Prediction of Aphasia Outcome Using Diffusion Tensor Tractography for Arcuate Fasciculus in Stroke

Kim, S.H.; Jang, Sung Ho

doi:10.3174/ajnr.a3259

Cited by 81 publications

(86 citation statements)

References 43 publications

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“…19 All these patterns of tumors cause DTI parameter changes, in particular FA decrease, in involved regions. 20 Furthermore, the presence of voxels with FA values lower than the DTI threshold (commonly set to 0.2) causes an interruption of reconstructed WM tracts, 21 and the use of an FA threshold lower than 0.2 results in poor accuracy of major eigenvector-direction estimation. 1 These limitations can produce 3 negative effects on tractographic presurgical planning, particularly in CST evaluation.…”

Section: Discussionmentioning

confidence: 99%

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MRI Tractography of Corticospinal Tract and Arcuate Fasciculus in High-Grade Gliomas Performed by Constrained Spherical Deconvolution: Qualitative and Quantitative Analysis

Mormina

Longo

Arrigo

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: MR imaging tractography is increasingly used to perform noninvasive presurgical planning for brain gliomas. Recently, constrained spherical deconvolution tractography was shown to overcome several limitations of commonly used DTI tractography. The purpose of our study was to evaluate WM tract alterations of both the corticospinal tract and arcuate fasciculus in patients with high-grade gliomas, through qualitative and quantitative analysis of probabilistic constrained spherical deconvolution tractography, to perform reliable presurgical planning.

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Section: Discussionmentioning

confidence: 99%

“…21,22 This WM bundle connects to Broca, Wernicke, and Geschwind areas and other brain regions involved in language and speech. 23 Because brain stimulation techniques are less effective for WM tracts than for GM, evaluating the morphologic localization of the AF is essential for appropriate presurgical planning.…”

Section: Discussionmentioning

confidence: 99%

MRI Tractography of Corticospinal Tract and Arcuate Fasciculus in High-Grade Gliomas Performed by Constrained Spherical Deconvolution: Qualitative and Quantitative Analysis

Mormina

Longo

Arrigo

et al. 2015

AJNR Am J Neuroradiol

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“…18,22) The present findings further suggest the diagnostic applicability of DTI for aphasia. 30,[34][35][36] Previous DTI studies in normal subjects reported that fiber connection is greater in the left arcuate fasciculus than in the right, 5,37) implying left brain dominance for language function in humans. To reevaluate this issue, we set ROIs (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…23) Previous DTI studies of aphasia caused by stroke reported that FA decreased in the left arcuate fasciculus and adjacent white matter fibers. 5,[27][28][29][30][31][32] In accordance with these previous findings, we set ROIs to include the arcuate fasciculus as defined in the skeletonized FA images (shown in Fig. 1).…”

Section: Image Processingmentioning

confidence: 99%

Reduced Diffusion Tensor Fractional Anisotropy in the Left Arcuate Fasciculus of Patients with Aphasia Caused by Acute Cerebral Infarct

Koyama

Domen

2016

PRM

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INTRODUCTIONAphasia is a common symptom in the acute stage following cerebral infarct. 1) Recent neuroimaging studies have revealed many aspects of the neuropathology of aphasia. 2,3) Aphasia is often associated with lesions within language-related cortical regions such as Wernicke's and Broca's areas or within the neural fiber networks connecting these regions. 4,5) However, the contributions of specific tracts remain unclear, in part because white matter tract disruption cannot be detected by classical neuroimaging modalities. In contrast to classical neuroimaging techniques, magnetic resonance diffusion tensor imaging (DTI) enables the assessment of neural fiber integrity in vivo. 6) Consequently, DTI may be a useful tool for identifying the subcortical white matter structures responsible for aphasia.Most recent DTI studies of aphasia caused by cerebral infarct have investigated patients in the chronic stage. [7][8][9][10] However, patients with aphasia show various patterns of recovery during the months and years after stroke, 11,12) partially resulting from compensation and/or neural plasticity among language-related and other brain areas. 13-15) Accordingly, DTI studies of patients in the chronic phase may not be sufficient to fully describe the neuropathology of aphasia. In this study, we examined patients with aphasia caused by cerebral infarct in the acute stage by using DTI. 16) To determine the Background: Magnetic resonance diffusion tensor imaging (DTI) is a new technique that evaluates neural fiber integrity within the brain. We conducted DTI in patients exhibiting aphasia during the acute stage post-infarct and investigated the neural tracts responsible by comparison with DTI data from age-matched controls. Methods: Fractional anisotropy (FA) maps were generated from diffusion tensor brain images obtained from aphasic patients 14−21 days following their first infarct. Tract-based spatial statistics (TBSS) analysis was then applied. In addition, regions of interest (ROIs) were set within the right and left arcuate fasciculus, and mean FA values were extracted from individual TBSS data. The ratios between FA values in the left and right hemispheres were compared with those of the control group. Results: The study examined 10 aphasic patients and 21 age-matched controls. Brain maps from TBSS analysis revealed significantly reduced FA in the left arcuate fasciculus of the patient group compared with that in the control group. Copyright © 2016 The Japanese Association of Rehabilitation Medicine lesions responsible, we applied tract-based spatial statistics (TBSS) 17) in reference to age-matched control subjects.

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“…Lower FA values in the superior longitudinal and arcuate fasciculi of the left hemisphere were correlated with decreased ability to repeat spoken language, and lower FA values in the arcuate fasciculus were associated with comprehension deficits; these relationships were independent of the degree of damage to cortical areas [60]. The outcome of aphasia was improved in patients whose left FA could be reconstructed [61]. …”

Section: Structural Imagingmentioning

confidence: 99%

Contribution of Neuro-Imaging for Prediction of Functional Recovery after Ischemic Stroke

Heiss¹

2017

Cerebrovasc Dis

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Prediction measures of recovery and outcome after stroke perform with only modest levels of accuracy if based only on clinical data. Prediction scores can be improved by including morphologic imaging data, where size, location, and development of the ischemic lesion is best documented by magnetic resonance imaging. In addition to the primary lesion, the involvement of fiber tracts contributes to prognosis, and consequently the use of diffusion tensor imaging (DTI) to assess primary and secondary pathways improves the prediction of outcome and of therapeutic effects. The recovery of ischemic tissue and the progression of damage are dependent on the quality of blood supply. Therefore, the status of the supplying arteries and of the collateral flow is not only crucial for determining eligibility for acute interventions, but also has an impact on the potential to integrate areas surrounding the lesion that are not typically part of a functional network into the recovery process. The changes in these functional networks after a localized lesion are assessed by functional imaging methods, which additionally show altered pathways and activated secondary centers related to residual functions and demonstrate changes in activation patterns within these networks with improved performance. These strategies in some instances record activation in secondary centers of a network, for example, also in homolog contralateral areas, which might be inhibitory to the recovery of primary centers. Such findings might have therapeutic consequences, for example, image-guided inhibitory stimulation of these areas. In the future, a combination of morphological imaging including DTI of fiber tracts and activation studies during specific tasks might yield the best information on residual function, reserve capacity, and prospects for recovery after ischemic stroke.

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Prediction of Aphasia Outcome Using Diffusion Tensor Tractography for Arcuate Fasciculus in Stroke

Abstract: BACKGROUND AND PURPOSE:The AF is an important neural tract in language function. We investigated aphasia outcome according to DTT findings for AF in the early stage of stroke.

Cited by 81 publications

References 43 publications

MRI Tractography of Corticospinal Tract and Arcuate Fasciculus in High-Grade Gliomas Performed by Constrained Spherical Deconvolution: Qualitative and Quantitative Analysis

MRI Tractography of Corticospinal Tract and Arcuate Fasciculus in High-Grade Gliomas Performed by Constrained Spherical Deconvolution: Qualitative and Quantitative Analysis

Reduced Diffusion Tensor Fractional Anisotropy in the Left Arcuate Fasciculus of Patients with Aphasia Caused by Acute Cerebral Infarct

Contribution of Neuro-Imaging for Prediction of Functional Recovery after Ischemic Stroke

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