Prediction of contrast‐induced acute kidney injury by early post‐procedural analysis of urinary biomarkers and intra‐renal Doppler flow indices in patients undergoing coronary angiography

Wybraniec, Maciej T.; Chudek, Jerzy; Bożentowicz-Wikarek, Maria; Mizia-Stec, Katarzyna

doi:10.1111/joic.12404

Cited by 27 publications

(13 citation statements)

References 30 publications

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“…In our study, SEN, SPE, and AUC were used for indicating the performance of uKIM-1 for CI-AKI prediction; all the studies showed that uKIM-1 was a good predictor. e AUC values were above 0.70 for all studies (in fact, two studies reported an AUC >0.90 (18,22)). Moreover, the pooled AUC (0.88, 95% CI 0.85-0.90) also indicates a considerable value in using uKIM-1 for the diagnosis of CI-AKI.…”

Section: Discussionmentioning

confidence: 78%

“…All studies were single-center trials that had their findings published between 2013 and 2017. Of the included studies, 7 were published in English [ 8 – 10 , 17 – 19 , 22 ], and 2 were published in Chinese [ 20 , 21 ]. The 9 studies included a total of 946 adult patients from 5 countries who underwent PCI or GAC, and 144 were diagnosed as CI-AKI.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, one article [17] was found during the manual review of the references of a review article [1] and included in this meta-analysis. In summary, 9 original studies [8][9][10][17][18][19][20][21][22] were included in this metaanalysis.…”

Section: Study Selectionmentioning

confidence: 99%

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The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis

Huang

Shi

et al. 2020

Journal of Interventional Cardiology

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Background. Urinary kidney injury molecule 1 (uKIM-1) is a proximal tubular injury biomarker for predicting acute kidney injury (AKI); its prognostic value varies depending on the clinical and population characteristics. However, the predictive value of uKIM-1 for diagnosis of contrast-induced acute kidney injury (CI-AKI) remains unclear. Method. Medline, Embase, ClinicalTrials.gov, Cochrane Library database, and the China National Knowledge Infrastructure (CNKI) were used to identify relevant studies from their inception to November 31, 2019. Studies that met the inclusion criteria were included. Relevant data were extracted to obtain pooled sensitivity (SEN) and specificity (SPE), summary receiver operating characteristic curve (ROC), and area under the ROC (AUC or AUROC). A bivariate mixed-effects regression model was used for data analysis. Results. A total of 946 patients from 8 eligible studies were included. Across all the studies, the diagnostic odds ratio (DOR) for uKIM-1 level to predict CI-AKI was 19 (95% CI 10–39), with SEN and SPE of 0.84 and 0.78, respectively. The AUROC for uKIM-1 in predicting CI-AKI was 0.88 (95% CI 0.85–0.90). There was a substantial heterogeneity across the studies (I2 was 37.73% for the summary sensitivity and 69.31% for the summary specificity). Conclusion. Urinary KIM-1 has a high predictive value for diagnosis of CI-AKI in patients who have undergone cardiac catheterization.

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Section: Discussionmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

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The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis

Huang

Shi

et al. 2020

Journal of Interventional Cardiology

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“…This phase has been defined “ subclinical AKI ” (Figure ). In the present issue of the Journal of Interventional Cardiology Wybraniec et al report the advantage of the combined assessment of urinary IL‐18 at 6 h and the renal resistive index at 1 h after CM exposure for the early diagnosis of CI‐AKI after coronary artery procedures . However, it is still unclear (i) whether one biomarker should be preferred to others in the setting of CI‐AKI; (ii) which is the best time‐window between CM exposure and assessment of AKI; and (iii) whether the assessment of these new biomarkers and/or non‐invasive indices might guide the therapeutic approaches and therefore improve the early and long‐term outcome.…”

Section: Ci‐aki Definitionmentioning

confidence: 97%

Editorial: Contrast‐induced acute kidney injury

Briguori

Labalestra

Condorelli

2017

J Interven Cardiology

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“…Many demographic, clinic, laboratory, and imaging method parameters were found related to CIN development. Very recently, pre-and post-CA/PCI procedural renal resistive index (RRI) obtained by renal Doppler ultrasonography (USG) were reported as significantly and independently related to CIN occurrence [3,4]. RRI is the most frequently used and acknowledged renal Doppler USG parameter, but it is affected by many demographic, clinic, and systemic parameters [5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Increased renal cortical stiffness obtained by share-wave elastography imaging significantly predicts the contrast-induced nephropathy in patients with preserved renal function

et al. 2019

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Purpose We aimed to investigate the relation between renal cortical stiffness (CS) obtained by shear-wave elastography (SWE) and contrast-induced nephropathy (CIN) development in interventional treatment-planned acute coronary syndrome (ACS) patients. Methods Our study group consisted of 465 ACS patients. Routine laboratory assessments, B-mode, Doppler, and SWE renal ultrasonography (USG) evaluations were performed. Renal resistive index (RRI), renal pulsatility index (RPI), and acceleration time (AT) and CS were measured. Patients were grouped as with and without CIN. Results Among the study group, 55 patients (11.8%) had CIN. Age, diabetes mellitus (DM), hypertension (HT), basal creatinine, CK-MB and troponin I levels, contrast volume, contrast volume/weight ratio, SYNTAX score, RRI, RPI, AT, and CS values were significantly higher in patients with CIN. eGFR was lower in patients who developed CIN. Age, contrast volume/weight ratio, and CS were determined as independent predictors of CIN occurrence in logistic regression analysis. In multivariate logistic analysis, increase of age (each year), contrast volume/weight (each 0.2 mL/kg), and CS (each 1 kPa) were found to augment the development of CIN by 7.1, 59.5, and 62.3%, respectively. In the ROC analysis, CS had the highest AUROC value. The cutoff value of CS obtained by the ROC curve analysis was 7 kPa for the CIN development (sensitivity: 74.5%, specificity: 72.5%). Conclusion CS value is a simple, cheap, reproducible, noninvasive, and objective parameter for the detection of CIN development. ACS patients should be directed to renal USG, and routine CS value should be written besides USG measurements in reports.

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Prediction of contrast‐induced acute kidney injury by early post‐procedural analysis of urinary biomarkers and intra‐renal Doppler flow indices in patients undergoing coronary angiography

Abstract: Joint assessment of early post-procedural urinary biomarkers and Doppler renovascular parameters aids early diagnosis of CI-AKI in patients undergoing coronary interventions.

Cited by 27 publications

References 30 publications

The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis

The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis

Editorial: Contrast‐induced acute kidney injury

Increased renal cortical stiffness obtained by share-wave elastography imaging significantly predicts the contrast-induced nephropathy in patients with preserved renal function

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