Prediction of atopy via total immunoglobulin E levels andskin prick tests in patients with psoriasis

Khoshkhui

et al. 2019

pdia

Introduction The relationship between allergic and autoimmune diseases is an important issue, which has recently attracted the researchers’ interest. Aim To determine the relationship between atopy and psoriasis. Material and methods This case-control study was conducted on 102 patients referred to the Ghaem Hospital, Mashhad, Iran, in 2016. The participants were assigned into two groups: experimental and control groups, including the patients suffering from psoriasis and those with no history of cutaneous or other systemic diseases, respectively. Both groups filled in the ISAAC questionnaire and had skin prick tests. In addition, the serum levels of immunoglobulin E (IgE) and blood eosinophil cell count were measured. The data were analysed using the regression test through SPSS version 16. Results According to the results of the ISAAC questionnaire, there was a significant difference between the control and experimental groups in terms of asthma ( p = 0.04). The mean serum concentrations of IgE and eosinophil cell count were not significantly different between the experimental (153.93 IU/ml and 187.77 cells/μl, respectively) and control groups (152.19 IU/ml and 187.68 cells/μl, respectively) ( p = 0.057 and p = 0.886, respectively). In addition, there was an indirect correlation between the eosinophil cell count and psoriasis severity ( p = 0.032, r = –0.297). Furthermore, the comparison of the skin prick test results revealed no significant difference between the two groups regarding the number of positive and negative cases ( p = 0.436). Conclusions The findings suggested that atopy was not common in the patients with psoriasis and supported the concept that atopy protects against such autoimmune diseases such as psoriasis.

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Investigation of the relationship between atopy and psoriasis

Khoshkhui

et al. 2019

pdia

“…There are limited number of studies in the literature investigating the predisposition to atopy in psoriasis and showing contradictory results 7,8 . In the present study, total serum Ig E and radioallergosorbent test (RAST) (Allergen-specific IgE Antibody test) were used in psoriasis patients in order to investigate this correlation.…”

Section: Introductionmentioning

confidence: 99%

Variations of Total-Aeroallergen Specific IgE and Eosinophil Levels in Psoriasis

Güner¹

2020

jamp

The aim of the present study was to investigate the predisposition to atopy in psoriasis vulgaris. Total serum immunoglobulin E (Ig E) and radioallergosorbent test (RAST) (Allergen-specific IgE Antibody test) were used in psoriasis patients in order to investigate this correlation. Forty-eight psoriasis patients and thirty-nine healthy control group were included in the study. Allergen-specific IgE antibody test for peripheral eosinophilia, serum total Ig E and Dermatophagoides (D.) pteronyssinus and D. farinae was applied to all the study group. The treatment, severity of the disease, age, gender, and the duration of the disease were taken into account in the patient group, no statistically significant difference was detected in terms of allergen-specific IgE antibody test for D. pteronyssinus and D. farinae (p>0.05). Serum IgE and eosinophil were seen at a higher rate in psoriasis patients (p < 0.05). Patients with psoriasis have elevated levels of serum eosinophil and serum total Ig E. Although there is no aeroallergen specific immune shift associated in relation to house dust mites, serum IgE and eosinophils may be important important in the course and follow-up of the disease.

“…First, it offers convenience as the preparation of blood tests only involves a standard blood draw. 15,16 Second, the blood test is regarded as safer because the process is conducted in vitro, and thus does not expose patients to allergens. 17,18 Third, the blood tests can serve as an alternative to skin tests for patients who suffer from severe symptoms and cannot interrupt medication.…”

Section: Introductionmentioning

confidence: 99%

A selective and sensitive nanosensor for fluorescent detection of specific IgEs to purified allergens in human serum

Yun

Duan

et al. 2018

RSC Adv.

Food allergies are increasingly recognized as a major healthcare concern. In order to sensitively and specifically detect allergies from blood samples of at-risk allergic patients, an effective magnetic fluorescence sensing platform (EMFP) was constructed. The EMFP incorporated hollow mesoporous silica nanospheres (HMNs) to amplify signal from the target IgE in addition to magnetic nanoparticles (MNPs) to capture and separate the target IgE. The application of EMFP to immunoassays indicated a detection limit of 0.0159 ng mL À1 for low concentration specific immunoglobulin E (sIgE) against purified shellfish Metapenaeus ensis (Meta. E.) allergens, which is 15 fold more sensitive than the commercially available Food and Drug Administration-approved analyzers. Notably, EMFP was specific for the targeted sIgE even with interference by other sIgEs. In addition, the detection time is only 75 min, considerably faster than current commercial ELISA kits for IgE assays. Together, these results demonstrated that EMFP has excellent sensitivity and selectivity for the rapid detection of sIgE. The method thus exhibits potential toward the rapid monitoring of sIgE against Meta. E. allergens in clinical application.