Prediction of Clinical and Mucosal Severity of Coeliac Disease and Dermatitis Herpetiformis by Quantification of IgA/IgG Serum Antibodies to Tissue Transglutaminase

Dahlbom, Ingrid; Korponay-Szabó, Ilma Rita; Kovács, Judit B.; Szalai, Zsuzsanna; Mäki, Markku; Hansson, Tomas

doi:10.1097/mpg.0b013e3181a81384

Cited by 140 publications

(126 citation statements)

References 32 publications

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“…[6,20] Furthermore, correlations between anti-TG levels and histopathologic features of CD have been repeatedly described in children with high titers of anti-TG, directly correlating with villous atrophy. [29,30,31,32] A strong association of CD with HLA-DQ2 and HLA-DQ8 was also found, with a diagnostic sensitivity of >96%. Consequently, a negative HLA-DQ2 and/or HLA-DQ8 result makes the diagnosis of CD highly unlikely [33].…”

Section: Diagnosismentioning

confidence: 86%

Celiac Disease in Children: What Has Changed?

Nevoral

2016

IJCD

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The perception of celiac disease (CD) has changed dramatically during the last two decades, with the introduction of new serological tests with high specificity and sensitivity. CD prevalence in recent years is increasing as it is for other autoimmune diseases. Due to the high prevalence of CD, it is one of the most important diseases of the digestive tract. The clinical manifestations of CD have changed significantly in the last two decades, and these are much more diverse than reported previously. The new European Society for Pediatric Gastroenterology, Hepatology, and Nutrition diagnostic criteria for CD indicate that biopsy can be avoided in strictly selected groups of pediatric patients. The first experiences with these new criteria are positive. A meta-analysis evaluating the relationship between early nutrition and the risk of CD recommends that both early (< 4 months) and late (> 7 months) introduction of gluten to the diet should be avoided, and that gluten should be introduced while the infant is still breastfeeding. The prevalence rates of CD between two cohorts with different infant feeding practice were significantly different, and the prevalence of CD in 12-year-old children were significantly reduced, suggesting that prevention of CD is possible.

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Section: Diagnosismentioning

confidence: 86%

Celiac Disease in Children: What Has Changed?

Nevoral

2016

IJCD

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“…The vast majority of DH patients do not have any abdominal complaint, even when more than 75-90 % of all cases present histological changes in their small bowel mucosa similar to those in CD patients: partial or total villous atrophy and lymphocytic infiltration of the bowel's mucous membrane (2,22).…”

Section: Discussionmentioning

confidence: 99%

Does dermatitis herpetiformis result in bone loss as coeliac disease does?: a cross sectional study

Lőrinczy

Juhász

Csontos

et al. 2013

Rev. esp. enferm. dig.

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Introduction and objectives: coeliac disease (CD) and its cutaneous manifestation, dermatitis herpetiformis are both (DH) glutensensitive diseases. Metabolic bone disease is common among patients with CD, even in asymptomatic forms. Data are scarce about bone density in patients with dermatitis herpetiformis. The aim of our study was to compare bone mineral density (BMD) of celiac and dermatitis herpetiformis patients.Methods: 34 coeliac patients, 53 with dermatitis herpetiformis and 42 healthy controls were studied. The mean age was 38.0 ± 12.1, 32.18 ± 14.95, 35.33 ± 10.41 years in CD, dermatitis herpetiformis, and healthy controls, respectively. Bone mineral density of the lumbar spine, the left femoral neck and radius were measured by dual-energy X-ray absorptiometry. Low bone density, osteopenia and osteoporosis were defined as a body mass density (BMD) T-score between 0 and -1, between -1 and -2.5, and under -2.5, respectively.Results: at lumbar region, consisting of dominantly trabecular compartment, a decreased BMD was detected in 49 % (n = 26) patients with dermatitis herpetiformis, 62 % (n = 21) of CD patients, and 29 % (n = 12) of healthy controls, respectively. Lower BMD were measured at the lumbar region in dermatitis herpetiformis and CD compared to healthy subjects (0.993 ± 0.136 g/cm 2 and 0.880 ± 0.155 g/cm 2 vs. 1.056 ± 0.126 g/cm 2 ; p < 0.01). Density of bones consisting of dominantly cortical compartment (femoral neck) did not differ in dermatitis herpetiformis and healthy subjects.Conclusions: our results show that a low bone mass is also frequent among patients with dermatitis herpetiformis. Bone mineral content in these patients is significantly lower in those parts of the skeleton which contain more trabecular than cortical bone.

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“…It has been elegantly demonstrated that tTGA levels correlate with the degree of small bowel lesions, expressed as a Marsh score, 24 and symptomatic patients with CD and tTGA levels .10 times the upper limit of normal have a high likelihood of being affected by the disease. [24][25][26] Moreover, scores on gastrointestinal symptoms correlate with tTGA levels in adult patients, 26 and young children with severe signs of malabsorption have significantly higher tTGA levels than older children presenting with nonspecific symptoms.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Celiac Disease: A Prospective Birth Cohort

2015

PEDIATRICS

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To investigate clinical features of celiac disease (CD) and their association with risk factors for CD in a genetic risk birth cohort.METHODS: Children from 6 clinical centers in 4 countries positive for HLA-DR3-DQ2 or DR4-DQ8 were annually screened for tissue transglutaminase antibodies (tTGA) and assessed for symptoms by questionnaires. Associations of symptoms with anthropometrics, known risk factors for CD, tTGA levels, and mucosal lesions in those biopsied were examined.RESULTS: Of 6706 screened children, 914 developed persistent positive tTGA, 406 underwent biopsies, and 340 had CD. Compared with age-matched tTGA-negative children, those with persistent tTGA were more likely to have symptoms at 2 (34% vs 19%, P , .001) and 3 years of age (28% vs 19%, P = .009) but not at 4 years (27% vs 21%, NS). Z-scores for height, weight, and BMI did not differ between groups. In children with persistent tTGA, having $1 symptom was associated with family history of CD (odds ratio = 2.59, 95% confidence interval, 1.21-5.57) but not with age, gender, or HLA-DR3-DQ2 homozygosity. At seroconversion, tTGA levels were higher in symptomatic than asymptomatic children (P , .001), in those from CD families (P , .001), and in US participants (P , .001) but not associated with age, gender, or HLA genotype. tTGA levels correlated with severity of mucosal lesions both in symptomatic (r = 0.53, P , .001) and asymptomatic children (r = 0.22, P = .01).

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Prediction of Clinical and Mucosal Severity of Coeliac Disease and Dermatitis Herpetiformis by Quantification of IgA/IgG Serum Antibodies to Tissue Transglutaminase

Cited by 140 publications

References 32 publications

Celiac Disease in Children: What Has Changed?

Celiac Disease in Children: What Has Changed?

Does dermatitis herpetiformis result in bone loss as coeliac disease does?: a cross sectional study

Clinical Features of Celiac Disease: A Prospective Birth Cohort

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