Prediction of Atopic Asthma in Children with Asthma in Early Life

Abstract

Background: Childhood asthma is the most frequent chronic non-communicable condition. Preschool and early childhood wheeze is common for many children. Asthma can be a lifelong problem for some children. Atopic asthma is the commonest based on gene-environment interactions identified by international research over the past 20 years.Objective: This study aimed to predict atopic bronchial asthma in children at risk. Methods: The present cross-sectional study was carried out on 50 asthmatic patients (29 males and 21 females). Apparently normal 20 children of comparable age, sex and socioeconomic status were taken as a control group. The patients were recruited from Otorhinolaryngology Clinics. They were suspected of atopic asthma with allergic rhinitis or repeated attacks of common cold or other risk factors. The study was conducted through the period from May 2021 to December 2021. Results: Asthma was more prevalent in males in 2 groups with significant difference. There were significant differences between asthmatic groups regarding family history of atopic diseases, seasonal variations, serum IgE titer but non-significant regarding parasitic infestations, chest X-ray abnormalities and studied variables. There was significant positive correlation between serum IgE titer and attacks severity, history of atopy and eosinophilia but not with seasonal and diurnal variation. Conclusion: The presence of atopic diseases, family history of atopic diseases, high serum eosinophilic count and high serum IgE titer in children with asthma in early life was found to be predictive to the development of persistent asthma in adulthood.