Developmental domains refer to different areas of a child’s growth and maturation, including physical, language, cognitive, and social–emotional skills. Understanding these domains helps parents, caregivers, and professionals track a child’s progress and identify potential areas of concern. Nevertheless, due to the high level of heterogeneity and overlap, neurodevelopmental disorders may go undiagnosed in children for a crucial period. Detecting neurodevelopmental disorders at an early stage is fundamental. Digital tools like artificial intelligence can help clinicians with the early detection process. To achieve this, a new method has been proposed that creates artificial features from the original ones derived from the SmartSpeech project, using a feature construction procedure guided by the Grammatical Evolution technique. The new features from a machine learning model are used to predict neurodevelopmental disorders. Comparative experiments demonstrated that using the feature creation method outperformed other machine learning methods for predicting neurodevelopmental disorders. In many cases, the reduction in the test error reaches up to 65% to the next better one.