Prediction of clinical outcomes in Crohn’s disease by using confocal laser endomicroscopy: results from a prospective multicenter study

Advanced endoscopic imaging for diagnosis of inflammatory bowel diseases: Present and future perspectives

“…29 Most recently, our group has shown that focal cryptitis and crypt architectural abnormalities are frequently observed in Crohn's patients. 30 These patients showed an increased incidence of medical treatment escalation and transmural lesions at 1-year follow up. Confocal imaging showed specific features of mucosal inflammation and allowed for early prediction of relevant clinical outcome parameters.…”

“…Most recently, our group has shown that focal cryptitis and crypt architectural abnormalities are frequently observed in Crohn's patients . These patients showed an increased incidence of medical treatment escalation and transmural lesions at 1‐year follow up.…”

Intravital Imaging Techniques for Biomedical and Clinical Research

“…Beyond the esophagus, pCLE has been used for accurate detection of other diseases such as gastric carcinoma, helicobacter pylorus infection, celiac disease, and inflammatory bowel diseases (IBD) such as colitis and Crohn's disease . In IBD, pCLE has been shown to improve clinical outcome during surveillance of patients by detecting colitis and Crohn's disease‐related mucosal inflammation . pCLE has also been demonstrated to markedly improve identification of mucosal alterations in ulcerative colitis where a 4.75‐fold higher neoplasia detection rate (over conventional colonoscopy) has been attained through the use of methylene blue staining of the tissue (chromoendoscopy) .…”

Optical biopsy in gastroenterology: Focus on confocal laser endomicroscopy

“…In the GI tract, CLE has been evaluated for the following indications: identification of dysplasia in Barrett's esophagus [6], classification of gastric and colorectal polyps ( Table 1), assessment of disease activity and development of dysplasia in inflammatory bowel disease [18,19], evaluation of indeterminate biliary strictures [20], and characterization of solid and cystic pancreatic masses [21,22]. In addition, limited data suggests that CLE may be potentially useful for the in vivo identification of celiac disease (villous atrophy and increased intraepithelial lymphocytes) [23], ampullary lesions [24], and follow up after endoscopic mucosal resection (EMR) of colorectal polyps [25].…”