Prediction of Airway Inflammation in Patients with Asymptomatic Asthma by Using Lung Sound Analysis

Shimoda, Terufumi; Nagasaka, Yukio; Obase, Yasushi; Kishikawa, Reiko; Iwanaga, Tomoaki

doi:10.1016/j.jaip.2014.06.017

Cited by 12 publications

(16 citation statements)

References 20 publications

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“…Lung sound data from the healthy volunteers presented in this article were previously published11 and did not include immunoglobulin E data. However, these factors may not have had an impact on these results, as previous data from our laboratory suggested that sex and age do not affect the E/I LF or E/I MF values7,8 and the primary outcomes of this study were evidently clarified by the asthmatic subject data.…”

Section: Discussionmentioning

confidence: 55%

“…We have previously used an analysis of single-point recordings in the lung base to show that E/I MF is best suited for evaluating airway inflammation in bronchial asthma 7,8. In this analysis with multiple-point recordings, we demonstrate that the E/I values in the frequency bands of 100–200 Hz and 200–400 Hz ( E/I LF and E/I MF, respectively) were strongly correlated with airway narrowing, hyperresponsiveness, and inflammation when the lung sounds were recorded at the anterior chest and posterior upper and lower points.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously reported that in asthma patients who are in an attack-free period and exhibit normal sounds based on conventional stethoscope auscultation, airway inflammation can be detected by LSA at a single point in the posterior lower lung field 7,8…”

Section: Introductionmentioning

confidence: 99%

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Lung sound analysis helps localize airway inflammation in patients with bronchial asthma

Shimoda

Obase

Nagasaka

et al. 2017

JAA

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PurposeAirway inflammation can be detected by lung sound analysis (LSA) at a single point in the posterior lower lung field. We performed LSA at 7 points to examine whether the technique could identify the location of airway inflammation in patients with asthma.Patients and methodsBreath sounds were recorded at 7 points on the body surface of 22 asthmatic subjects. Inspiration sound pressure level (ISPL), expiration sound pressure level (ESPL), and the expiration-to-inspiration sound pressure ratio (E/I) were calculated in 6 frequency bands. The data were analyzed for potential correlation with spirometry, airway hyperresponsiveness (PC20), and fractional exhaled nitric oxide (FeNO).ResultsThe E/I data in the frequency range of 100–400 Hz (E/I low frequency [LF], E/I mid frequency [MF]) were better correlated with the spirometry, PC20, and FeNO values than were the ISPL or ESPL data. The left anterior chest and left posterior lower recording positions were associated with the best correlations (forced expiratory volume in 1 second/forced vital capacity: r=−0.55 and r=−0.58; logPC20: r=−0.46 and r=−0.45; and FeNO: r=0.42 and r=0.46, respectively). The majority of asthmatic subjects with FeNO ≥70 ppb exhibited high E/I MF levels in all lung fields (excluding the trachea) and V50%pred <80%, suggesting inflammation throughout the airway. Asthmatic subjects with FeNO <70 ppb showed high or low E/I MF levels depending on the recording position, indicating uneven airway inflammation.ConclusionE/I LF and E/I MF are more useful LSA parameters for evaluating airway inflammation in bronchial asthma; 7-point lung sound recordings could be used to identify sites of local airway inflammation.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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Lung sound analysis helps localize airway inflammation in patients with bronchial asthma

Shimoda

Obase

Nagasaka

et al. 2017

JAA

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“…Flow-volume curves were generated, FeNO and airway hyperresponsiveness to acetylcholine were measured, and sputum was induced and processed in accordance with previously reported procedures [7,8,10,11].…”

Section: Other Examinationsmentioning

confidence: 99%

“…We previously performed a study of nonsmoking corticosteroid-naive patients in the interictal period of bronchial asthma and reported that the exhalation-to-inhalation sound pressure ratio in the low frequency (LF) range (100-200 Hz) (E/I LF), a parameter detected using LSA, was strongly correlated with airway inflammation [7]. Furthermore, we used new software capable of removing noise (EasyLSA) to analyze bronchial asthma patients before therapy and confirmed that the exhalation-to-inhalation sound pressure ratio in the middle frequency (MF) range (200-400 Hz) (E/I MF) was more strongly correlated with airway inflammation, obstruction, and hyperresponsiveness than E/I LF [8].…”

Section: Introductionmentioning

confidence: 99%

Lung Sound Analysis Is Useful for Monitoring Therapy in Patients With Bronchial Asthma

Shimoda¹,

Obase²,

Nagasaka³

et al. 2017

J Investig Allergol Clin Immunol

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Background: Lung sound analysis (LSA) has been reported to be useful for predicting airway obstruction and inflammation in patients with bronchial asthma. Objectives: We examined whether the exhalation-to-inhalation sound pressure ratio in the middle frequency range (200-400 Hz) (E/I MF) is useful for monitoring therapy in patients with asthma. Methods: The study population comprised 84 patients with mild to moderate asthma whose LSA data were available before and after 1 year of daily treatment with (budesonide 800 μg). We analyzed whether the E/I MF before and after treatment was associated with the fractional exhaled nitric oxide (FeNO) level, sputum eosinophil percentage, respiratory function, and airway hyperresponsiveness. Results: Prior to treatment with budesonide, the E/I MF was significantly correlated with respiratory function, airway hyperresponsiveness, FeNO, and sputum eosinophil percentage. The cutoff values for the E/I MF to detect the abnormalities of respiratory function, FeNO, and sputum eosinophil percentage were 0.367, 0.358, and 0.363, respectively. With respect to the reference value, the E/I MF improved significantly in patients whose respiratory function and FeNO benefited from therapy with budesonide compared with patients whose respiratory function did not benefit from budesonide (odds ratios of 6.39 and 4.78, respectively). According to the multivariate analysis, patients whose E/I MF did not improve had a longer history of smoking (P=.038), poorer posttreatment respiratory function (P=.028), and higher posttreatment FeNO (P=.0095). Conclusion: Similar to respiratory function and FeNO, E/I MF based on LSA is a useful indicator for monitoring the efficacy of therapy in asthmatic patients.

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Lung sound analysis can be an index of the control of bronchial asthma

Shimoda

Obase

Nagasaka

et al. 2017

Allergology International

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Prediction of Airway Inflammation in Patients with Asymptomatic Asthma by Using Lung Sound Analysis

Cited by 12 publications

References 20 publications

Lung sound analysis helps localize airway inflammation in patients with bronchial asthma

Lung sound analysis helps localize airway inflammation in patients with bronchial asthma

Lung Sound Analysis Is Useful for Monitoring Therapy in Patients With Bronchial Asthma

Lung sound analysis can be an index of the control of bronchial asthma

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