Prediction of Cardiovascular Events and All-Cause Mortality With Erectile Dysfunction: A Systematic Review and Meta-Analysis of Cohort Studies

Vlachopoulos, Charalambos; Terentes‐Printzios, Dimitrios; Ioakeimidis, Nikolaos; Aznaouridis, Konstantinos; Rokkas, K.; Synodinos, A.; Christoforatou, Evangelia; Aggelis, Athanasios; Samentzas, A.; Stefanadis, Christodoulos

doi:10.1016/s0735-1097(12)62075-0

Cited by 94 publications

(166 citation statements)

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“…Factors underlying this connection remain unknown, 13 but both conditions have been associated with increased age, 2,14-16 comorbid disorders (eg, diabetes, 2,8,16 cardiovascular events, 17,18 radical prostatectomy 19,20 ), psychological symptoms, [9][10][11]15,21,22 and altered blood flow. 13 In addition, ED has been associated with depression, 22 which, similar to PD, may influence a patient's assessment of physical and psychological functioning.…”

mentioning

confidence: 99%

Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease

Şerefoğlu

Smith²,

Kaufman³

et al. 2017

Urology

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OBJECTIVETo elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie disease (PD). METHODSA post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in 2 phase 3 trials of collagenase clostridium histolyticum ( RESULTSPain during intercourse (P = .02) and PD bother (P <.0001) had a significant impact on International Index of Erectile Function, erectile function scores. The Peyronie's Disease Questionnaire bother domain score was significantly affected by penile curvature deformity, penile shortening, pain during intercourse, and the presence of plaques (P ≤.0005 for all), with pain during intercourse having the greatest impact (maximum likelihood estimation ± standard error = .496 ± .030; P <.0001). Erectile function did not appear to be directly influenced by the presence of plaques, penile curvature deformity, or penile shortening but was associated with PD bother and penile pain. CONCLUSIONThis post hoc analysis provides a conceptual framework through which disease characteristics may impact PD-related bother and erectile function in patients with PD. UROLOGY 107: 155-160, 2017. © 2017 The Author(s). Published by Elsevier Inc. P eyronie disease (PD) is a penile condition that is characterized by focal fibrosis of the tunica albuginea that results in the formation of plaque(s), curvature or deformation of the penis, and, in some cases, pain. 1 The prevalence of PD ranges from 3.2% to 11.8% of men, depending on the definition of PD used and the population studied. [2][3][4] The underlying cause of PD is unknown but likely involves abnormal wound healing. 5 This abnormal response facilitates collagen deposition, changes in collagen fiber content, and plaque formation. [5][6][7] Most patients with PD present between the ages of 52 and 57 years. 2,8 Although pain typically resolves over time, 1 penile curvature or deformity persists and may impact patients' psychological health, relationships with their sexual partners, and emotional well-being. 9,10 For example, a singlecenter, cross-sectional study demonstrated that more than half of patients with PD experienced relationship problems because of the condition, and 81% reported emotional problems. 9 Furthermore, an observational study of 92 men with PD demonstrated that almost half (48%) indicated that they were depressed and that the depression had not resolved over time. 11 Interestingly, in that study, depression was significantly associated with patients' perception of penile shortening, 11 suggesting that depression may

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mentioning

confidence: 99%

Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease

Şerefoğlu

Smith²,

Kaufman³

et al. 2017

Urology

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“…27 The authors concluded that the risk posed by ED on future cardiovascular events is of a similar magnitude to more established risk factors such as hypertension, diabetes or dyslipidaemia. The Princeton Consensus panel recommend that sexual function is incorporated into cardiovascular risk assessment for all men, and discuss extensively the management of cardiovascular risk in the ED patient.…”

Section: Erectile Dysfunctionmentioning

confidence: 98%

Metabolic syndrome and common urological conditions: looking beyond the obvious

Rees

Kirby

2014

Trends Urol & Men's Health

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“…Not surprisingly, ED shares the common cardiovascular risk factors [6] as outlined in Table I. Of interest, ED frequently precedes coronary and peripheral artery disease by two to fi ve years (mean three years) [5,6]. Nevertheless, there is a remaining gap in evidence on routine screening for ED in men.…”

Section: Arterial Imaging and Endovascular Therapy Of Arteriogenic Edmentioning

confidence: 99%

“…Therefore, it is not surprising that ED shares the common cardiovascular risk factors. Furthermore, ED is often associated with other chronic diseases i. e. coronary artery disease [4][5][6][7] or obstructive sleep apnoea syndrome [8,9]. Montorsi et al reported a 70 % prevalence of ED in a consecutive series of 300 patients presenting with acute chest pain and angiographically documented coronary artery disease [4].…”

Section: Introductionmentioning

confidence: 99%

Erectile dysfunction – overview from a cardiovascular perspective

Baumann¹,

Hehli

Makaloski

et al. 2017

Vasa

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Summary:Erectile dysfunction (ED) is an evolving health problem with growing incidence in the ageing male population with potentially predictive value for cardiovascular and other chronic diseases. ED shares the common cardiovascular risk factors. The aetiology of ED is numerous including neurogenic, psychogenic, arteriogenic, and venogenic reasons. The origin of arteriogenic ED is frequently atherosclerosis. Patients not adequately responding to conservative measures including oral medication are often referred to further vascular diagnostics and therapy. At present, the refi nements in endovascular therapy allow for minimal-invasive revascularization of erection-related arteries. The role of endovascular therapy in the complex framework of the multifactorial causes of ED requires further scientifi c scrutiny.

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Prediction of Cardiovascular Events and All-Cause Mortality With Erectile Dysfunction: A Systematic Review and Meta-Analysis of Cohort Studies

Cited by 94 publications

References 0 publications

Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease

Factors Associated With Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients With Peyronie Disease

Metabolic syndrome and common urological conditions: looking beyond the obvious

Erectile dysfunction – overview from a cardiovascular perspective

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