Prediction of anticancer activities of cynaroside and quercetin in leaf of plants <i>Cynara scolymus</i> L and <i>Artocarpus incisa</i> L using structure–activity relationship

Thuý, Bùi Thị Phương; Nhung, Nguyen Thi Ai; Duong, Tran Bach; Trung, Phùng Văn; Quang, Nguyen Minh; Dung, Hoang Thi Kim; Tất, Phạm Văn

doi:10.1080/23312009.2016.1212452

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…Investigating the apoptosis-induction, nano-TP/Flowers exhibited apoptosis in PC-3 with a higher ratio than in A549 cells through flow cytometry and gene expression assays. Our results agreed with their reported anticancer activities [ 25 , 61 ], either through apoptosis-induction or antioxidant activation. A previous study [ 26 ] synthesized AgNPs via Cynara scolymus leaf extracts and showed their anticancer activity through apoptosis-induction.…”

Section: Discussionsupporting

confidence: 93%

“…Polyphenolic compounds exhibited a crucial impact in the treatment of cancer [ 24 ]. So, previous studies reported the cytotoxic effect of C. scolymus L. against different types of cancer such as cervical (HeLa) [ 25 ], breast (MCF-7) [ 26 ], liver (HepG-2) [ 27 ], and colon (HCT-116) cancer cell lines [ 28 ]. Prostate cancer is the fifth key reason of death around the world and the second most common tumor (after lung tumor) in men as well [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Silver Nanoparticles Formulation of Flower Head’s Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation

et al. 2022

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Cynara scolymus L. (Family: Compositae) or artichoke is a nutritious edible plant widely used for its hepatoprotective effect. Crude extracts of flower, bract, and stem were prepared and evaluated for their in vitro antioxidant activity and phenolic content. The flower crude extract exhibited the highest phenolic content (74.29 mg GAE/gm) as well as the best in vitro antioxidant activity using total antioxidant capacity (TAC), ferric reducing antioxidant power (FEAP), and 1,1-diphenyl-2-picrylhyazyl (DPPH) scavenging assays compared with ascorbic acid. Phenolic fractions of the crude extracts of different parts were separated and identified using high-performance liquid chromatography HPLC-DAD analysis. The silver nanoparticles of these phenolic fractions were established and tested for their cytotoxicity and apoptotic activity. Results showed that silver nanoparticles of a polyphenolic fraction of flower extract (Nano-TP/Flowers) exhibited potent cytotoxicity against prostate (PC-3) and lung (A549) cancer cell lines with IC50 values of 0.85 μg/mL and 0.94 μg/mL, respectively, compared with doxorubicin as a standard. For apoptosis-induction, Nano-TP/Flowers exhibited apoptosis in PC-3 with a higher ratio than in A549 cells. It induced total prostate apoptotic cell death by 227-fold change while it induced apoptosis in A549 cells by 15.6-fold change. Nano-TP/Flowers upregulated both pro-apoptotic markers and downregulated the antiapoptotic genes using RT-PCR. Hence, this extract may serve as a promising source for anti-prostate cancer candidates.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Formulation of Flower Head’s Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation

et al. 2022

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“…Des études antérieures ont montré que la quercétine 9 pourrait avoir des activités antioxydantes, antiinflammatoires, immunomodulatrices, anticancéreuses et gastro-protectrices (Li et al, 2008;Thuy et al, 2016). L'effet anti-hyperglycémiant de l'extrait éthanol des feuilles de Spondias purpurea L. observé dans cette étude sur un test de tolérance au glucose, pourrait être lié à la présence de flavonoïdes.…”

Section: Essais Sur Un Test De Tolérance Au Glucoseunclassified

Activité Anti-Hyperglycémiante Et Élucidation Structurale Des Composés Isolés Des Feuilles De Spondias Purpurea L. (Anacardiaceae)

Diatta

Manga

Gassama

et al. 2017

ESJ

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Spondias purpurea L. (Anacardiaceae) is a Senegalese traditional pharmacopoeia plant, which leaves are used in the treatment of various diseases. The leaves’ ethanolic extract exhibited antihyperglycemic activity on models of temporary hyperglycemia. The tests were performed on normoglycemic rats with a glucose tolerance test. The phytochemical investigation of the leaves resulted in the isolation of four flavonoids (quercetin 9, kaempferol 10, quercetin-3- ß-glucopyranoside 6, kaempferol3-ß-galactopyranoside 8), five phenolic compounds (2,4-dihydroxybenzoic acid 2, 4-hydroxybenzoic acid 5, protocatechic 4-ß-glucoside acid 1, hydroxycynnamic acid 7, 5-caffeoylquinic acid 3) and one tannin (Strictinin 4). The known isolated compounds were characterized by NMR and massspectrometry. The present study constitutes the first phytochemical examination of the leaves and the anti-hyperglycemic activity of the ethanolic extract of Spondias Purpurea L.

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“…i. Chemicals and equipment: In this work, we used the chemicals and the equipments for isolating and purifying two flavonoids luteolin and daidzin before determining the substance structures by 1H-NMR and 13C-NMR spectrum [25].…”

Section: Eisolation Of Luteolin and Daidzin From Plantmentioning

confidence: 99%

“…To isolate and purify the luteolin and daidzin compound from the leaves of Perilla ocymoides L and Glucine max L we used the techniques of thin-layer and column chromatography [25], as exhibited in (Figures 3-4). After isolating the compounds their structures were identified by the different spectrum as…”

Section: F Isolation Process Of Luteolin and Daidzinmentioning

confidence: 99%

In silico Modelling of 2D, 3D Molecular Descriptors for Prediction Of Anticancer Activities Of Luteolin And Daidzin From Plants Perilla ocymoides L and Glucine max L

Tất¹

2017

OMCIJ

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Recently, we have isolated two flavonoids luteolin and daidzin from leaves of Perilla ocymoides L and Glucine max L in Viet Nam [1], with cytotoxic activity relatively strong in Hela cell line. To clarify the important nature of the relationships between structure and activity, the QSAR studies on Hela cell line incorporated the principal component analysis (PCA) technique and the artificial neural network (ANN) to construct the QSAR PCA-ANN relationships. The best multiple linear model QSAR MLR (with k = 6) values R 2 train of 0.854 and R 2 pred of 0.812, and QSARPCR (with k = 6) values R 2 train of 0.937 and R 2 pred of 0.889 were found by using the multiple linear regression technique. The artificial neural network QSAR PCA-ANN with architectural style I (6)-HL (9)-O (1) represented the values R 2 train of 0.993 and R 2 pred of 0.971. In the case the incorporated model QSAR PCA-ANN with the architecture I (6)-HL (9)-O (1) was exhibited the higher training and predicted quality. The anticancer activities of test substances resulting from those models are in good agreement with those from literature. The anti-cancer activities of two compounds luteolin and daidzin from leaves of Perilla ocymoides L and Glucine max L resulting from those models turn out to be agreement with experimental data.

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Prediction of anticancer activities of cynaroside and quercetin in leaf of plants Cynara scolymus L and Artocarpus incisa L using structure–activity relationship

Cited by 8 publications

References 15 publications

Silver Nanoparticles Formulation of Flower Head’s Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation

Silver Nanoparticles Formulation of Flower Head’s Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation

Activité Anti-Hyperglycémiante Et Élucidation Structurale Des Composés Isolés Des Feuilles De Spondias Purpurea L. (Anacardiaceae)

In silico Modelling of 2D, 3D Molecular Descriptors for Prediction Of Anticancer Activities Of Luteolin And Daidzin From Plants Perilla ocymoides L and Glucine max L

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