Prediction of cardiac events following concurrent chemoradiation therapy for non-small-cell lung cancer using FDG PET

Cho, Sang-Geon; Kim, Yong-Hyub; Park, Hyukjin; Park, Ki Seong; Kim, Jahae; Ahn, Sung‐Ja; Bom, Hee‐Seung

doi:10.1007/s12149-022-01724-w

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…Cho et al. found intense visual LV uptake in 46% of patients, moderate uptake in 34%, and mild uptake in 20%, with focal uptake observed in 7% of patients ( 38 ). Sha et al.…”

Section: Resultsmentioning

confidence: 99%

“…The median age ranged from 45.3 to 62.2 years. The primary cancers included thoracic malignancies ( 34 ), esophageal cancer ( 32 , 35 , 39 , 40 ), lung cancer ( 33 , 37 , 38 ), and BC ( 36 ). The KPS was reported in two studies, with median values of 80% ( 39 ) and 90% ( 37 ).…”

Section: Resultsmentioning

confidence: 99%

“…Four studies used IMRT ( 37 – 40 ), one study evaluated stereotactic body radiation therapy (SBRT) for lung cancer ( 33 ), and seven studies used 3DCRT ( 32 , 34 – 36 , 38 , 40 ). Prescribed doses varied, ranging from 50.4 to 66.0 Gy for esophageal cancer, 50.4 Gy in 28 fractions with a boost dose of 10–16 Gy in 5–8 fractions for breast cancer, and a median dose of 64 Gy (30–76 Gy) for thoracic malignancies ( 34 ).…”

Section: Resultsmentioning

confidence: 99%

“…In this review, two studies found that changes in cardiac SUV before and after treatment were predictive of overall survival ( 37 , 39 ). While some studies found no predictive value of FDG uptake changes after RT ( 32 ), others observed a significant association with cardiac events, particularly in patients with higher MHD ( 38 ). However, the short follow-up periods and potential confounding factors, such as preexisting cardiac risk and combined treatment effects, need to be considered ( 64 ).…”

Section: Discussionmentioning

confidence: 98%

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Nuclear medicine imaging methods of early radiation-induced cardiotoxicity: a ten-year systematic review

Eber,

Blondet,

Le Fevre

et al. 2023

Front. Oncol.

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IntroductionRadiotherapy has significantly improved cancer survival rates, but it also comes with certain unavoidable complications. Breast and thoracic irradiation, for instance, can unintentionally expose the heart to radiation, leading to damage at the cellular level within the myocardial structures. Detecting and monitoring radiation-induced heart disease early on is crucial, and several radionuclide imaging techniques have shown promise in this regard. MethodIn this 10-year review, we aimed to identify nuclear medicine imaging modalities that can effectively detect early cardiotoxicity following radiation therapy. Through a systematic search on PubMed, we selected nineteen relevant studies based on predefined criteria. ResultsThe data suggest that incidental irradiation of the heart during breast or thoracic radiotherapy can cause early metabolic and perfusion changes. Nuclear imaging plays a prominent role in detecting these subclinical effects, which could potentially serve as predictors of late cardiac complications.DiscussionHowever, further studies with larger populations, longer follow-up periods, and specific heart dosimetric data are needed to better understand the relationship between early detection of cardiac abnormalities and radiation-induced heart disease.

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“…Cho et al. found intense visual LV uptake in 46% of patients, moderate uptake in 34%, and mild uptake in 20%, with focal uptake observed in 7% of patients ( 38 ). Sha et al.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Nuclear medicine imaging methods of early radiation-induced cardiotoxicity: a ten-year systematic review

Eber,

Blondet,

Le Fevre

et al. 2023

Front. Oncol.

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“…In patients treated with doxorubicin, an increased LV 18 F-FDG uptake from baseline to end-of-treatment PET is associated with a subsequent LVEF drop 85 and MACE. 201 Moreover, increased RV 18 F-FDG uptake predicts a higher cardiotoxicity risk. 202 Similarly, in chest radiotherapy patients, focal cardiac 18 F-FDG uptake is associated with myocardial damage, 203 – 205 a study pointing towards a relation between the radiotherapy dose and the intensity of 18 F-FDG uptake.…”

Section: Early Signs Of Cardiac Dysfunctionmentioning

confidence: 99%

Tales from the future—nuclear cardio-oncology, from prediction to diagnosis and monitoring

Mikaïl

Chequer

Impériale

et al. 2023

European Heart Journal - Cardiovascular Imaging

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Cancer and cardiovascular disease often share common risk factors, and patients with cardiovascular disease who develop cancer are at high risk of experiencing major adverse cardiac events. Additionally, cancer treatment can induce short- and long-term adverse cardiovascular events. Given the improvement in oncological patients’ prognosis, the burden in this vulnerable population is slowly shifting towards increased cardiovascular mortality. Consequently, the field of cardio-oncology is steadily expanding, prompting the need for new markers to stratify and monitor the cardiovascular risk in oncological patients before, during, and after the completion of treatment. Advanced noninvasive cardiac imaging has raised great interest in the early detection of cardiovascular diseases and cardiotoxicity in oncological patients. Nuclear medicine has long been a pivotal exam to robustly assess and monitor the cardiac function of patients undergoing potentially cardiotoxic chemotherapies. In addition, recent radiotracers have shown great interest in the early detection of cancer treatment-related cardiotoxicity. In this review, we summarize the current and emerging nuclear cardiology tools that can help identify cardiotoxicity and assess the cardiovascular risk in patients undergoing cancer treatments, and discuss the specific role of nuclear cardiology alongside other noninvasive imaging techniques.

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Predictive Value of Changes in Basal Myocardial 18F-Fluorodeoxyglucose Uptake for Cardiotoxicity in Patients With Locally Advanced Esophageal Cancer Receiving Definitive Radiation Therapy

Cai,

Wang,

Zhao

et al. 2024

International Journal of Radiation Oncology*Biology*Physics

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Prediction of cardiac events following concurrent chemoradiation therapy for non-small-cell lung cancer using FDG PET

Cited by 9 publications

References 31 publications

Nuclear medicine imaging methods of early radiation-induced cardiotoxicity: a ten-year systematic review

Nuclear medicine imaging methods of early radiation-induced cardiotoxicity: a ten-year systematic review

Tales from the future—nuclear cardio-oncology, from prediction to diagnosis and monitoring

Predictive Value of Changes in Basal Myocardial 18F-Fluorodeoxyglucose Uptake for Cardiotoxicity in Patients With Locally Advanced Esophageal Cancer Receiving Definitive Radiation Therapy

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