Univariate analysis on the permeability-reducing effects of cement infiltration into sandy soil was carried out using a series of experiments on sandy soil infiltrated by adding fine cement grains. The SPSS statistical analysis software was used on these experimental data to construct multivariate prediction models on the permeability-reducing effects of cement infiltration into sandy soils. The results indicate that it is possible to predict permeability-reducing effects using transfer functions. Relatively satisfactory predictions were achieved by inputting the postponed time of water supply, soil dry density, quantity of added cement, water pressure head of cement infiltration, physical clay-silt particle content of soil, and other factors as independent variables. A comparison between the multivariate linear and non-linear models showed that the two models had similar accuracy. The multivariate linear model is relatively simple, and hence can be used to predict permeability-reducing effects. The development of the models has scientific implications for soil modification by altering soil permeability through cement infiltration. It also has practical significance in predictive research on reducing the migration of ground surface pollutants into groundwater.