetty

et al. 2017

Int J App Basic Med Res

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Oral squamous cell carcinoma (OSCC) has locoregional evolution, with frequent neck involvement. Significant number of studies have been undertaken to assess the parameters for treatment of N0 neck patients with a high likelihood of harboring occult node metastases. Many studies have indicated tumor infiltration depth (or tumor thickness) as one of the most important criteria in determining the further management. Growing evidence in the literature shows that tumor infiltration depth is a reliable parameter for predicting regional node involvement and patient survival in OSCC. The substantial agreement among authors, despite the lack of comparable study groups, of measurement techniques, and cutoff values paradoxically enforced its reliability. Further studies are clearly awaited to reach a consensus on these topics to develop therapy protocols that are also based on this parameter. This article is an attempt to substantiate the use of tumor infiltration depth as a prognostic factor for nodal metastasis in OSCC.

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Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer

Cited by 41 publications

References 46 publications

Nomograms for predicting long‐term overall survival and cancer‐specific survival in lip squamous cell carcinoma: A population‐based study

Nomograms for predicting long‐term overall survival and cancer‐specific survival in lip squamous cell carcinoma: A population‐based study

Current treatment, particle radiotherapy, and boron neutron capture therapy for advanced oral cancer in patients

Tumor infiltration depth as a prognostic parameter for nodal metastasis in oral squamous cell carcinoma

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