Prediction of Cannabis Use Disorder between Boyhood and Young Adulthood: Clarifying the Phenotype and Environtype

Kirisci, Levent; Tarter, Ralph E.; Mezzich, Ada C.; Ridenour, Ty; Reynolds, Maureen; Vanyukov, Michael

doi:10.1080/10550490802408829

Cited by 54 publications

(96 citation statements)

References 33 publications

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“…It is especially important to identify these difficulties early, as early initiation increases the likelihood for the development of a problematic life trajectory (Clark & Winters, 2002;Crone & Dahl, 2012;Kirisci et al, 2009).…”

Section: Individual Differences In Decision-making Competencementioning

confidence: 99%

Preadolescent Decision‐Making Competence Predicts Interpersonal Strengths and Difficulties: A 2‐Year Prospective Study

Weller

Moholy

Bossard

et al. 2014

Behavioral Decision Making

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Recent research has demonstrated that decision-making competence (DMC), a latent construct reflecting individual differences in rational thought, is predictive of real-world decision outcomes at various stages of life. This construct has been shown to be associated with concurrent and retrospective accounts of health-risking behavior, but its predictive validity has yet to be demonstrated. In the present study, we examine this issue using a 2-year prospective, multiple-informant design. Specifically, we tested the degree to which preadolescent DMC (PA-DMC) obtained at ages 10-11 years (Time 1; N = 101) predicted both self-reports and caregiver reports of emotional, behavioral, and peer-related difficulties obtained 2 years later (Time 2; N = 76). Holding variables such as numeracy and inhibitory control constant, lower Time 1 PA-DMC scores predicted greater reported Time 2 psychosocial difficulties (i.e. peer, conduct, emotional, and hyperactivity/inattention problems). Additionally, higher PA-DMC scores were associated with greater self-reported prosocial behaviors at Time 2. These results highlight the utility of testing individual differences in rational responding. We discuss the potential for improving children's decision-making processes.

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Section: Individual Differences In Decision-making Competencementioning

confidence: 99%

Preadolescent Decision‐Making Competence Predicts Interpersonal Strengths and Difficulties: A 2‐Year Prospective Study

Weller

Moholy

Bossard

et al. 2014

Behavioral Decision Making

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“…Variation in liability to drug use initiation can be explained by shared and non-shared environment [45,46] , in contrast to liability to SUD where the genetic component of variance is predominant [47,48] . The co-existence of both GT and CLM in our model, which only explores initiation sequences, is thus not surprising.…”

Section: Common Liability To Addictionsmentioning

confidence: 99%

The Gateway Hypothesis, Common Liability to Addictions or the Route of Administration Model? A Modelling Process Linking the Three Theories

Mayet¹,

Legleye

Beck

et al. 2015

Eur Addict Res

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Background: The aim of this study was to describe the transitions between tobacco (T), cannabis (C) and other illicit drugs (OIDs) initiations, to simultaneously explore several substance use theories: gateway theory (GT), common liability model (CLM) and route of administration model (RAM). Methods: Data from 2 French nationwide surveys conducted in 2005 and 2010 were used (16,421 subjects aged 18-34). Using reported ages at initiations, we reconstituted a retrospective cohort describing all initiation sequences between T, C and OID. Transition probabilities between the substances were computed using a Markov multi-state model that also tested the effect of 2 latent variables (item response theory scores reflecting propensity for early onset and further substance use) on all transitions. Results: T initiation was associated with increased likelihood of subsequent C initiation, but the reverse relationship was also observed. While the most likely initiation sequence among subjects who initiated the 3 groups of substances was the ‘gateway' sequence T → C → OID, this pattern was not associated with substance use propensity more than alternative sequences. Early use propensity was associated with the ‘gateway' sequence but also with some alternative ones beginning with T, C or OID. Conclusion: If the gateway sequence appears as the most likely pattern, in line with GT, the effects of early onset and substance use propensities were also observed for some alternative sequences, which is more in line with CLM. RAM could explain reciprocal interactions observed between T and C. This suggests shared influences of individual (personality traits) and environmental (substance availability, peer influence) characteristics.

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“…The TLI has documented construct, discriminative and predictive validity (Kirisci et al, 2009; Vanyukov et al, 2009). Sons of SUD+ fathers score on average approximately 0.5 SD higher on the TLI than sons of SUD− fathers (Vanyukov et al, 2009).…”

Section: Methodsmentioning

confidence: 99%

Temperament disturbances measured in infancy progress to substance use disorder 20years later

Horner

Reynolds

Braxter

et al. 2015

Personality and Individual Differences

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Objective This prospective study determined whether temperament before two years of age predicts transmissible risk for substance use disorder (SUD) up to a decade later and SUD outcome in adulthood. Method Boys between 10 and 12 years of age (N = 482) were tracked to age 22. The previously validated transmissible liability index (TLI) was administered at baseline, and temperament prior to two years of age was retrospectively rated. The Structured Clinical Interview for DSM-III-R (SCID) was administered to document presence/absence of SUD for parents at baseline and sons at age 22. Results Path analysis revealed that number of parents with SUD predicted severity of temperament disturbance in their sons which in turn predicted TLI score at age 10–12, presaging SUD. Temperament before age two did not predict SUD at age 22. The association between number of SUD parents and transmissible risk was mediated by severity of temperament disturbance. Conclusion Temperament disturbance in early childhood, reflecting quality of behavioral and emotion regulation, comprise psychological antecedents of transmissible risk for SUD.

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Prediction of Cannabis Use Disorder between Boyhood and Young Adulthood: Clarifying the Phenotype and Environtype

Cited by 54 publications

References 33 publications

Preadolescent Decision‐Making Competence Predicts Interpersonal Strengths and Difficulties: A 2‐Year Prospective Study

Preadolescent Decision‐Making Competence Predicts Interpersonal Strengths and Difficulties: A 2‐Year Prospective Study

The Gateway Hypothesis, Common Liability to Addictions or the Route of Administration Model? A Modelling Process Linking the Three Theories

Temperament disturbances measured in infancy progress to substance use disorder 20years later

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