Prediction of creatinine clearance from serum creatinine concentration based on lean body mass

Abstract

An equation for predicting endogenous creatinine clearance (CrCl) in adults and children (with both stable and unstable renal function) from serum creatinine concentration is presented. The predictions are compared with four other available estimating methods, bases on values in 110 subjects with renal impairment of widely differing degrees. In patients with stable and with unstable renal function the corelaion between measured and predicted CrCl was better with the new equation. In patients with rapid changing renal function the new equation resulted in accurate predictions CrCl within a few hours after the change, as opposed to several with the other methods. The elimination rate constant of the aminoglycoside antibiotic amikacin correlated more precisely with CrCl values estimated from the new equation that with those measured doing 24 hr or with the other prediction methods.

Prediction of creatinine clearance from plasma creatinine: comparison of five formulae.

“…The formulae of Cockcroft & Gault (1976) is the one most often quoted and has been evaluated by many investigators (Durakovic', 1986;Gates, 1985;Hallynck et al, 1981;Hull et al, 1981;Salazar & Corcoran, 1988;Sawyer et al, 1982). Good correlations between measured GFR and predicted CLcr [from the formula of Cockcroft & Gault (1976)] have been reported (r = 0.858, Durakovic', 1986) (r2 = 0.91, Hallynck et al, 1981.…”

“…For this purpose several formulae have been described to estimate creatinine clearance from plasma creatinine concentration (Beranek & Gabriel, 1985;Cockcroft & Gault, 1976;Gates, 1985;Hull et al, 1981;Jelliffe, 1973;Mawer et al, 1972), and Smith (1988) recommends that clinical laboratories should report calculated creatinine clearance whenever serum creatinine is reported. There have been some attempts to compare the effectiveness of these formulae (Durakovic', 1986;Gates, 1985;Hallynck et al, 1981;Rhodes et al, 1987;Sawyer et al, 1982;Sinton et al, 1986) but very few studies have compared several formulae (Rhodes et al, 1987). In this study we have compared the effectiveness of estimated creatinine clearance using five different formulae in a Chinese population.…”

Impaired renal function in patients with myocardial infarction treated with primary angioplasty and the risk for failed myocardial tissue reperfusion and thus worse long-term outcomes

“…In addition, there was no information about the time from the onset of symptoms to admission [15]. It should be noted here that serum creatinine level measured at admission could be considered as a reliable indicator of renal function if the blood sample is obtained within 5 h from the onset of symptoms of myocardial infarction, which is one of the clinical conditions that can potentially lead to renal hypoperfusion [16]. In our study, in the group of patients with impaired renal function, the median time from the onset of chest pain to admission was 4.4 h. The mean value of eGFR in this group was 41 ±14 ml/min/1.73 m 2 , indicating renal dysfunction in stage 3 of renal failure according to the National Kidney Foundation (NKF), and argues for chronic kidney disease in these patients [11].…”

Do We Need Another Look at Serum Uric Acid in Cardiovascular Disease? Serum Uric Acid as a Predictor of Outcomes in Acute Myocardial Infarction

“…Or, both?. Indeed, AMI per se causes a reduction in renal function (thus potentially reflecting on SUA levels due to a reduced excretion -studies on kinetics of creatinine elimination suggest that changes due to a sudden decline in renal function are to be expected within 5-6 hours (Hallynck et al, 1981, Hillege et al, 2003. Furthermore, as depicted in Figure 3, cardiac ischemia is likely to result in activation of XO.…”