Prediction of carotid intima–media thickness in obese patients with low prevalence of comorbidities by serum copper bioavailability

Abstract

Our data show that an altered copper bioavailability predicts early atherosclerosis as main CV risk in obese patients with hepatic steatosis detected by ultrasound, shedding some light in this pathological scenario.

Whole-grain consumption and its effects on hepatic steatosis and liver enzymes in patients with non-alcoholic fatty liver disease: a randomised controlled clinical trial

“…It is assumed in our study that the reduction in oxidative stress and inflammatory markers due to the consumption of whole grains has been responsible for the decrease in liver enzymes and steatosis; nonetheless, further investigations are needed. On the other hand, whole-grain foods are a good source of micronutrients such as Cu, which is identified as a key player in various metabolic disorders (31) . Reduced serum and hepatic Cu concentrations characterise NAFLD patients and seem to have an important role in the progression of metabolic diseases.…”

Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack

“…Trace metals including iron, zinc and copper are essential for many cellular functions and for optimal adaptive and innate immune responses (151). Among these three metals, iron and copper exert an important influence on the genesis of NAFLD (152)(153)(154)(155). Adults, but not children, with NAFLD manifest increased circulating concentrations of ferritin; however, both age groups exhibit increased transferrin saturation (153,154).…”

Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway

“…Secondly, it was reported that copper may play a key role in NAFLD pathogenesis. A tight link between copper homeostasis and lipid metabolism has been well recognized (Feldman et al, 2015;Tarantino et al, 2018). Resent study found that adipocyte-specific Atp7a, a P-type ATPase that transports copper across cell membranes, knockout mice present hepatic steatosis and upregulated peroxisome proliferator activated receptor g (PPARg) in gonadal white adipose tissue (Tao et al, 2019).…”