In the parallel separation process of two bodies, the initial velocity state and the surrounding flow field environment jointly determine the motion state of the two bodies, which is a direct determinant of the separation process safety. To study the two-body parallel separation process and the influencing factors, this paper adopts the dynamic mesh technique and finite volume method to solve the Navier-Stokes equations and study the influence of the initial separation clearance and velocity state on the separation process. The results show that: with the increase of the initial separation clearance, the separation process safety of two bodies under the action of complex flow field may decrease; the effect is poor when the two bodies are separated at rest, and a suitable initial velocity state is beneficial to improve the separation safety to achieve the purpose of safe separation, and the two bodies show different separation processes under different initial velocity states.