Prediction of 90-day Mortality After Radical Cystectomy for Bladder Cancer in a Prospective European Multicenter Cohort

Aziz, Atiqullah; May, Matthias; Burger, Maximilian; Palisaar, Rein-Jüri; Trinh, Quoc‐Dien; Fritsche, Hans‐Martin; Rink, Michael; Chun, Felix K.-H.; Martini, Thomas; Bolenz, Christian; Mayr, Roman; Pycha, Armin; Nuhn, Philipp; Stief, Christian G.; Novotný, Vladimír; Wirth, Manfred P.; Seitz, C.; Noldus, Joachim; Gilfrich, Christian; Shariat, Shahrokh F.; Brookman‐May, Sabine; Bastian, Patrick J.; Denzinger, Stefan; Gierth, Michael; Roghmann, Florian

doi:10.1016/j.eururo.2013.12.018

Cited by 174 publications

(107 citation statements)

References 27 publications

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“…These outcomes have been reported extensively for ORC, including reports using standardized Martin criteria. In general, ORC is associated with a high risk of complications (>60%), including a considerable risk of high-grade complications (13-40% in large series) and mortality (up to 7% in some series) [101][102][103][104][105]. ORC outcomes appear to be associated with hospital and surgeon experience and volumes, with several studies demonstrating improved performance in high-volume centers by high-volume surgeons [106,107].…”

Section: Discussionmentioning

confidence: 99%

Systematic Review and Cumulative Analysis of Perioperative Outcomes and Complications After Robot-assisted Radical Cystectomy

et al. 2015

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Context: Although open radical cystectomy (ORC) is still the standard approach, laparoscopic radical cystectomy (LRC) and robot-assisted radical cystectomy (RARC) have gained popularity.Objective: To report a systematic literature review and cumulative analysis of perioperative outcomes and complications of RARC in comparison with ORC and LRC.Evidence acquisition: Medline, Scopus, and Web of Science databases were searched using a free-text protocol including the terms robot-assisted radical cystectomy or da Vinci radical cystectomy or robot* radical cystectomy. RARC case series and studies comparing RARC with either ORC or LRC were collected. Cumulative analysis was conducted.

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Section: Discussionmentioning

confidence: 99%

Systematic Review and Cumulative Analysis of Perioperative Outcomes and Complications After Robot-assisted Radical Cystectomy

et al. 2015

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“…As a treatment for muscle invasive bladder cancer, radical cystectomy remains a highly morbid operation with complication rates of 40-60% and mortality rates as high as 9% in the first 90 days after surgery. [19,20] Albisinni et al [21] have analyzed postoperative complications after laparoscopic radical cystectomy (LRC) and evaluated its risk factors in a large prospective cohort built by the ESUT across European centers involved in minimally invasive urology in the last decade. A total of 548 patients were available for final analysis, of which 258(47%) experienced early complications during the first 90 days after LRC.…”

Section: Resultsmentioning

confidence: 99%

The Immediate Results of Surgical Treatment of Bladder Cancer

Чарышкин¹,

Matorkin²,

Демин³

2016

Int J Biomed

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The objective of this study was to evaluate the immediate results of the use of ureterointestinal anastomosis according to the Bricker technique at radical cystectomy (RC) for bladder cancer (BC). Materials and Results:The study included 96 patients (11.5% women and 88.5% men) with BC, aged from 31 to 74 years (mean age 63.8±7.2), who underwent RC in the Lipetsk Regional Oncology Center, in the period from 2005 to 2014.Among the early postoperative complications, we identified dynamic ileus (16.7%), inflammatory complications of the surgical wound (12.5%), acute pyelonephritis (10.4%), and failure of ureterointestinal anastomosis (4.2%). The frequency of postoperative acute pyelonephritis corresponded to the findings of other authors. Two (2.1%) patients died from early postoperative complications because of concomitant diseases (ischemic heart disease, myocardial infarction); thus, postoperative mortality in the early postoperative period was 4.2%. Chronic pyelonephritis with chronic renal failure detected in 15(15.6%) patients after one year after surgery was the most frequent late postoperative complication. The stricture of ureterointestinal anastomosis in 9(9.4%) patients has been eliminated through relaparotomy and resection of anastomosis. The development of urolithiasis in 12(12.5%) patients after one year after surgery has required the implementation of contact lithotripsy and litholytic therapy. (Int J Biomed. 2016;6(2):110-113.).

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“…Previous short-term mortality studies in RC patients are numerous and identify rates from 2.4 to 8.4% [7][8][9]. Unfortunately these rates are oftentimes assessed at different time-points after PC (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…However, the potential disadvantage of RC consists of its non-negligible perioperative mortality, which may range from 2.4 to 7.9% at centers [7,8] of excellence and from 5.4 to 8.4% in the community [9][10][11]. Perioperative mortality appears lower for PC, evidenced by 1.8% in-hospital mortality after this procedure [12].…”

Section: Introductionmentioning

confidence: 99%

Peri-operative mortality and long-term survival after partial versus radical cystectomy for muscle invasive bladder cancer

Larcher

Sun

Schiffmann

et al. 2015

Bladder

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OBJECTIVE:The aim of the study was to compare partial cystectomy (PC) and radical cystectomy (RC) with respect to 90-day mortality as well as long-term, all cause (ACM) and cancer specific mortality (CSM). METHODS:Using the SEER-Medicare database 3913 patients with T2-T3 urothelial carcinoma of the urinary bladder (UCUB) who underwent either RC (n = 3419) or PC (n = 494) were identified. After propensity score matching to reduce potential treatment selection bias, 90-day mortality, ACM-free and CSM-free rates between patients treated with PC and RC were estimated. Multivariable regression models (MVA) addressed 90-day mortality as well as 5-years ACM and CSM. RESULTS:After matching, 33% (n = 494) and 67% (n = 988) patients treated respectively with PC or RC remained. Median follow-up was 26 months. The 90-day mortality rate was 3.2% (n = 16) after PC and 8.1% (n = 80) after RC (P = 0.001). In MVA, PC vs. RC was associated with a lower 90-day mortality (P < 0.001). At 5 years the ACM-free survival rate was 38% after PC and 40% after RC (P = 0.3) and failed to differ in MVA (P = 0.9). At 5 years the CSM-free survival rate was 59% after PC and 62% after RC (P = 0.2) and also failed to differ in MVA (P = 0.57). The same results were observed after restriction to patients with pT2N0 UCUB. CONCLUSIONS:Relative to RC, PC is associated with lower short-term mortality and the same long-term ACM and CSM rates. These observations should encourage greater consideration to PC in those selected cases when this type of surgery may be applied.

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Prediction of 90-day Mortality After Radical Cystectomy for Bladder Cancer in a Prospective European Multicenter Cohort

Cited by 174 publications

References 27 publications

Systematic Review and Cumulative Analysis of Perioperative Outcomes and Complications After Robot-assisted Radical Cystectomy

Systematic Review and Cumulative Analysis of Perioperative Outcomes and Complications After Robot-assisted Radical Cystectomy

The Immediate Results of Surgical Treatment of Bladder Cancer

Peri-operative mortality and long-term survival after partial versus radical cystectomy for muscle invasive bladder cancer

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