2019
DOI: 10.1016/j.ijantimicag.2019.06.026
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Prediction models for voriconazole pharmacokinetics based on pharmacogenetics: AN exploratory study in a Spanish population

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Cited by 20 publications
(24 citation statements)
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“…Concerning CYP3A4, the trend towards an increased VRC Cmin for IM patients observed in univariate analyses was confirmed in multivariate model 2, in which significance was reached. This finding is in accordance with those of previous studies that demonstrated the impact of genetic polymorphisms of CYP3A4 on VRC exposure [ 14 , 19 , 20 , 21 ]. Conversely, we did not find any association between the VRC Cmin and CYP3A5 genotype.…”
Section: Discussionsupporting
confidence: 93%
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“…Concerning CYP3A4, the trend towards an increased VRC Cmin for IM patients observed in univariate analyses was confirmed in multivariate model 2, in which significance was reached. This finding is in accordance with those of previous studies that demonstrated the impact of genetic polymorphisms of CYP3A4 on VRC exposure [ 14 , 19 , 20 , 21 ]. Conversely, we did not find any association between the VRC Cmin and CYP3A5 genotype.…”
Section: Discussionsupporting
confidence: 93%
“…Conversely, we did not find any association between the VRC Cmin and CYP3A5 genotype. This result is consistent with those of two previous studies performed in healthy European volunteers [ 14 , 39 ] but not in agreement with a Chinese study that highlighted a trend towards a higher frequency of the CYP3A5*1/*3 genotype for patients with a low VRC Cmin [ 21 ]. These discrepancies may be related to different frequencies of the CYP3A5 genotype depending on the study population.…”
Section: Discussionsupporting
confidence: 89%
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“…Since VRC exposure is influenced by genetic polymorphisms of both CYP2C19 [9][10][11]15,17,25 and CYP3A, [17][18][19][20]26 we had previously proposed a genetic score combining the genotypes of both these CYP. 21 While this approach has the advantage of taking into account phenotypes of both main CYPs involved in VRC metabolism, 16 this study showed that the genetic score was not associated with initial VRC C min .…”
Section: Discussionmentioning
confidence: 99%
“…16 Indeed, several studies have shown that genetic polymorphisms of CYP3A4 affect VRC exposure, independently of CYP2C19 genotype. [17][18][19][20] In this context, we previously proposed a combined genetic score integrating the most frequent genetic variants affecting both CYP2C19 and CYP3A, based on a retrospective cohort of 29 allogeneic haematopoietic cell transplant patients, to individualize VRC dosing. 18,21 The relevance of such a combined genetic score was evaluated in a prospective observational study conducted in adult patients with haematological malignancies.…”
Section: Introductionmentioning
confidence: 99%